Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD

Adami, Alessandra; Cao, Robert; Pórszász, János; Casaburi, Richard; Rossiter, Harry B.

doi:10.1016/j.resp.2016.09.008

Cited by 42 publications

(81 citation statements)

References 40 publications

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“…Under this rubric, three underlying concepts can be addressed: the intersite and interindividual differences discussed early, as well as change in muscle activation from a passive AOM test to an AOM test under active conditions or interactivation differences. These approaches have been examined using NIRS, 24,25 including a study by Lacroix et al 26 using the AOM to investigate the NIRS reproducibility during brachial artery occlusions yielding a high degree of reproducibility.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy-derived muscle oxygen saturation on a 0% to 100% scale: reliability and validity of the Moxy Monitor

Feldmann

Schmitz²,

Erlacher

2019

J. Biomed. Opt.

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Near-infrared spectroscopy (NIRS) to monitor muscle oxygen saturation (SmO 2) is rapidly expanding into applied sports settings. However, the technology is limited due to its inability to convey quantifiable values. A test battery to assess reliability and validity of a 0% to 100% scale modeled by a commercially available NIRS device was established. This test battery applies a commonly used technique, the arterial occlusion method (AOM) to assess repeatability, reproducibility, and face validity. A total of 22 participants completed the test battery to scrutinize the 0% to 100% scale provided by the device. All participants underwent repeated AOM tests in passive and active conditions. The SmO 2 minimum and SmO 2 maximum values were obtained from the AOM and were used in the subsequent analysis. Repeatability and reproducibility were tested for equivalency and Bland-Altman plots were generated. Face validity was assessed by testing SmO 2 values against an a priori defined threshold for mixed venous blood during AOM response. The device exhibits an appropriately functional 0% to 100% scale that is reliable in terms of repeatability and reproducibility. Under the conditions applied in the test battery design, the device is considered valid for application in sports.

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Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy-derived muscle oxygen saturation on a 0% to 100% scale: reliability and validity of the Moxy Monitor

Feldmann

Schmitz²,

Erlacher

2019

J. Biomed. Opt.

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“…Near-infrared spectroscopy (NIRS) emerged as an non-invasive method to evaluate oxidative capacity and blood flow and metabolism on skeletal muscle in patients with COPD (Adami et al, 2017;Louvaris et al, 2017). Previously, an early study described the potential applicability of NIRS during exercise training programmes (Puente-Maestu et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Training‐induced changes on quadriceps muscle oxygenation measured by near‐infrared spectroscopy in healthy subjects and in chronic obstructive pulmonary disease patients

Barberán-García

Muñoz

Gimeno‐Santos

et al. 2019

Clin Physio Funct Imaging

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Summary Aim We hypothesize that training‐induced changes in muscle oxygen saturation (StO2) assessed by near‐infrared spectroscopy (NIRS) during constant work rate cycling exercise (CWRE) may be a useful marker of the effects of training at ‘vastus medialis’ of the quadriceps in patients with chronic obstructive pulmonary disease (COPD). Methods Incremental exercise [peak oxygen uptake (VO2)] and CWRE at 70% pretraining peak VO2, before and after 8‐w training, were done in 10 healthy age‐matched subjects (H) [80% men, 65(11) years, FEV1 105(14)%] and 16 COPD patients [94% men, 70(5) years, FEV1 46(11) %] encompassing the entire spectrum of disease severity, recruited in the outpatient clinics. NIRS was used to assess StO2 in the ‘vastus medialis’ of the left quadriceps. Results Pretraining CWRE decreased StO2 (P<0·05) and generated marked StO2 rebound (P<0·001) after unloading in the two groups. After training, VO2 peak increased in H [253(204) ml min−1] (P<0·01) and in COPD [180(183) ml·min−1] (P = 0·01) and blood lactate fell [−4·4 (2·7) and −1·6(2·3) mmol·m−1] (P<0·05 each). Training generated a further fall in StO2 during CWRE [−10(12)% and −10(10)%, P<0·05] and increased StO2 rebound after unloading [8(7)% and 5(9)%, P<0·05] in both groups. Conclusion Endurance training further decreased StO2 during CWRE, similarly in both groups, likely due to training‐induced enhancement of muscle O2 transfer and utilization. Training‐induced StO2 fall during CWRE may be useful individual marker for non‐invasive assessment of enhanced muscle aerobic post‐training function.

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“…The primary finding of this study was that rate constant of recovery of metabolic rate after exercise was not different when calculated from a reduced number of data points (Mito6) compared to a full set of data points (Mito22). Previous studies have measured muscle mitochondrial capacity using exercise to rest transitions and curve fitting similar to the Mito22 used in this study [6,12].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, muscle mitochondrial capacity been characterized in multiple specific disease pathologies such as those with spinal cord injuries [8], cystic fibrosis [9], multiple sclerosis [10], and amyotrophic lateral sclerosis [11]. Several review papers have been written on this subject [6,12].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of 6-Ischemic Cuff Near Infrared Spectroscopy Mitochondrial Capactity Test

M¹,

Das²,

Ek³

et al. 2019

Preprint

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Near-Infrared Spectroscopy (NIRS) has been used to measure muscle mitochondrial capacity. The current method requires as many as 22 short ischemic occlusions to generate a recovery curve for mitochondrial capacity.  PURPOSE: To determine the effectiveness of using a 6-occlusion analysis protocol to study muscle mitochondrial capacity.  METHOD: Two independent, unidentified data sets were analyzed (bicep n=48, forearm n=41) from previous studies using a NIRS device (Artinis, Ltd.). Both data sets had two recovery tests that included 22 ischemic occlusions.  A recovery rate used to indicate mitochondrial capacity was calculated two different ways (simultaneously).  Each sample was analyzed with a MATLAB program; with a curve-fit for the 22 ischemic occlusions and curve matching for the first six ischemic cuffs and an end resting value. The two resulting rate constants were compared using correlations, both for the two data sets, good and bad fitting data, using the best 5 of 6 points for the 6 cuff approach.  RESULTS: The rate constants were not significantly different between the 22 cmuff and 6 cuff for the total data sets:  bicep (1.43+0.32min-1, 1.44+0.35min-1, p=0.56), forearm (1.94+0.42min-1, 1.95+0.44min-1, p=0.76). The average bicep rate constants, when compared to each other, had an equation of y=1.07x-0.09, R2=0.90. The average forearm rate constants, when compared to each other, had an equation of 0.98x+0.02, R2=0.93. CONCLUSIONS: The 6-Cuff analysis provided the same results as the longer 22-cuff. The 6-cuff approach is both shorter in time and uses less ischemic occlusion periods, increasing the practicality of the NIRS mitochondrial capacity test.

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Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD

Cited by 42 publications

References 40 publications

Near-infrared spectroscopy-derived muscle oxygen saturation on a 0% to 100% scale: reliability and validity of the Moxy Monitor

Near-infrared spectroscopy-derived muscle oxygen saturation on a 0% to 100% scale: reliability and validity of the Moxy Monitor

Training‐induced changes on quadriceps muscle oxygenation measured by near‐infrared spectroscopy in healthy subjects and in chronic obstructive pulmonary disease patients

Effectiveness of 6-Ischemic Cuff Near Infrared Spectroscopy Mitochondrial Capactity Test

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