Reprint

Broderick, Joseph P.; Connolly, Sander; Feldmann, Edward; Hanley, Daniel F.; Kase, Carlos S.; Krieger, Derk; Mayberg, Marc R.; Morgenstern, Lewis B.; Ogilvy, Christopher S.; Vespa, Paul; Zuccarello, Mario

doi:10.1161/circulationaha.107.183689

Cited by 312 publications

(77 citation statements)

References 208 publications

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“…Of the patients who survive, 80% will be unable to function independently at 6 months poststroke 2, 3. The initial tissue injury of ICH activates numerous secondary injury pathways, including the release of toxic hemolysis products, enhanced oxidative stress, and robust proinflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Soluble CD163 in intracerebral hemorrhage: biomarker for perihematomal edema

Roy-O’Reilly

Zhu

Atadja

et al. 2017

Ann Clin Transl Neurol

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ObjectivePatients with intracerebral hemorrhage (ICH) may elaborate varying degrees of perihematomal edema (PHE), requiring closer monitoring and a higher intensity of treatment. Here, we explore whether the soluble form of CD163, a scavenger receptor responsible for hemoglobin sequestration, can serve as a prognostic biomarker of PHE development and poor outcome after ICH.MethodsOur study cohort was comprised of 51 primary age‐ and sex‐matched ICH patients with moderate‐sized, hypertensive deep hemorrhages. Patients were part of a prospective ICH registry cataloguing admission data along with functional outcomes. We measured sCD163 levels in serial serum and cerebrospinal fluid (CSF) samples obtained at prespecified timepoints. Descriptive statistics, including a generalized estimating equation for longitudinal data, were used to analyze sCD163 in relation to ICH outcomes.ResultsAcute serum sCD163 (<48 h postictus) was significantly elevated in ICH patients compared to both acute neurological event controls (P = <0.001) and healthy controls (P = 0.003). As predicted, acute serum sCD163 levels were significantly associated with both hematoma volume expansion (P = 0.009) and PHE expansion (P = 0.002). Further examination determined that patients with high PHE expansion had poorer modified Rankin Scale scores at discharge (P = 0.024), and circulating sCD163 levels were found to be significantly lower in patients with high‐level PHE expansion.InterpretationAcute sCD163 levels may be a useful biomarker for the acute identification of patients at risk for hematoma expansion, perihematomal edema expansion and poorer short‐term outcomes.

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Section: Introductionmentioning

confidence: 99%

Soluble CD163 in intracerebral hemorrhage: biomarker for perihematomal edema

Roy-O’Reilly

Zhu

Atadja

et al. 2017

Ann Clin Transl Neurol

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“…Intracerebral hemorrhage (ICH) is one of the most devastating forms of stroke [1]. Observational studies have reported a modest but important risk of early seizure following ICH.…”

Section: Introductionmentioning

confidence: 99%

“…Observational studies have reported a modest but important risk of early seizure following ICH. [2,3] Due to this risk, consideration of prophylactic antiepileptic drug (AED) use is recommended for patients with lobar hemorrhage in current guidelines for management of ICH [1,4]. However, it is not clear that seizures worsen outcome from ICH and there is evidence that AEDs may impair recovery in patients with other types of brain injury.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic Antiepileptic Drug Use is Associated with Poor Outcome Following ICH

et al. 2009

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“…Guidelines for the management of spontaneous ICH were published in 1999 ( n = 15), 2007 ( n = 23), and 2010 ( n = 11), with the last one being the most-cited article annually [4, 15, 16]. It is notable that the most recent guidelines were cited more frequently, which can be attributed to physicians considering the evidence-based guidelines when treating patients nowadays.…”

Section: Discussionmentioning

confidence: 99%

Citation Classics in Stroke: The Top-100 Cited Articles on Hemorrhagic Stroke

et al. 2017

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Background: Stroke is a disastrous disease and a major health burden worldwide, especially in Korea. Hemorrhagic stroke (HS) accounts for approximately 20% of all the types of strokes. It is important to be able to evaluate stroke diagnoses and evolving treatments. Objective: We aimed to identify the top-100 cited articles and assess a paradigm shift that occurred in the field of HS. Methods: We searched all articles that had been cited more than 100 times using the Web of Science citation search tool during January 2016. Among a total of 2,651 articles, we identified the top-100 cited articles on HS. Results: The number of citations for the articles analyzed in this study ranged from 1,746 to 211, and the number of annual citations ranged from 125.6 to 5.5. Most of the articles that were published in Stroke (35%) and Journal of Neurosurgery (22%), originated in the United States (n = 56), were original articles (64%), and dealt with the natural history or etiology (n = 37) and vasospasm in subarachnoid hemorrhage (n = 8). Conclusions: We analyzed the top-100 cited articles in the field of HS based on citation rates. The results provide a unique perspective on historical and academic developments in this field.

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Reprint

Abstract: Purpose-The aim of this statement is to present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous intracerebral hemorrhage.

Cited by 312 publications

References 208 publications

Soluble CD163 in intracerebral hemorrhage: biomarker for perihematomal edema

Soluble CD163 in intracerebral hemorrhage: biomarker for perihematomal edema

Prophylactic Antiepileptic Drug Use is Associated with Poor Outcome Following ICH

Citation Classics in Stroke: The Top-100 Cited Articles on Hemorrhagic Stroke

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