Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position

Abstract

In whole breast and regional nodal irradiation (WB + RNI), breathhold increases organ at risk (OAR) sparing. WB + RNI is usually performed in supine position, because positioning materials obstruct beam paths in prone position. Recent advancements allow prone WB + RNI (pWB + RNI) with increased sparing of OARs compared to supine WB + RNI. We evaluate positional and dosimetrical impact of repeated breathhold (RBH) and failure to breathhold (FTBH) in pWB + RNI. Twenty left-sided breast cancer patients were scanned twice in breathhold (baseline and RBH) and once free breathing (i.e. FTBH). Positional impact was evaluated using overlap index (OI) and Dice similarity coefficient (DSC). Dosimetrical impact was assessed by beam transposition from the baseline plan. Mean OI and DSC ranges were 0.01–0.98 and 0.01–0.92 for FTBH, and 0.73–1 and 0.69–1 for RBH. Dosimetric impact of RBH was negligible. FTBH significantly decreased minimal dose to CTV WBI, level II and the internal mammary nodes, with adequate mean doses. FTBH significantly increased heart, LAD, left lung and esophagus dose. OI and DSC for RBH and FTBH show reproducible large ROI positions. Small ROIs show poor overlap. FTBH maintained adequate target coverage but increased heart, LAD, ipsilateral lung and esophagus dose. RBH is a robust technique in pWB + RNI. (Clinicaltrials.gov: NCT05179161, registered 05/01/2022).

Four irradiation and three positioning techniques for whole‐breast radiotherapy: Is sophisticated always better?

“…This trend is similar to the outcomes of earlier WBI + LNI studies on the effects of DIBH in the prone crawl position, with a 40% heart dose reduction compared to SB 15 . Previous studies at our center further confirmed the reproducibility of DIBH for both prone dive (WBI) 38 and prone crawl (WBI + LNI) 39 …”

“… 15 Previous studies at our center further confirmed the reproducibility of DIBH for both prone dive (WBI) 38 and prone crawl (WBI + LNI). 39 …”

“…15 Previous studies at our center further confirmed the reproducibility of DIBH for both prone dive (WBI) 38 and prone crawl (WBI + LNI). 39 Irradiation of lung structures is associated with lung fibrosis, pneumonitis, and secondary lung cancers. 40 These acute and late side effects are particularly important for early-stage and young patients who have a high probability of long-term breast cancer survival, 4 and for patients with pulmonary risk factors.…”