Reproducibility of blood flow velocity measurements using colour decoded Doppler imaging

Matthiessen, E.T.; Zeitz, Oliver; Richard, Gisbert; Klemm, M.

doi:10.1038/sj.eye.6700651

Cited by 72 publications

(59 citation statements)

References 20 publications

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“…17 In our laboratory, we reach acceptable reproducibility of the CDI measurements by maximal standardization of the CDI procedure. 18 Compared to previous reports, the diameter of the OA as well as that of the CRA appears to be slightly overestimated. 10,19 In the article from Orge et al, the OA diameter was 2.0270.46 mm, and in our study, 2.2170.31 mm.…”

Section: Discussioncontrasting

confidence: 56%

Volumetric colour Doppler imaging: a useful tool for the determination of ocular blood flow in glaucoma patients?

Zeitz

Vilchez

Matthiessen

et al. 2005

Eye

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Purpose Disturbed ocular haemodynamics are discussed to contribute to the pathogenesis of glaucoma. Up to now there is no method available allowing direct determination of blood flow, which is the most relevant dimension for studies on haemodynamics. In this study, volumetric colour Doppler imaging (vCDI) is evaluated systematically in glaucoma patients. Methods A Siemens Elegra ultrasound set-up with a linear 7.5 MHz probe was used for all CDI measurements. For vCDI, the crosssectional area of a vessel and the flow velocity is determined. From both these parameters blood flow can be calculated. Ocular pulse amplitude (OPA) was assessed by the method of Langham using a pneumatic applanation tonometer. Results (1) Velocity measurements using CDI in the ophthalmic artery and central retinal artery were highly reproducible (n ¼ 20). In contrast, reproducibility of vCDI measurements was low (n ¼ 20). Reproducibility improved if five vCDI measures were averaged. (2) Results from two different CDI-operators did not differ regarding the velocity measurements, but there was a difference in vCDI measurements (n ¼ 20). (3) Results from vCDI did not correlate with measurements of OPA in 69 patients. (4) In 15 patients, vCDI failed to detect changes of ocular perfusion induced by the application of dorzolamide. Conclusion vCDI is not applicable in ophthalmology at present.

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Section: Discussioncontrasting

confidence: 56%

Volumetric colour Doppler imaging: a useful tool for the determination of ocular blood flow in glaucoma patients?

Zeitz

Vilchez

Matthiessen

et al. 2005

Eye

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“…As a matter of fact, CDI devices are widely used in medicine and the technique has shown good reproducibility, after adequate training, even for measurements of retrobulbar blood flow velocity obtained by the same observer in the same patient [15,16].…”

Section: Discussionmentioning

confidence: 99%

Inter-device reproducibility of retrobulbar blood flow velocity measurements in healthy subjects using color Doppler imaging

C.¹,

Cutolo

Dellafiore

et al. 2016

J Ultrasound

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Purpose To evaluate the inter-device reproducibility of retrobulbar blood flow measurements obtained by two commercially available CDI (color Doppler imaging) devices. Methods The right eyes of 10 healthy volunteers were investigated. Four examiners, namely two ophthalmologists and two radiologists, performed CDI examination of the ophthalmic artery, central retinal artery and temporal short posterior ciliary arteries using both CDI devices: ESAOTE MYLAB TM and SIEMENS ANTARES STEL-LAR PLUS TM . The peak systolic velocity (PSV), the enddiastolic velocity (EDV) and the resulting resistivity index (RI) were averaged for 3 cardiac cycles. To evaluate the reproducibility between both device measurements, the Lin's concordance correlation coefficient (CCC) was used. CCC can be expressed as the product of Pearson's r (the measure of precision) and C_b (the measure of accuracy). Results Results show that the inter-device reproducibility for CDI measurements is not acceptable since a poor degree of overall concordance (0.15\CCC\0.37) was obtained: accuracy was high (C_b [ 0.71) but overall precision low (0.18\Pearson's r\0.47). Ophthalmologists and radiologists obtained similar results. Conclusions To evaluate the causal role of blood flow abnormalities in glaucoma, CDI analysis using different devices seems unreliable. CDI inter-device reproducibility seems unrelated to medical speciality of the examiners. However, to improve present results, the use of similar probes and standardized CDI instrument settings as well as a CDI images analysis by a single grader, might possibly improve the inter-device reproducibility when testing the retrobulbar blood flow velocity.Keywords Blood flow velocity Á Doppler ultrasound imaging Á Glaucoma Á Healthy volunteers Á Reproducibility of results AbstractScopo Valutare la riproducibilità delle misurazioni delle velocità di flusso ematico nei vasi retrobulbari di volontari sani: le misurazioni sono state ottenute con due diverse strumentazioni ecografiche commercialmente disponibili. Materiali e Metodi Quattro operatori, due radiologi e due oculisti, hanno misurato le velocità di flusso nell'arteria oftalmica (AO), nell'arteria centrale della retina (ACR) e nelle arterie ciliari posteriori brevi (ACPB) in 10 occhi di volontari sani utilizzando due ecografi: ESAOTE MYLAB TM and SIEMENS ANTARES STELLAR PLUS TM . Sono state calcolate le medie di 3 cicli cardiaci dei parametri di flusso PSV (velocità di picco sistolico), EDV (velocità di fine diastole) e IR (indice di resistività). Per valutare la riproducibilità delle misure effettuate con le due strumentazioni è stato calcolato il coefficiente di correlazione di Lin (CCC). Il CCC può essere espresso come il prodotto del coefficiente di Pearson's r (misura della precisione) e C_b (misura dell'accuratezza). Risultati I risultati mostrano che la riproducibilità delle misurazioni tra due ecografi non è accettabile dal momento che è stato ottenuto uno scarso grado di concordanza (0.15\CCC\0.37): il grado di accuratezza è alto (C_b [ 0....

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“…Although it is an ultrasonographic procedure, reproducibility and repeatability of CDI is very high (Matthiessen et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Short-term effects of intravitreal bevacizumab (Avastin^®) on retrobulbar hemodynamics in patients with neovascular age-related macular degeneration

Toklu

Çakmak

Raza

et al. 2011

Acta Ophthalmologica

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ABSTRACT.Purpose: To evaluate the short-term effects of intravitreal bevacizumab on retrobulbar hemodynamics in patients with neovascular age-related macular degeneration (AMD). Methods: This study was carried out at Ataturk Training and Research Hospital 1st Ophthalmology Clinic, Ankara. Fourteen patients with neovascular AMD, who were treated with intravitreal injection of bevacizumab, were included in this study. Peak systolic velocity (PSV), end-diastolic velocity (EDV) and resistivity index (RI) were measured with colour Doppler imaging (CDI) in the ophthalmic artery, central retinal artery (CRA) and posterior ciliary artery. Results: The mean age of the 14 patients was 78 ± 9 (64-87). Of the 14 patients, eight were men and six were women. Colour Doppler imaging measurements of EDV (p = 0.015) and RI (p = 0.009) parameters of CRA revealed statistically significant difference among all three periods. End-diastolic velocity values decreased at the end of the 1st week and returned close to preoperative values at the end of the 1st month after the procedure. Also, EDV of posterior ciliary artery (PCA) decreased at the end of the 1st week and returned close to preoperative values at the end of the 1st month after the procedure. Resistivity index of PCA showed a temporary increase at the end of the 1st week and returned close to preoperative values at the end of the 1st month after the procedure. Conclusion: Injection of bevacizumab decreased blood velocities of CRA and PCA and increased RI of CRA and PCA in the early postoperative period and returned to preoperative values at the end of the first month.

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Reproducibility of blood flow velocity measurements using colour decoded Doppler imaging

Cited by 72 publications

References 20 publications

Volumetric colour Doppler imaging: a useful tool for the determination of ocular blood flow in glaucoma patients?

Volumetric colour Doppler imaging: a useful tool for the determination of ocular blood flow in glaucoma patients?

Inter-device reproducibility of retrobulbar blood flow velocity measurements in healthy subjects using color Doppler imaging

Short-term effects of intravitreal bevacizumab (Avastin^®) on retrobulbar hemodynamics in patients with neovascular age-related macular degeneration

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Reproducibility of blood flow velocity measurements using colour decoded Doppler imaging

Cited by 72 publications

References 20 publications

Volumetric colour Doppler imaging: a useful tool for the determination of ocular blood flow in glaucoma patients?

Volumetric colour Doppler imaging: a useful tool for the determination of ocular blood flow in glaucoma patients?

Inter-device reproducibility of retrobulbar blood flow velocity measurements in healthy subjects using color Doppler imaging

Short-term effects of intravitreal bevacizumab (Avastin®) on retrobulbar hemodynamics in patients with neovascular age-related macular degeneration

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Short-term effects of intravitreal bevacizumab (Avastin^®) on retrobulbar hemodynamics in patients with neovascular age-related macular degeneration