Reproducibility of the hemodynamic response to auditory oddball stimuli: A six‐week test–retest study

Kiehl, Kent A.; Liddle, Peter F.

doi:10.1002/hbm.10074

Cited by 87 publications

(74 citation statements)

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“…This extensive network of brain regions associated with target detection may be similar to the attention network discussed by Mesalum (Mesulam, 1990;Mesulam, 2000). Others have suggested that processing salient stimuli is associated with an 'reflexive' or 'automatic' orienting process that is reliably activates an extensive neural network despite the low probability that all activated brain regions are required for successful task performance (Kiehl et al, 2001a;Kiehl et al, 2001b;Kiehl & Liddle, 2003;Kiehl et al, 2005).Also consistent with study hypotheses, target detection was associated with greater hemodynamic activity during the single-tone condition compared to the two-tone condition in bilateral middle temporal gyrus, inferior frontal and middle prefrontal gyri. These findings are consistent with electrophysiological and magnetoencephalogram studies of single-, two-and three-tone oddball tasks.…”

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confidence: 72%

“…Hemodynamic activity was examined in a group of participants who performed both a two-stimulus version of the oddball and a version containing only targets (single-stimulus) (Polich et al, 1994;Polich & Heine, 1996;Polich & Margala, 1997). The first aim of this study was to determine whether the brain areas previously activated by target detection during a three-stimulus oddball task (Kiehl et al, 2001a;Kiehl et al, 2001b;Kiehl & Liddle, 2003) also were activated by the different contextual task manipulations. It was hypothesized that target stimuli would elicit hemodynamic activity in the same diverse, spatially distributed neural network implicated in previous depth electrode and three-stimulus fMRI oddball studies.…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

“…ERP source localization studies suggest that the P3 is localized to the bilateral prefrontal cortex, parietal-occipital junction, and parietal lobe, while the N1 is localized predominantly to bilateral auditory cortex, with some evidence supporting additional sources in the prefrontal cortex (Anderer et al, 1998;Giard et al, 1994;Halgren et al, 1995a;Liegeois-Chauvel et al, 1994). Functional magnetic resonance imaging (fMRI) studies have confirmed and extended these findings Casey et al, 2001;Clark et al, 2001;Clark et al, 2000;Kiehl et al, 2001a;Kiehl et al, 2001b;Kiehl & Liddle, 2003;Kiehl et al, 2005;Kirino et al, 2000;Linden et al, 1999;McCarthy et al, 1997;Menon et al, 1997;Opitz et al, 1999;Stevens et al, in press;Strange & Dolan, 2001). These studies report that target detection elicits widespread cortical and subcortical activation, including multiple foci in the prefrontal, temporal, parietal and occipital lobes, and subcortical sites.…”

mentioning

confidence: 94%

“…Thus, we present in the manuscript the analyses with the standard stimuli modeled in the two-tone condition. Kiehl et al, 2001b;Kiehl & Liddle, 2003;Kiehl et al, 2005). One-sample t-statistics for each ROI for single-tone and two-tone conditions are reported as the maximum t-score within a priori ROIs.…”

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confidence: 99%

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The hemodynamics of oddball processing during single-tone and two-tone target detection tasks

Stevens

Laurens

Liddle

et al. 2006

International Journal of Psychophysiology

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Event-related potential (ERP) studies have shown that the neural systems engaged during performance of oddball tasks are sensitive to contextual manipulations, such as the number of stimulus classes. Some ERP components (i.e., N1) are modulated by the number of stimulus types, while others (i.e., P3) are not greatly affected. However, little is known about how these contextual manipulations affect the hemodynamics underlying oddball processing. The purpose of this study was to examine the hemodynamic correlates of target stimulus processing in singletone (targets alone) and two-tone (targets and standard tones) auditory oddball tasks. The primary hypothesis was that processing of salient stimuli in both contextual conditions would engage the same spatially distributed cortical and subcortical networks observed in previous oddball fMRI studies. Results were consistent with this hypothesis and suggest that the brain engages many potentially useful brain regions during salient stimulus processing despite the low probability that said regions are necessary for task performance, which likely reflects a form of "adaptive reflexive processing." Results also were consistent with ERP data that shows the N1 is larger for single-tone tasks by showing greater amplitude of hemodynamic response for singletone targets, relative to two tone targets, in bilateral temporal cortex and bilateral inferior lateral frontal cortex. The results are discussed as they relate to the understanding of neurocognitive function pertaining to contextual manipulations in general, and orienting processes in particular. Keywords ORIENTING; MAGNETIC RESONANCE IMAGING; BRAIN; PSYCHOLOGY; COGNITIONThe neural systems underlying processing of low probability target stimuli have been studied for over four decades. The impact of salient stimulus processing on brain electrical activity was first described by Sutton et al. (1965), who demonstrated that infrequently-presented taskrelevant stimuli ("oddballs") produce a sequence of time-locked electrical components, the NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript most prominent of which is a large positive potential that peaks approximately 300 milliseconds following the stimulus onset. This late event-related potential (ERP), termed the P300 or P3, is thought to reflect stimulus evaluation/categorization, and cognitive processes necessary to update mental models of context within working memory (Donchin & Coles, 1988). Since Sutton et al's seminal study, numerous reports have been published that detail how contextual manipulations in the oddball paradigm (e.g., manipulations of stimulus probability, inter-trial interval, sensory modality, etc.) modulate the latency, amplitude or topographic distribution of the P3 .One contextual manipulation to the oddball task is to alter the number of stimulus classes presented within the task. Researchers most commonly use oddball tasks having either twostimulus classes (low probability targets juxtaposed with frequent standards) or ...

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confidence: 72%

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

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confidence: 94%

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confidence: 99%

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The hemodynamics of oddball processing during single-tone and two-tone target detection tasks

Stevens

Laurens

Liddle

et al. 2006

International Journal of Psychophysiology

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“…The reasons for this difference are not known, although it could be due to greater task difficulty at Time 1, although inhibition performance at the two time points was not significantly different. There are also possible effects of novelty and habituation (Fischer et al, 2003;Kiehl and Liddle, 2003;Loubinoux et al, 2001) and procedural learning (Eliassen et al, 2001) that could account for these minor differences between Time 1 and Time 2. Another possibility is that the use of four separate trial blocks at Time 1 (i.e., a longer task with more events) and a larger participant pool resulted in a higher signal to noise ratio than with two blocks at Time 2, which would have enabled better differentiation of significantly active clusters and greater inhibition-related activation compared to baseline.…”

Section: Discussionmentioning

confidence: 99%

Frontal recruitment during response inhibition in older adults replicated with fMRI

2003

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Recent research has explored age-related differences in multiple areas of cognitive functioning using fMRI, PET, and SPECT. However, because these studies used different tasks, subjects, and methods, little is known about whether the results of these studies are generalizable or repeatable. The present study replicated a previous study [Psychol. Aging 17 (2002) 56] NOT THE PUBLISHED VERSION; this is the author's final, peer-reviewed manuscript. The published version may be accessed by following the link in the citation at the bottom of the page.NeuroImage, Vol 20, No. 2 (October 2003): pg. 1384-1392. DOI. This article is © Elsevier and permission has been granted for this version to appear in e-Publications@Marquette. Elsevier does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Elsevier. 2 using the same Go/No-go task with a subset of 11 of the original older adult subjects, and using the same fMRI scanner and imaging methods. A direct comparison was made between these participants at Time 1 and Time 2 for both behavioral and functional data. These participants were also compared to a new young adult group of 11 participants. Although the current young adult group did not perform as well as the original young adult group, the original finding of enhanced left prefrontal activation in older adults relative to younger adults was replicated. Furthermore, when comparing Time 1 to Time 2, older adults exhibited comparable areas of activation, but significantly greater magnitude of activation at Time 1 in a few clusters. The findings indicate that older adults exhibit more bilateral brain activity during this task than young adults, which appears compensatory and is repeatable over time. The magnitude of regional activation, however, may vary with extraneuronal factors such as signal-to-noise ratio or task experience. This study adds to existing research suggesting that bilateral frontal activation is a predominant finding in the aging literature, and not specific to certain tasks in age group comparisons.

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fNIRS‐based evaluation of the impact of SARS‐CoV‐2 infection central auditory processing

Yaman,

Yılmaz,

Hanoğlu

et al. 2023

Brain and Behavior

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ObjectivesCoronavirus disease‐2019 due to SARS‐CoV‐2 infection has been associated with neurological and neuropsychiatric illnesses as well as auditory system problems. In this study, we aimed to evaluate the impact of SARS‐CoV‐2 infection on the central auditory system by assessing the hemodynamic activation changes using functional near‐infrared spectroscopy (fNIRS).MethodsThree participants who had SARS‐CoV‐2 infection (study group) and four participants who had no SARS‐CoV‐2 infection (control group) were included in the study. During the auditory oddball task in which two different frequencies of tonal stimulation were presented at 80 dB HL, the participants were asked to pay attention to the rare tonal stimulation and mentally count these target stimuli throughout the task. During this task, oxygenated hemodynamic response functions were evaluated with fNIRS.ResultsSignificantly increased oxygenated hemodynamic responses were observed in both groups during the task (p < .05), which was significantly higher in the study group (p < .05). Significantly more HbO activation was observed in the vmPFC, superior temporal gyrus, and medial temporal gyrus in the study group compared to controls (p < .05). Significantly higher hemodynamic activation was observed in the right hemisphere in both groups, which was significantly higher in the study group (p < .05).ConclusionSARS‐CoV‐2 infections may impact on central auditory processing or auditory attention due to changes in oxyhemoglobin levels in the frontal and temporal brain regions. It seems that SARS‐CoV‐2 infection is associated with an additional load on neural activity, and difficulties in focusing in auditory attention, following speech and hearing in noise as well as increased effort to perceive auditory cues.

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Reproducibility of the hemodynamic response to auditory oddball stimuli: A six‐week test–retest study

Cited by 87 publications

References 57 publications

The hemodynamics of oddball processing during single-tone and two-tone target detection tasks

The hemodynamics of oddball processing during single-tone and two-tone target detection tasks

Frontal recruitment during response inhibition in older adults replicated with fMRI

fNIRS‐based evaluation of the impact of SARS‐CoV‐2 infection central auditory processing

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