Reporting Standards in Clinical Studies Evaluating Bone Marrow Aspirate Concentrate: A Systematic Review

Murray, Iain R.; Robinson, Patrick G; West, Christopher C.; Goudie, Ewan B.; Yong, Li; White, T O; LaPrade, Robert F.

doi:10.1016/j.arthro.2017.11.036

Cited by 45 publications

(43 citation statements)

References 55 publications

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“…Explicitly, it is important to understand that the BMC non-stem cell cellular components in the treatment vial might have significant roles regarding behavior and function of MSCs. Recently, the cellular variances were confirmed in a systematic review, evaluating BMC studies in musculoskeletal pathologies [53]. Presumably, as postulated by numerous authors, the variances in BMC cellular compositions have a significant effect on the biological activity and regenerative potency of the treatment specimen, and these inconsistencies impact clinical outcomes [111,113].…”

Section: Not Every Bone Marrow Concentrate Is Born Equalmentioning

confidence: 85%

“…BM is relatively easy to harvest, largely available, and dispensable. Obviously, it is important that the BMA procedure is performed impeccably to obtain an optimal quality of viable BM tissue [5,53]. In humans, the most common anatomical location to obtain BM is the iliac crest, but other BMA sites have been utilized ( Table 2).…”

Section: Bone Marrow Aspiration Anatomical Sitesmentioning

confidence: 99%

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The Rationale of Autologously Prepared Bone Marrow Aspirate Concentrate for use in Regenerative Medicine Applications

Everts¹,

Flanagan²,

Rothenberg³

et al. 2020

Regenerative Medicine

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Autologously prepared bone marrow aspirate concentrates, have the potential to play an adjunctive role in various patient pathologies that have not been able to heal with conventional treatment modalities. The use of bone marrow aspirate (BMA) and concentrates in regenerative medicine treatment plans and clinical applications is based on the fact that bone marrow cells, including progenitor and nucleated cells, platelets, and other cytokines, support in tissue healing and tissue regenerative processes. The use of concentrated BMA cells focuses primarily on mesenchymal stem cells (MSCs), with the ability to self-renew and differentiate into multiple cell types. Concentrated bone marrow cells can be retrieved from harvested BMA and ensuing minimal manipulative cell processing techniques, executed at point of care (POC). The application of bone marrow biological therapies may offer solutions in musculoskeletal pathologies, spinal disorders, chronic wound care, and critical limb ischemia (CLI), to effectively change the local microenvironment to support in tissue healing and facilitate tissue regeneration. This chapter will address the cellular content of bone marrow tissue, harvesting and preparation techniques, and discuss the biological characteristics of individual marrow cells, their inter-connectivity, and deliberate on the effects of BMA concentration.

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Section: Not Every Bone Marrow Concentrate Is Born Equalmentioning

confidence: 85%

Section: Bone Marrow Aspiration Anatomical Sitesmentioning

confidence: 99%

The Rationale of Autologously Prepared Bone Marrow Aspirate Concentrate for use in Regenerative Medicine Applications

Everts¹,

Flanagan²,

Rothenberg³

et al. 2020

Regenerative Medicine

View full text Add to dashboard Cite

show abstract

“…Thus, the concentrated product contains MSCs, hematopoietic stem cells, platelets, and cytokines, including plateletderived growth factor, transforming growth factor-b, interleukin (IL)-1 receptor antagonist, and bone morphogenetic proteins 2 and 7 [90][91][92][93][94]. However, given the variable concentrations of these substances based on the source of the aspiration and the processing protocols, there is variability in the final compositions [95]. After PRP treatment, patients with patellar tendinopathy showed statistically significant improvement.…”

Section: Bone Marrow Aspirate Concentratementioning

confidence: 99%

Regenerative Sports Medicine: Past, Present, and Future (Adapted From the PASSOR Legacy Award Presentation; AAPMR; October 2016)

Borg‐Stein

Osoria

Hayano

2018

PM&R

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Regenerative medicine has shown dramatic expanse and evolution in the past decade. Within that milieu, physiatrists are taking an active role in research, clinical care delivery, and education. The purpose of this review is to provide a balance among evidence, theory, experience, clinical trends, and the foreseeable future. We focus on the literature that reports the research with the best methodology in each practice area, recognizing that the level of evidence varies substantially among different treatment modalities and conditions. The following elements are included: an overview of the evolution of currently available regenerative techniques, evidence base for each available modality (prolotherapy, platelet rich plasma, bone marrow aspirate concentrate and stem cells, adipose-derived stem cells, and amniotic tissue products), general principles in the application of these treatments, and discussion and a vision of what lies ahead. We expect that practitioners will use this review to facilitate clinical decision making and to provide a core knowledge base to assist when counseling patients. LEVEL OF EVIDENCE: IV.

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“…The number of studies that are performed in the field is increasing in an exponential scale, and the fact that more than 700 clinical trials are currently registered for bone marrow aspirate concentrates (BMAC) is indicative of the predominant role that they will play in future orthopaedic applications. 1 Because these therapeutic approaches have become popular and part of our everyday orthopaedic practice, it is important to note the great amount of variability among the different BMAC preparations and to establish the characteristics that are necessary to report. 2 This becomes more critical as randomized controlled trials and systematic reviews that demonstrate some potential benefits from their use are rapidly emerging.…”

Section: See Related Article On Page 1366mentioning

confidence: 99%

Editorial Commentary: Not All Bone Marrow Aspirate Concentrates Are the Same: The Necessity of Detailed Reporting and Other Lessons Learned From Cell-based Treatments in Orthopaedics

Paschos¹

2018

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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Bone marrow aspirate concentrates have become a popular therapeutic approach for several musculoskeletal conditions. A plethora of different preparations exist that make difficult to evaluate their clinical outcome and, thus, to make safe conclusions for their effectiveness. The first step for this assessment is comprehensive and reliable reporting of all the important variables that would allow characterization of their content and properties. This is critical for the understanding of their mechanism of action and the identification of the proper indications based on patient and disorder characteristics that could potentially lead to their effective application in clinical scenarios.

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Reporting Standards in Clinical Studies Evaluating Bone Marrow Aspirate Concentrate: A Systematic Review

Cited by 45 publications

References 55 publications

The Rationale of Autologously Prepared Bone Marrow Aspirate Concentrate for use in Regenerative Medicine Applications

The Rationale of Autologously Prepared Bone Marrow Aspirate Concentrate for use in Regenerative Medicine Applications

Regenerative Sports Medicine: Past, Present, and Future (Adapted From the PASSOR Legacy Award Presentation; AAPMR; October 2016)

Editorial Commentary: Not All Bone Marrow Aspirate Concentrates Are the Same: The Necessity of Detailed Reporting and Other Lessons Learned From Cell-based Treatments in Orthopaedics

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