Reproductive aging: biological pathways and potential interventive strategies

Liu, Yuanyuan; Gao, Jinmin

doi:10.1016/j.jgg.2022.07.002

Cited by 10 publications

(12 citation statements)

References 93 publications

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“…The multidirectional activity of SIRT1 contributes to changes in the epigenome and mainly in the DNA acetylome, as well as the oxidative status of the cell, and is one of the keys to understanding oocyte aging processes [ 16 , 51 , 52 ]. A reflection of aging processes is the final sequences of chromosomes, called telomeres.…”

Section: Sirt1 and Agingmentioning

confidence: 99%

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Grzeczka

Kordowitzki

2022

Nutrients

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It is well-known that there is an enormous variability in the aging-related decline of oocytes’ quantity and their developmental competence among mammalian species. The implication of female germline aging is profound from the perspective of evolutionary conservation of the aging mechanism, a topic of continuous and widespread interest that has yet to be fully addressed for the mammalian oocyte. There is a certain need to develop novel antiaging strategies to delay or slow down aging, or even to reverse the aging phenotype in the oocyte. In the past two decades, several antioxidants have been tested for this purpose. Resveratrol is one of these latter-mentioned compounds, which has shown anti-inflammatory and antiaging properties in a dose-dependent manner. Interestingly, resveratrol appears to enhance the activity of so-called Sirtuin 1, too. Therefore, the aim of this review is to summarize and discuss the latest findings related to resveratrol, Sirtuin 1, and their crosstalk and influence on the mammalian oocyte to elucidate the question of whether these factors can delay or slow down reproductive aging.

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Section: Sirt1 and Agingmentioning

confidence: 99%

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Grzeczka

Kordowitzki

2022

Nutrients

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“…Several gamete intrinsic changes occur with advanced reproductive age which underlie decreased egg quality, including an increase in chromosome and mitochondria abnormalities (Beverley et al, 2021; Duncan et al, 2012; Gruhn et al, 2019; Liu & Gao, 2022; Wang et al, 2011). However, oocytes do not develop and function in isolation but rather in a heterogenous ovarian microenvironment composed of granulosa, stromal, immune, and endothelial cells, and extracellular matrix (ECM) components (Fan et al, 2019; Wagner et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan

Babayev,

Suebthawinkul,

Gokyer

et al. 2023

Aging Cell

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Reproductive aging is associated with ovulatory defects. Age‐related ovarian fibrosis partially contributes to this phenotype as short‐term treatment with anti‐fibrotic compounds improves ovulation in reproductively old mice. However, age‐dependent changes that are intrinsic to the follicle may also be relevant. In this study, we used a mouse model to demonstrate that reproductive aging is associated with impaired cumulus expansion which is accompanied by altered morphokinetic behavior of cumulus cells as assessed by time‐lapse microscopy. The extracellular matrix integrity of expanded cumulus–oocyte complexes is compromised with advanced age as evidenced by increased penetration of fluorescent nanoparticles in a particle exclusion assay and larger open spaces on scanning electron microscopy. Reduced hyaluronan (HA) levels, decreased expression of genes encoding HA‐associated proteins (e.g., Ptx3 and Tnfaip6), and increased expression of inflammatory genes and matrix metalloproteinases underlie this loss of matrix integrity. Importantly, HA levels are decreased with age in follicular fluid of women, indicative of conserved reproductive aging mechanisms. These findings provide novel mechanistic insights into how defects in cumulus expansion contribute to age‐related infertility and may serve as a target to extend reproductive longevity.

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“…In humans, successful fertilization depends on the integration of paternal genomes from haploid sperm cells with maternal DNA from the oocyte, ensuring transmission of a properly functioning genome to the next generation. The efficient production of healthy mature spermatozoa through spermatogenesis and spermiogenesis is a continuous and essential process for the fertility of individuals assigned male at birth (AMAB) 3 …”

Section: Introductionmentioning

confidence: 99%

“…The efficient production of healthy mature spermatozoa through spermatogenesis and spermiogenesis is a continuous and essential process for the fertility of individuals assigned male at birth (AMAB). 3 A comprehensive andrological consultation and examination are essential for all AMAB individuals seeking assistance for infertility.…”

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confidence: 99%

Sperm DNA fragmentation testing in clinical management of reproductive medicine

Adler,

Roth,

Lundy

et al. 2023

Reprod Medicine & Biology

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BackgroundApproximately 8%–12% of couples worldwide face infertility, with infertility of individuals assigned male at birth (AMAB) contributing to at least 50% of cases. Conventional semen analysis commonly used to detect sperm abnormalities is insufficient, as 30% of AMAB patients experiencing infertility show normal results in this test. From a genetic perspective, the assessment of sperm DNA fragmentation (SDF) is important as a parameter of sperm quality.MethodsIn this narrative study, we review and discuss pathophysiological causes, DNA repair mechanisms, and management of high SDF. We then summarize literature exploring the association between SDF and reproductive outcomes.Main FindingsRecent systematic reviews and meta‐analyses have revealed a significant association between high SDF in AMAB individuals and adverse reproductive outcomes including embryo development, natural conception, intrauterine insemination, and in vitro fertilization. However, the association with live birth rates and pregnancy rates following intracytoplasmic injection remains inconclusive. The disparities among quantitative assays, inconsistent reference range values, absent high‐quality prospective clinical trials, and clinical heterogeneity in AMAB patients with elevated SDF represent the main limitations affecting SDF testing.ConclusionThe evaluation and management of SDF plays an important role in a subset of AMAB infertility, but widespread integration into clinical guidelines will require future high‐quality clinical trials and assay standardization.

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Reproductive aging: biological pathways and potential interventive strategies

Cited by 10 publications

References 93 publications

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan

Sperm DNA fragmentation testing in clinical management of reproductive medicine

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