Repression of melanoma tumor in vitro and in vivo by photothermal effect of carbon xerogel nanoparticles

Gorgizadeh, M.; Azarpira, Negar; Veis, R. Dehdari; Sattarahmady, N.

doi:10.1016/j.colsurfb.2019.01.032

Cited by 23 publications

(12 citation statements)

References 55 publications

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“…Nanoparticles have potential toxic to the liver, kidney, neurons, and cardiovascular system, which would limit their application in clinic. Therefore, using reduced nanoparticle quantities is preferable, and lowtoxicity or concentration particles should be utilized [63]. Herein, the MTT assay and FCM indicated that HRZ/siTGF-β1 nanoliposomes had low cytotoxicity and acted in a concentration-dependent manner in human macrophages.…”

Section: Tgf-β1 Silencing Analysismentioning

confidence: 94%

Preparation, Characterization, and in-vitro Cytotoxicity of Nanoliposomes Loaded With Anti-tuberculous Drugs and TGF-β1 Sirna for Improving Spinal Tuberculosis Therapy

Niu¹,

Z²,

Yang³

et al. 2020

Preprint

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Background: Tuberculosis (TB) represents a bacterial infection affecting many individuals each year and potentially leading to death. Overexpression of transforming growth factor (TGF)-β1 has a major immunomodulatory function in human tuberculosisThis work aimed to develop nanoliposomes to facilitate the delivery of antituberculous products to THP-1-derived human macrophages as Mycobacterium host cells, and to evaluate drug efficiencies as well as the effects of a TGF-β1-specific short interfering RNA (siRNA) delivery system employing nanoliposomes.Methods: siTGF-β1 nanoliposomes loaded with the anti-TB drugs HRZ (isoniazid, rifampicin and pyrazinamide) were prepared, and characterized in vitro, determining the size, zeta potential, morphology, drug encapsulation efficiency (EE), cytotoxicity, and gene silencing efficiency of TGF-β1 siRNA.Results: HRZ/siTGF-β1 nanoliposomes appeared as smooth spheres showing size and positive zeta potential of 168.135±0.5444 nm and +4.03±1.32 mV, respectively. Drug EEs were 90%, 88%, and 37% for INH, RIF, and PZA, respectively. Meanwhile, the nanoliposomes were weakly cytotoxic towards human macrophages as assessed by the MTT assay. Nanoliposomal siTGF-β1 could significantly downregulate TGF-β1 in THP-1-derived human macrophages in vitro.Conclusion: These ﬁndings suggested that HRZ-loaded nanoliposomes with siTGF-β1 have the potential for improving spinal tuberculosis chemotherapy via nano-encapsulation of anti-TB drugs.

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Section: Tgf-β1 Silencing Analysismentioning

confidence: 94%

Preparation, Characterization, and in-vitro Cytotoxicity of Nanoliposomes Loaded With Anti-tuberculous Drugs and TGF-β1 Sirna for Improving Spinal Tuberculosis Therapy

Niu¹,

Z²,

Yang³

et al. 2020

Preprint

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“…Despite the efforts described above, research on PM-induced skin carcinogenicity has produced fragmentary descriptions of the mechanisms involved compared with studies on the respiratory system. Almost all risk factors are based on the cancerous effects of the hazardous components of PM 2.5 , including black carbon and PAHs [ 59 , 60 ], or on the stimulation of cytotoxic signals that leads to carcinogenesis. Severe levels of ROS production and pro-inflammatory cytokine secretion are actively discussed as major promoters of skin cancer [ 61 , 62 ], and have been demonstrated to occur upon PM exposure in other experimental studies.…”

Section: The Adverse Effects Of Pm On Skinmentioning

confidence: 99%

Genomic Approach to the Assessment of Adverse Effects of Particulate Matters on Skin Cancer and Other Disorders and Underlying Molecular Mechanisms

et al. 2021

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Air pollutants are in the spotlight because the human body can easily be exposed to them. Among air pollutants, the particulate matter (PM) represents one of the most serious toxicants that can enter the human body through various exposure routes. PMs have various adverse effects and classified as severe carcinogen by International Agency for Research on Cancer. Their physical and chemical characteristics are distinguished by their size. In this review, we summarized the published information on the physicochemical characteristics and adverse effects of PMs on the skin, including carcinogenicity. Through comparisons of biological networks constructed from relationships discussed in the previous scientific publications, we show it is possible to predict skin cancers and other disorders from particle-size-specific signaling alterations of PM-responsive genes. Our review not only helps to grasp the biological association between ambient PMs and skin diseases including cancer, but also provides new approaches to interpret chemical-gene-disease associations regarding the adverse effects of these heterogeneous particles.

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“…After the intravenous injection of functionalized multiwalled CNTs (Polyethylene glycol-coated oxidized carbon nanotubes), the photothermal destruction of melanoma cells was highly enhanced, in contrast to the laser-mediated photothermal ablation alone [72]. Gorgizadeh M. et al (2019) used carbon xerogel nanoparticles as a photoabsorber of 808 nm laser light in vitro and in vivo in a melanoma tumor-bearing mouse model with good biocompatibility and tumor control [75].…”

Section: Photothermal Therapymentioning

confidence: 99%

Nanosystems for Improved Targeted Therapies in Melanoma

Beiu

Giurcăneanu

Grumezescu

et al. 2020

JCM

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Melanoma is one of the most aggressive forms of skin cancer, with limited therapeutic options. Since its incidence has been rapidly rising in recent years, the study of new targeted therapeutic strategies has increased. The implication of nanoscience in the development of alternative targeted therapies for melanoma has multiple benefits and could significantly improve the outcome of melanoma patients. In this paper, we review the most recent progress in the field of targeted therapies, emphasizing the impact of nanoscale materials on the targeting and controlled release of anti-tumor drugs. The applications of nanomedicine in the management of melanoma are extensive and refer to sentinel lymph node mapping, chemotherapy, and RNA interference; each of these applications harboring the potential to develop efficient and personalized diagnostic techniques and therapies. Further research, especially in clinical trials, is needed to establish whether fighting melanoma on the nanoscale level represents the key to reaching a critical inflection point in mankind’s battle with metastatic melanoma.

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Repression of melanoma tumor in vitro and in vivo by photothermal effect of carbon xerogel nanoparticles

Cited by 23 publications

References 55 publications

Preparation, Characterization, and in-vitro Cytotoxicity of Nanoliposomes Loaded With Anti-tuberculous Drugs and TGF-β1 Sirna for Improving Spinal Tuberculosis Therapy

Preparation, Characterization, and in-vitro Cytotoxicity of Nanoliposomes Loaded With Anti-tuberculous Drugs and TGF-β1 Sirna for Improving Spinal Tuberculosis Therapy

Genomic Approach to the Assessment of Adverse Effects of Particulate Matters on Skin Cancer and Other Disorders and Underlying Molecular Mechanisms

Nanosystems for Improved Targeted Therapies in Melanoma

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