Purpose To evaluate the inter-device reproducibility of retrobulbar blood flow measurements obtained by two commercially available CDI (color Doppler imaging) devices. Methods The right eyes of 10 healthy volunteers were investigated. Four examiners, namely two ophthalmologists and two radiologists, performed CDI examination of the ophthalmic artery, central retinal artery and temporal short posterior ciliary arteries using both CDI devices: ESAOTE MYLAB TM and SIEMENS ANTARES STEL-LAR PLUS TM . The peak systolic velocity (PSV), the enddiastolic velocity (EDV) and the resulting resistivity index (RI) were averaged for 3 cardiac cycles. To evaluate the reproducibility between both device measurements, the Lin's concordance correlation coefficient (CCC) was used. CCC can be expressed as the product of Pearson's r (the measure of precision) and C_b (the measure of accuracy). Results Results show that the inter-device reproducibility for CDI measurements is not acceptable since a poor degree of overall concordance (0.15\CCC\0.37) was obtained: accuracy was high (C_b [ 0.71) but overall precision low (0.18\Pearson's r\0.47). Ophthalmologists and radiologists obtained similar results. Conclusions To evaluate the causal role of blood flow abnormalities in glaucoma, CDI analysis using different devices seems unreliable. CDI inter-device reproducibility seems unrelated to medical speciality of the examiners. However, to improve present results, the use of similar probes and standardized CDI instrument settings as well as a CDI images analysis by a single grader, might possibly improve the inter-device reproducibility when testing the retrobulbar blood flow velocity.Keywords Blood flow velocity Á Doppler ultrasound imaging Á Glaucoma Á Healthy volunteers Á Reproducibility of results AbstractScopo Valutare la riproducibilità delle misurazioni delle velocità di flusso ematico nei vasi retrobulbari di volontari sani: le misurazioni sono state ottenute con due diverse strumentazioni ecografiche commercialmente disponibili. Materiali e Metodi Quattro operatori, due radiologi e due oculisti, hanno misurato le velocità di flusso nell'arteria oftalmica (AO), nell'arteria centrale della retina (ACR) e nelle arterie ciliari posteriori brevi (ACPB) in 10 occhi di volontari sani utilizzando due ecografi: ESAOTE MYLAB TM and SIEMENS ANTARES STELLAR PLUS TM . Sono state calcolate le medie di 3 cicli cardiaci dei parametri di flusso PSV (velocità di picco sistolico), EDV (velocità di fine diastole) e IR (indice di resistività). Per valutare la riproducibilità delle misure effettuate con le due strumentazioni è stato calcolato il coefficiente di correlazione di Lin (CCC). Il CCC può essere espresso come il prodotto del coefficiente di Pearson's r (misura della precisione) e C_b (misura dell'accuratezza). Risultati I risultati mostrano che la riproducibilità delle misurazioni tra due ecografi non è accettabile dal momento che è stato ottenuto uno scarso grado di concordanza (0.15\CCC\0.37): il grado di accuratezza è alto (C_b [ 0....
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