Report on the incidence of squamous cell carcinomas affecting the eyelids in England over a 15-year period (2000–2014)

Wawrzynski, James; Tudge, Isobel; Fitzgerald, Eleanor; Collin, Richard; Desai, Parul; Emeriewen, Krisztina; Saleh, George M.

doi:10.1136/bjophthalmol-2017-310956

Cited by 23 publications

(28 citation statements)

References 17 publications

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“…In both men and women the development of BCC and more particularly SCC was associated with increased age, in keeping with previous reports from cancer registries in England [20,21]. This differential age profile may be due to the aetiology of the keratinocyte carcinomas, whereby cumulative UV exposure, and also immunosuppression are implicated in SCC, whereas development of BCC is related to intermittent high-dose sun exposure [22].…”

Section: Discussionsupporting

confidence: 86%

“…Eyelid SCC was more common in men, in all age groups, with an overall relative risk of 1.5. This finding has been reported in other populations, though with a greater sex association, including a relative risk for men compared to women of 1.9 in England [21], and 2.0 in Australia [6], for eyelid SCC.…”

Section: Discussionsupporting

confidence: 83%

“…In comparison, there was an increase in rate of eyelid SCC in women by a mean rate of 3% annually, though no change in men. An increase in skin SCC in other Caucasian populations has been described, in Northern Ireland, England, Canada, the Netherlands, and Australia [21,[27][28][29][30]. There are a variety of possible contributing factors to our finding of increasing SCC in womenincreased awareness and surveillance for skin cancer, with subsequent increased detection may be relevant.…”

Section: Discussionmentioning

confidence: 92%

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National incidence of eyelid cancer in Ireland (2005–2015)

Quigley

Deady

Hughes

et al. 2019

Eye

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Aims We report on the incidence of cutaneous eyelid tumours in Ireland over the 11-year-period from 2005 to 2015, we identify associations between demographic factors and cutaneous eyelid tumour risk. Methods Skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), melanoma, and other cancers, located on the eyelid or canthus according to ICD-10 coding, as registered by the National Cancer Registry of Ireland (NCRI), were captured from the period 2005 to 2015. Age standardised rates (ASR) were calculated according to the European Standard Population (2013). Longitudinal data analysis using linear regression, and associations with age and sex were evaluated with the statistics program R. Results There were 4824 patients diagnosed with eyelid BCC during the study period, the ASR in men and women was mean 15.87 and 13.49 per 100,00, respectively. The relative risk for eyelid BCC in men compared with women was 1.18, age was associated with incidence. There were 528 patients diagnosed with SCC; the ASR of eyelid SCC in men and women was 2.10 and 1.39 per 100,000, respectively, and increased in women annually (β = 0.07, p = 0.0005). The relative risk for eyelid SCC in men compared with women was 1.51, and age was exponentially associated with SCC. Melanoma and other eyelid tumours were uncommon-50 and 55 cases, respectively. Conclusion Incidence of both BCC and SCC increases with age and male sex. The incidence of eyelid SCC is increasing in women, and under age 50, eyelid BCC is more common in women than men. Synopsis We describe the recent incidence of eyelid cancers in Ireland, from National Cancer Registry Data. We find eyelid BCC, and also SCC, are associated with increased age. Rate of eyelid SCC is increasing in women.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 92%

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National incidence of eyelid cancer in Ireland (2005–2015)

Quigley

Deady

Hughes

et al. 2019

Eye

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“…Eyelid SCC is a disease of the elderly, with a mean age at presentation of 60 years, and has a male predilection [47]. However, in our study, the mean age at presentation of SCC was 55 years and the disease had a slight female preponderance with a male:female ratio of 1: 1.1.…”

Section: Discussioncontrasting

confidence: 49%

Malignant Eyelid Tumors in India: A Study of 536 Asian Indian Patients

et al. 2018

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Purpose: To study the proportion of eyelid malignant tumors in an Asian Indian population and to review their clinical features and outcomes. Methods: This is a retrospective study of 536 patients. Results: The mean age at presentation with eyelid malignancy was 58 years. Histopathology-proven diagnoses of these patients included sebaceous gland carcinoma (SGC) (n = 285, 53%), basal cell carcinoma (BCC) (n = 128, 24%), squamous cell carcinoma (SCC) (n = 99, 18%), and miscellaneous tumors (n = 24, 4%). The statistically significant differences between eyelid malignant tumors included age at presentation, tumor location, and tumor extent. The clinicopathological correlation of SGC, BCC, SCC, and miscellaneous tumors was 91, 86, 46, and 38% (p = 0.001), respectively. Comparing SGC with BCC, SCC, and miscellaneous tumors, SGC was more commonly associated with tumor recurrence (21 vs. 3, 8, and 13%; p = 0.001), systemic metastasis (13 vs. 0, 4, and 13%; p = 0.001), and death (9 vs. 0, 4, and 0%; p = 0.004). Compared to SGC, BCC, and SCC, locoregional lymph node metastasis was more common with miscellaneous tumors (26 vs. 16, < 1, and 8%; p = 0.001) over a mean follow-up period of 19 months. Conclusion: In Asian Indians, SGC is twice as common as BCC and 3 times more common than SCC. SGC is associated with poorer prognosis compared to other eyelid malignant tumors.

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“…Using the English registry, Wawrzynski et al [7] found that over a 15-year period (2000–2014), there was an increase in the age-standardized rate of eyelid SCC from 0.55 per 100,000 people in the period between 2000 and 2002 to 0.69 per 100,000 people in the period between 2012 and 2014, an increase of approximately 2% per year. The mean age-standardized incidence rate of SCC during the study period was 0.63 cases per 100,000 population per year.…”

mentioning

confidence: 99%