Reproducibility of Serum 25-Hydroxyvitamin D and Vitamin D-Binding Protein Levels Over Time in a Prospective Cohort Study of Black and White Adults

Sonderman, Jennifer S.; Munro, Heather M.; Blot, William J.; Signorello, Lisa B.

doi:10.1093/aje/kws141

Cited by 82 publications

(64 citation statements)

References 30 publications

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“…Although high intra-individual reproducibility of serum 25(OH)D levels over time has been reported [35], the use of single serum 25(OH)D levels is one limitation of our study. Regarding smoking status, although a direct measure can be obtained by measuring cotinine levels in biological fluids, most population studies, including the HUNT Study, rely on self-report.…”

Section: Discussionmentioning

confidence: 91%

Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study

et al. 2015

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The association between serum 25-hydroxyvitamin D (25(OH)D) level and lung function changes in the general population remains unclear.We conducted cross-sectional (n=1220) and follow-up (n=869) studies to investigate the interrelationship of serum 25(OH)D, smoking and lung function changes in a random sample of adults from the Nord-Trøndelag Health (HUNT) Study, Norway.Lung function was measured using spirometry and included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % pred and FEV1/FVC ratio. Multiple linear and logistic regression models estimated the adjusted difference in lung function measures or lung function decline, adjusted odds ratios for impaired lung function or development of impaired lung function and 95% confidence intervals.40% of adults had serum 25(OH)D levels <50 nmol·L −1. Overall, those with a serum 25(OH)D level <50 nmol·L −1 showed worse lung function and increased odds of impaired lung function compared to the ⩾50 nmol·L −1 group. These associations tended to be stronger among ever-smokers, including greater decline in FEV1/FVC ratio and greater odds of the development of impaired lung function (FEV1/FVC <70% OR 2.4, 95% CI 1.2-4.9). Associations among never-smokers were null. Results from cross-sectional and follow-up studies were consistent. There were no associations between serum 25(OH)D levels and lung function or lung function changes in never-smokers, whereas significant associations were observed in ever-smokers.

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Section: Discussionmentioning

confidence: 91%

Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study

et al. 2015

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“…However, results from a recent prospective study in the US suggested high intra-individual reproducibility over time [30]. We excluded 15% of asthma cases due to missing data on exposure and/or outcomes which may lead to selection bias.…”

Section: Discussionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study

et al. 2014

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The association between vitamin D status and lung function in adults with asthma remains unclear.We studied this cross-sectional association and possible modification by sex and allergic rhinitis in 760 adults (aged 19-55 years) with self-reported asthma in the Nord-Trøndelag Health Study. Serum 25-hydroxyvitamin D (25(OH)D) level <50 nmol·L −1 was considered deficient. Lung function measurements included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % predicted and FEV1/FVC ratio. Multiple linear regression models were used to estimate adjusted regression coefficients (β) and 95% confidence intervals.44% of asthma adults had serum 25(OH)D levels <50 nmol·L −1. Its associations with lung function measures seemed to be modified by sex and allergic rhinitis ( p<0.03 for three-way interaction term). Overall, a serum 25(OH)D level <50 nmol·L −1 was not associated with lung function measurements in subjects with allergic rhinitis in this asthma cohort. In men with asthma but without allergic rhinitis, however, a serum 25(OH)D level <50 nmol·L −1 was significantly associated with lower FEV1/FVC ratio (β=−8.60%; 95% CI: −16.95%-−0.25%).Low serum 25(OH)D level was not associated with airway obstruction in most asthma adults with the exception of men with asthma but without allergic rhinitis. @ERSpublications Low 25(OH)D levels were not associated with airway obstruction in most asthma adults except for men with no allergy

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“…For example, in preschool children in the UK, mean 25(OH)D was approximately 70% higher in summer compared to winter [16], yet the potential tracking of 25(OH)D throughout the year has not been elucidated. Reproducibility of 25(OH)D status in samples obtained in the same month at one to 5 year intervals has been demonstrated in adults [104,105]. However, stability in the rank of an individual's 25(OH)D measurement within the population distribution at several time points during childhood/adolescence or across seasons is unknown.…”

Section: Vitamin D Status and Bmd In Childhood And Adolescencementioning

confidence: 99%

Vitamin D and skeletal health in infancy and childhood

et al. 2014

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During growth, severe vitamin D deficiency in childhood can result in symptomatic hypocalcaemia and rickets. Despite the suggestion from some studies of a secular increase in the incidence of rickets, this observation may be driven more by changes in population demographics than a true alteration to age, sex and ethnicity-specific incidence rates; indeed rickets remains uncommon overall and is rarely seen in fair-skinned children. Additionally, the impact of less severe vitamin D deficiency and insufficiency has received much interest in recent years, and in this review we consider the evidence relating vitamin D status to fracture risk and bone mineral density (BMD) in childhood and adolescence. We conclude that there is insufficient evidence to support the suggestion that low serum 25-hydroxyvitamin D [25(OH)D] increases childhood fracture risk. Overall, the relationship between 25(OH)D and BMD is inconsistent across studies and across skeletal sites within the same study; however there is evidence to suggest that vitamin D supplementation in children with the lowest levels of 25(OH)D might improve BMD. High quality randomised trials are now required to confirm this benefit.

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Reproducibility of Serum 25-Hydroxyvitamin D and Vitamin D-Binding Protein Levels Over Time in a Prospective Cohort Study of Black and White Adults

Cited by 82 publications

References 30 publications

Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study

Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study

Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study

Vitamin D and skeletal health in infancy and childhood

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