Repositioning of molsidomine for its efficacy in diabetes induced erectile dysfunction in rats: In silico, in vitro and in vivo approach

Diabetes mellitus (DM) prevalence is increasing at an alarming rate as it was 381 million people globally in 2013 and is estimated to be 463 million people in 2019 rising to 578 million by 2030. It is a disease with high rate of complications such as neuropathy, nephropathy, retinopathy, erectile dysfunction etc. 1,2 Diabetic neuropathy is a family of disorders that damage the different regions of the nervous system, either individually or in combination. It affects pain fibres, motor neurons and autonomic nervous system. 3 It results in large economic costs for its care. [4][5][6] The various kind of neuropathies include peripheral neuropathy, proximal neuropathy, autonomic neuropathy and focal neuropathy. 7 There are a number of reasons for the pathogenesis of diabetic neuropathy and polyol pathway of glucose metabolism is thought as one of the major mechanism. 8 Peripheral neuropathy is a type of nerve damage that usually affects feet and legs and sometimes hands and arms. 9 It is proved that reactive oxygen species (ROS) plays a significant role in the pathophysiology of neuropathic pain in diabetes. 10 Out of all diabetic patients, 50% of patients develop neuropathy and painful neuropathy ranges from 10% to 20% in patients with diabetes. Diabetic patients can experience nerve problems at any time and the problem increases with age, weight and duration. 5 The complications across various countries varies from 10% to 30% and it is higher in developed countries than in developing countries. These complications can lead to painful symptoms and can affect quality of life of the patient. The treatment for the painful diabetic

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Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

Nayak

Minaz

Pasha

2021

Anim Models and Exp Med

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Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis

Mohamed

Suddеk

El‐Kashef

2021

International Immunopharmacology

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Overview of the effects and mechanisms of NO and its donors on biofilms

Tian,

et al. 2023

Critical Reviews in Food Science and Nutrition

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Repositioning of molsidomine for its efficacy in diabetes induced erectile dysfunction in rats: In silico, in vitro and in vivo approach

Abstract: The results highlight the rationale behind the repositioning of molsidomine therapy for the management of diabetic erectile dysfunction.

Cited by 4 publications

References 23 publications

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis

Overview of the effects and mechanisms of NO and its donors on biofilms

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