Reproducibility of the water drinking test in treated glaucomatous patients

“…Nevertheless, we did find a statistically significant change in IOP recovery following the LPI, when we measured the difference between the maximal and minimal IOPs during the WDT. It is important to note, however, that while the IOP peak observed during the WDT has been shown to be reproducible, fluctuation between the maximal and minimal values of IOP were not reproducible in short‐term and long‐term follow‐up . Therefore, fluctuation may not be the most appropriate method metric for making longitudinal observations.…”

Section: Discussionmentioning

confidence: 99%

Water‐drinking test in primary angle‐closure suspect before and after laser peripheral iridotomy

Waisbourd

Savant

Sun

et al. 2015

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

Background: This study aimed to investigate whether performing a laser peripheral iridotomy in primary angle-closure suspects had an effect on the intraocular pressure response during the water-drinking test.Design: Prospective study in a hospital setting.Participants: Primary angle-closure suspects scheduled for a laser peripheral iridotomy.Methods: Primary angle-closure suspects were evaluated before the laser peripheral iridotomy and 2 weeks after. On each visit, subjects underwent the waterdrinking test. Intraocular pressure was measured every 15 min within a 1-h period.Main Outcome Measures: Intraocular pressure fluctuations during the water drinking test.Results: Twenty patients were enrolled. The mean age was 58.1 years (±10.2 SD), predominantly female (n = 14, 70%). Average intraocular pressure range (maximum-minimum) during the waterdrinking test increased significantly from 2.6 ± 1.1 mmHg before the laser peripheral iridotomy to 3.5 ± 1.5 mmHg after (P = 0.04). The mean difference between peak and last intraocular pressure measurements increased after the laser peripheral iridotomy was performed, from 2.5 mmHg (±1.27 SD) to 3.3 mmHg (±1.66 SD), (P = 0.057). There was no change in mean peak intraocular pressure (maximum-baseline) before and after the laser peripheral iridotomy (P = 0.87).Conclusions: Primary angle-closure suspects who underwent the water-drinking test had a slightly more pronounced recovery of intraocular pressure after the laser peripheral iridotomy was performed, which may be attributed to increase in the area of exposed trabecular meshwork following treatment. Differences in intraocular pressure curves before and after laser peripheral iridotomy were minimal, and therefore, the water-drinking test had limited value as a provocative test in this patient population.

show abstract

“…This is based on the understanding that the magnitude of IOP fluctuations is correlated with glaucomatous damage and progressively worsening visual field loss . More recently, the WDT is also being used to measure ocular outflow facility indirectly and, in doing so, assess glaucoma risk and/or progression …”

Section: Discussionmentioning

confidence: 99%