Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study

Larose, Tricia L; Chen, Yue; Camargo, Carlos A.; Romundstad, Pål Richard; Mai, Xiao-Mei

doi:10.1183/09031936.00069714

Cited by 21 publications

(19 citation statements)

References 32 publications

(36 reference statements)

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“…16 However findings of this study were consistent with HUNT study that concluded that low serum 25(OH)D level was not associated with airway obstruction in most asthma adults. 17 The current study showed lack of seasonal variation in vitamin D levels which were consistent with a study from Iran. 18 However many other studies reported seasonal variation with an increase in value in the summer season.…”

Section: Discussionsupporting

confidence: 92%

Assessment and evaluation of vitamin D levels in patients of moderate persistent asthma: a prospective study in rural hilly area

Sood

2016

Int J Adv Med

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INTRODUCTIONVitamin D is a lipid soluble vitamin that acts as a hormone playing a pivotal role in Ca 2+ homeostasis. It acts through nuclear receptors called vitamin D receptors (VDR). The principal provitamin found in humans is 7-dehydrocholesterol, synthesized in skin. UV exposure of skin converts it to cholecalciferol (vitamin D 3 ). Further, D 3 gets converted by 25-hydroxylation in the liver to 25-OH D 3.Finally 1-α-hydroxylation takes place in the kidney (rate limiting step) and 1α, 25-(OH) 2 D 3 or calcitriol is formed.Calcitriol stimulates intestinal calcium and phosphate absorption and with its interplay with parathyroid hormone (PTH) maintains normal plasma Ca 2+ concentrations from bone mobilization through bone growth, bone resorption and remodeling. It also raises plasma Ca 2+ levels by decreasing its renal excretion and by increasing proximal tubular reabsorption.VDRs are distributed widely throughout the body and believed to be involved in the regulation of cell growth, differentiation and apoptosis as well as modulation of the immune system by influencing cytokine production and other functions. 1 ABSTRACT Background:The discovery of non-classical actions of vitamin D has opened new applications. Among these is its anti-inflammatory role in inflammatory diseases like asthma. Low levels of vitamin D have been associated with asthma severity and recurrent exacerbations. Emerging evidence suggests that vitamin D deficiency (VDD) is also associated with increased airway hyper-responsiveness, decreased pulmonary function and decreased response to standard anti-asthma therapy. Methods: In this prospective study, vitamin D levels were assessed in 50 consecutive consenting subjects of moderate persistent asthma diagnosed as per GINA guidelines. Levels were assessed in relation to exacerbations, seasonal variation in spring, rainy and winter season and lung function. Results: 62% subjects were having deficient levels of 25 (OH) Vitamin D (<20 ng/ml). None of study participant had sufficient levels of vitamin D. There was lack of seasonal effect due to variation in sun exposure in different seasons on levels of vitamin D. This study found no correlation (r=0.078) between levels of vitamin D and number of exacerbations in patients of asthma on regular treatment. In subjects groups having less and more than 3 exacerbations in nine months, difference of vitamin D levels and lung function was also statistically not significant. Conclusions: Findings of this study were consistent with HUNT study that concluded non association of low serum 25 (OH) D levels with airway obstruction. However, considerable variation in different study results with regard to seasonal, lung function and exacerbational variation underline the need for a meta-analysis in this field.

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Section: Discussionsupporting

confidence: 92%

Assessment and evaluation of vitamin D levels in patients of moderate persistent asthma: a prospective study in rural hilly area

Sood

2016

Int J Adv Med

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“…Serum 25(OH)D levels were categorised based on the most recent Institute of Medicine report (<50 or ⩾50 nmol·L −1 ) [11], or used as a continuous independent variable. As previously described [12], spirometry was performed by trained health professionals at screening stations. Instrument quality control was conducted once daily via staff lung function assessment.…”

Section: Methodsmentioning

confidence: 99%

Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study

et al. 2015

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The association between serum 25-hydroxyvitamin D (25(OH)D) level and lung function changes in the general population remains unclear.We conducted cross-sectional (n=1220) and follow-up (n=869) studies to investigate the interrelationship of serum 25(OH)D, smoking and lung function changes in a random sample of adults from the Nord-Trøndelag Health (HUNT) Study, Norway.Lung function was measured using spirometry and included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % pred and FEV1/FVC ratio. Multiple linear and logistic regression models estimated the adjusted difference in lung function measures or lung function decline, adjusted odds ratios for impaired lung function or development of impaired lung function and 95% confidence intervals.40% of adults had serum 25(OH)D levels <50 nmol·L −1. Overall, those with a serum 25(OH)D level <50 nmol·L −1 showed worse lung function and increased odds of impaired lung function compared to the ⩾50 nmol·L −1 group. These associations tended to be stronger among ever-smokers, including greater decline in FEV1/FVC ratio and greater odds of the development of impaired lung function (FEV1/FVC <70% OR 2.4, 95% CI 1.2-4.9). Associations among never-smokers were null. Results from cross-sectional and follow-up studies were consistent. There were no associations between serum 25(OH)D levels and lung function or lung function changes in never-smokers, whereas significant associations were observed in ever-smokers.

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“…Furthermore, instead of measuring cord serum 25(OH)D, both KOALA and Canadian studies determined the level of 25(OH)D during preschool or school age. Regarding to the relationship between 25(OH)D and lung function in adults, the HUNT study revealed that low serum 25(OH)D level was not associated with airway obstruction in most asthma adults with the exception of males with asthma but without allergic rhinitis [36]. Therefore, drawing conclusions about the effects of perinatal and postnatal vitamin D status from these results can be difficult.…”

Section: Discussionmentioning

confidence: 99%

Low cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy

et al. 2017

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BackgroundPerinatal vitamin D deficiency is associated with a higher risk of wheezing in childhood. However, the relationship between vitamin D levels and lung function in infancy has not been investigated. The aim of this study was to investigate the impact of perinatal vitamin D levels on respiratory function and disease outcome in infancy.Materials and methodsFull-term infants without any chronic diseases or major anomalies were enrolled in the Prediction of Allergies in Taiwanese Children cohort study. Maternal and cord blood were collected for determining the 25(OH)D level. Questionnaires were recorded at birth and 6 months of age. Infant lung function, including tidal breathing analysis, respiratory mechanics, and forced tidal expiration, was tested at 6 months of age.ResultsA total of 122 mother—infant pairs were enrolled in this study, and 71 infants underwent lung function testing at 6 months of age. 25(OH)D levels in maternal and cord serum were highly correlated (r2 = 0.457, p < 0.0001). Infants with lower cord serum 25(OH)D levels (< 13.7 ng/ml) had higher resistance of respiratory system (p < 0.01) and a higher risk of a respiratory tract infection before the age of 6 months (p < 0.01).ConclusionAlthough a high correlation was found between maternal and cord vitamin D levels, the effect on respiratory outcome was different. Our study is the first to show that low cord 25(OH)D levels significantly relationship with poorer lung function performance and higher likelihood of a respiratory tract infection before 6 months of age.

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Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study

Cited by 21 publications

References 32 publications

Assessment and evaluation of vitamin D levels in patients of moderate persistent asthma: a prospective study in rural hilly area

Assessment and evaluation of vitamin D levels in patients of moderate persistent asthma: a prospective study in rural hilly area

Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study

Low cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy

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