Reproducibility of methods used for the assessment of autonomous nervous system's function

Abstract

Some tests that assess HRV showed adequate reproducibility. This study allows the determination of a sample size calculation for longitudinal or drug-testing studies.

Reproducibility of Heart Rate Variability Revealed by Repeated Measurements during and after Hemodialysis

“…Numerous studies have been performed to test the reliability of short-term HRV (5 min) in non-HD populations. These studies have shown poor reliability [26][27][28][29] presumably related to higher short-term variability like our data. Whether such variability carries a predictive value for major clinical events cannot be addressed by our study because no IME did occur in our cohort.…”

Heart rate variability and plasma biomarkers in patients with type 1 diabetes mellitus: Effect of a bout of aerobic exercise

“…Indeed, previous studies failed to demonstrate any changes in this important oxidant enzymatic defense [23,24,30]. A number of studies have shown an autonomic imbalance in people with diabetes with alterations in time domain components, with lower SDNN and PNN50 [31,32], as well as lower oscillations in HF components that reflect parasympathetic tone, and a marked prevalence in sympathetic tone, evaluated by LF components [10,12,33]. In accordance with previous studies, we found a significant reduction in time domain components (means RR and SDNN) at baseline, but no changes in LF or HF components.…”

“…Increased sympathetic and/or decreased parasympathetic activities have been associated with high risk of sudden death. Indeed, several studies have shown that patients with T1DM and T2DM showed autonomic dysfunction [10][11][12]. Interestingly, most studies have focused on patients with T2DM and only a few studies have investigated T1DM and autonomic dysfunction.…”

Repeatability and Reliability of Heart Rate Variability in Healthy, Adult Pony Mares

“…These studies indicated that inconsistent results can be expected with data sampling at different times of the day [25], presence of heart disorders or unhealthy participants [25,28], gender differences [26], or when different HRV indicators are used for monitoring the autonomic system [26].…”

“…Studies in humans showed that standardization of methodology is important to assure inter-and intra-study repeatability of HRV measurements [25][26][27][28][29].…”