Reproducibility of colonic transit study in patients with chronic constipation

Nam, Young-Soo; Pikarsky, Alon J.; Wexner, Steven D.; Singh, Jay J.; Weiss, Eric G.; Nogueras, Juan J.; Choi, Jeong Seok; Hwang, Yong-Hee

doi:10.1007/bf02234827

Cited by 66 publications

(41 citation statements)

References 25 publications

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“…18 Several techniques have been used to measure CTT in patients with gastrointestinal disorders and have proved to be reliable and reproducible. 19 In our study we used the three day Metcalf marker method. x Ray examinations were repeated with a three day interval until more than 80% of the markers disappeared.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of constipation: clinical factors and colonic transit time

Lorijn

Wijk

Reitsma³

et al. 2004

Archives of Disease in Childhood

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Background: Measurement of colonic transit time (CTT) is sometimes used in the evaluation of patients with chronic constipation. Aim: To investigate the relation between symptoms and CTT, and to assess the importance of symptoms and CTT in predicting outcome. Methods: Between 1995 and 2000, 169 consecutive patients (median age 8.4 years, 65% boys) fulfilling the criteria for constipation were enrolled. During the intervention and follow up period, all kept a diary to record symptoms. CTT was measured at entry to the study. Results: At entry, defecation frequency was lower in girls than in boys, while the frequency of encopresis episodes was higher in boys. CTT values were significantly higher in those with a low defecation frequency ((1/week) and a high frequency of encopresis (>2/day). However, 50% had CTT values within the normal range. Successful outcome occurred more often in those with a rectal impaction. CTT results ,100 hours were not predictive of outcome. However, those with CTT .100 hours were less likely to have had a successful outcome. Conclusion: The presence of a rectal impaction at presentation is associated with a better outcome at one year. A CTT .100 hours is associated with a poor outcome at one year.

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Section: Discussionmentioning

confidence: 99%

Prognosis of constipation: clinical factors and colonic transit time

Lorijn

Wijk

Reitsma³

et al. 2004

Archives of Disease in Childhood

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“…Colonic transit study : A single capsule containing 24 radio-opaque markers (Sitzmarks®, Konsyl Pharmaceuticals, Fort Worth, Texas) was administered on day 1 and a plain abdominal x-ray was obtained on day 6 (120 hours later)(14)(15)(16). Retention of > 20% markers (>6 markers) on day 6 (120 hrs) was considered abnormal (16) and indicative of slow transit constipation.…”

Section: Methodsmentioning

confidence: 99%

Methanogenic Flora Is Associated With Altered Colonic Transit but Not Stool Characteristics in Constipation Without IBS

Attaluri

Jackson

Valestin

et al. 2010

American Journal of Gastroenterology

220

151

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Background: About 35% of humans have methane producing gut flora. Methane-producing IBS subjects were generally constipated. In animal models, methane infusion slows intestinal transit. Whether methanogenic flora alters colonic transit or stool characteristics and its relationship to constipation is unclear. Aim: To examine the prevalence and association of methanogenic flora in patients with slow transit constipation (ST) and normal transit constipation (NT) and non-constipated controls. Methods: Ninety six consecutive subjects with chronic constipation (Rome III) were evaluated with radio-opaque marker (ROM) transit studies and were classified as slow transit (>20% ROM retention) or normal transit. All constipated subjects and 106 non constipated controls underwent breath tests to assess methane production. Baseline CH4 of ≥ 3 ppm was used to define presence of methanogenic flora. Stool frequency and consistency were assessed using a prospective stool diary. Correlation analyses were performed. Results: Forty eight subjects had ST and 48 had NT. Prevalence of methanogenic flora was higher (p < 0.05) in ST (75%) compared to NT (44%) or controls (28%). ST patients had higher methane production compared to NT and controls (p<0.05). NT patients also produced more methane compared to controls (p < 0.05). There was moderate(p<0.05) correlation between baseline, peak and AUC of methane response with colonic transit but not with stool characteristics. Conclusions: Presence of methanogenic flora is associated with chronic constipation. Methane production following carbohydrate challenge and its prevalence were higher in ST than NT, although stool characteristics were similar in both groups. Methane production correlated with colonic transit, suggesting an association with stool transport but not with stool characteristics.

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“…Women were considered to have constipation if they had less than three times a week defecation with excessive straining. 4 The data of the second part of questionnaire were obtained by examination. Pelvic organ prolapse was determined by using the pelvic organ prolapse quantification (POPQ) system.…”

Section: Methodsmentioning

confidence: 99%

Rate and related factors of dyspareunia in reproductive age women: a cross-sectional study

Sobhgol

Charndabee

2006

Int J Impot Res

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This study was conducted to determine rate and related factors of dyspareunia. Three hundred and nineteen women aged 15-49 years were surveyed. A questionnaire was used to collect data. Pelvic examinations and connective tissue disorders were investigated. At whole 54.5% had dyspareunia. The means of gravidity, parity, delivery without episiotomy and vaginal length were more in women with dyspareunia. Heavy lifting, chronic pulmonary obstructive disease, arthritis, constipation, pelvic organ prolapse and pelvic muscle strength had significant relation to dyspareunia. The prevalence of urinary infection, stress incontinence, urgency, positional changes to start or complete voiding, fecal straining, low back pain, digital manipulation of vagina, perineum or anus to complete defecation, feeling genital pain or pressure and sensation of a mass in vagina was more in women with dyspareunia. These factors can be considered in the evaluation of women, to prevent those at risk and also have better management of this disorder.

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Reproducibility of colonic transit study in patients with chronic constipation

Cited by 66 publications

References 25 publications

Prognosis of constipation: clinical factors and colonic transit time

Prognosis of constipation: clinical factors and colonic transit time

Methanogenic Flora Is Associated With Altered Colonic Transit but Not Stool Characteristics in Constipation Without IBS

Rate and related factors of dyspareunia in reproductive age women: a cross-sectional study

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