Objetive: discuss the importance of multidisciplinary care for patients undergoing Hematopoietic Stem Cell Transplantation (HSCT) based on the transdisciplinary care. Method: This is a theoretical essay discussing. Results: Each year, about 50 million people are undergoing HSCT worldwide. This therapeutic strategy is used for some oncological, hematological or immunological, malignant and non-malignant inherited or acquired diseases. during the steps after HSCT, patients, and their families experience moments of anxiety, anguish and uncertainty that cause stress and interfere with their daily lives. The multidisciplinary team working in HSCT service provide complex and specialized care since this scenario requires specific knowledge of the area. However, they do not relieve the interweaving of new knowledge for an interdisciplinary practice that meets the patient´s health needs in this delicate moment of his life. From this perspective, health professionals of HSCT service should excel by constantly learning and dynamic interventions and sharing of knowledge in the multidisciplinary team that includes a complex and transdisciplinary care. Conclusion: This essay causes the discussion about care in HSCT based on transdisciplinary care. It should be emphasized the responsibility of each member of the multidisciplinary team for the contribution and strengthening of the patient´s quality of life. In a way, the interdisciplinary care permeates the complexity in an open perspective of approximation of the various areas of knowledge.