Reproducibility of Full-field Electroretinogram Measurements in Birdshot Chorioretinopathy Patients: An Intra- and Inter-visit Analysis

Knickelbein, Jared E.; Jeffrey, Brett G.; Wei, Maggie; Cheng, Shuk Kei; Kesav, Natasha; Vitale, Susan; Sen, H. Nida

doi:10.1080/09273948.2019.1697824

Cited by 4 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More specifically, an increased 30 Hz implicit time seems to correlate with retinal vasculitis and to reflect ongoing disease activity. [57][58][59][60][61][62][63][64][65][66] We could not confirm this finding, as the 30 Hz implicit time did not reach significance after 1 year of treatment, neither did any other ERG parameter. Furthermore, ERG is technically demanding and very uncomfortable to the patient.…”

Section: Clinical Sciencementioning

confidence: 80%

Efficacy and safety of abatacept to treat active birdshot uveitis: a prospective open label interventional proof-of-concept trial

Schauwvlieghe

Calster

Herbort³

et al. 2022

Br J Ophthalmol

View full text Add to dashboard Cite

Background/aimsBirdshot uveitis (BU) is a chronic autoimmune posterior uveitis, mostly affecting middle-aged Caucasians. There is a strong association with HLA-A29 and T-cell activation. Safety and efficacy of abatacept, an inhibitor of T-cell costimulation, is tested in active BU.MethodsFifteen patients with active BU were treated with monotherapy of weekly subcutaneous injections of abatacept 125 mg/mL. Time-to-treatment failure was evaluated as a primary outcome. The secondary objective was to evaluate the utility of different outcome measures to monitor disease activity. Safety was evaluated by adverse event reporting and serial blood analyses.ResultsAt the year-1 endpoint, there was significant improvement in vitreous haze grade (p=0.0014), central choroidal thickness (CCT) (p=0.0011), Fluorescein Angiography (FA) Score (p=0.0014), Indocyanine Green Angiography (ICGA) Score (p<0.001) and total dual FA-ICGA Score (p<0.001). Best corrected visual acuity (BCVA) (p=0.8354) and central retinal thickness (CRT) (p=0.3549) did not change significantly. There were no serious adverse events reported. In total, 4 out of 15 patients left the trial during year 1 of whom 2 experienced treatment failure.ConclusionsAbatacept is very efficacious to treat both retinal vasculitis and choroiditis in patients with BU and is well tolerated. BCVA and CRT are inadequate to monitor disease activity. On the other hand, CCT is a promising non-invasive tool to detect treatment response in early active BU and dual FA-ICGA Score is very helpful to evaluate retinal vasculitis and choroiditis quantitatively.Trial registration numberNCT03871361.

show abstract

Section: Clinical Sciencementioning

confidence: 80%

Efficacy and safety of abatacept to treat active birdshot uveitis: a prospective open label interventional proof-of-concept trial

Schauwvlieghe

Calster

Herbort³

et al. 2022

Br J Ophthalmol

View full text Add to dashboard Cite

show abstract

“…Full field ERGs (ffERGs) were recorded in accordance with the 2008 version of the International Society for Clinical Electrophysiology of Vision (ISCEV) standard ( Marmor et al, 2009 ) as described in detail previously ( Knickelbein et al, 2020 ). Briefly, the patient was dark-adapted for 30 min prior to the start of the ERG testing.…”

Section: Methodsmentioning

confidence: 99%

Persistent Dark Cones in Oligocone Trichromacy Revealed by Multimodal Adaptive Optics Ophthalmoscopy

Liu

Flynn

et al. 2021

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

Dark cone photoreceptors, defined as those with diminished or absent reflectivity when observed with adaptive optics (AO) ophthalmoscopy, are increasingly reported in retinal disorders. However, their structural and functional impact remain unclear. Here, we report a 3-year longitudinal study on a patient with oligocone trichromacy (OT) who presented with persistent, widespread dark cones within and near the macula. Diminished electroretinogram (ERG) cone but normal ERG rod responses together with normal color vision confirmed the OT diagnosis. In addition, the patient had normal to near normal visual acuity and retinal sensitivity. Occasional dark gaps in the photoreceptor layer were observed on optical coherence tomography, in agreement with reflectance AO scanning light ophthalmoscopy, which revealed that over 50% of the cones in the fovea were dark, increasing to 74% at 10° eccentricity. In addition, the cone density was 78% lower than normal histologic value at the fovea, and 20–40% lower at eccentricities of 5–15°. Interestingly, color vision testing was near normal at locations where cones were predominantly dark. These findings illustrate how a retina with predominant dark cones that persist over at least 3 years can support near normal central retinal function. Furthermore, this study adds to the growing evidence that cones can continue to survive under non-ideal conditions.

show abstract

Birdshot Chorioretinopathy

Sen¹

2020

Whitcup and Nussenblatt's Uveitis

View full text Add to dashboard Cite

Reproducibility of Full-field Electroretinogram Measurements in Birdshot Chorioretinopathy Patients: An Intra- and Inter-visit Analysis

Cited by 4 publications

References 25 publications

Efficacy and safety of abatacept to treat active birdshot uveitis: a prospective open label interventional proof-of-concept trial

Efficacy and safety of abatacept to treat active birdshot uveitis: a prospective open label interventional proof-of-concept trial

Persistent Dark Cones in Oligocone Trichromacy Revealed by Multimodal Adaptive Optics Ophthalmoscopy

Birdshot Chorioretinopathy

Contact Info

Product

Resources

About