Report of Two Cases of Ciliary Body Mesectodermal Leiomyoma

Odashiro, Alexandre Nakao; Fernandes, Bruno F.; Al-Kandari, Abdullah; Gregoire, F.J.; Burnier, Miguel N.

doi:10.1016/j.ophtha.2006.07.023

Cited by 20 publications

(18 citation statements)

References 12 publications

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“…The demonstration of negative results for HMB-45 and S-100 confidently ruled out a melanoma. Similar to other reported cases, expressions of desmin, SMA, and caldesmon were suggestive of a leiomyoma in our patient [3,9,10]. There seems to be no difference between mesodermal and mesectodermal leiomyomas regarding clinical presentation, imaging characteristics, and prognosis.…”

Section: Discussionsupporting

confidence: 89%

“…All previous reports had the main purpose of demonstrating convincingly certain distinguishing histopathological and immunohistochemical features of mesectodermal leiomyoma in patients who were treated with enucleation or tumor resection [1,4,5,6,7,9,10]. We were unable to find a patient with mesectodermal leiomyoma in the literature treated with radiotherapy.…”

Section: Discussionmentioning

confidence: 81%

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Ciliary Body Mesectodermal Leiomyoma Diagnosed by Fine Needle Aspiration Biopsy

2017

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Aims: To describe the clinical, imaging, cytopathological, and immunohistochemical features of mesectodermal leiomyoma of the ciliary body diagnosed by fine needle aspiration biopsy in a patient who denied any major intervention without prior pathological verification. Methods: The clinical, imaging, and cytopathological records of the patient were retrospectively reviewed. A fine needle aspiration biopsy with a 25-G needle was performed after tailoring a scleral flap. Results: Examination of the cell blocks prepared from the aspirate demonstrated cells with granular cytoplasms and large nuclei. Immunohistochemical studies showed positive smooth muscle actin, desmin, h-caldesmon, CD56, and neuron-specific enolase stainings, suggesting both neurogenic and myogenic differentiation. Reactions for HMB-45, S-100, panCK, epithelial membrane antigen, glial fibrillary acidic protein, and CD68 were negative. Because the tumor continued to enlarge, fractionated stereotactic radiotherapy at the dose of 3,000 cGy was delivered, which reduced the size of the mass by 40% in 5 years. Conclusions: This case demonstrated that the diagnosis of mesectodermal leiomyoma of the ciliary body can be established with fine needle aspiration biopsy and that stereotactic radiotherapy can be successfully used to induce tumor regression.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 81%

Ciliary Body Mesectodermal Leiomyoma Diagnosed by Fine Needle Aspiration Biopsy

2017

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“…Some mesectodermal leiomyomas can be S-100 positive, a marker typically associated with melanoma, so this marker should not be used in isolation for diagnosis. Recently, CD56 has been used to confirm the neurogenic characteristics of mesectodermal leiomyoma [3,5], but this stain adds little to the diagnosis especially when the morphology is convincingly neuroid. By definition, mesectodermal leiomyoma has minimal mitotic activity, which contrasts with leiomyosarcoma characterized by significant mitotic activity seen both on light microscopy and staining for cellular proliferation [12].…”

Section: Discussionmentioning

confidence: 99%

“…Of note, “mesodermal” leiomyomas of the ciliary body, the broader category of tumor within which mesectodermal leiomyoma is a subset, has the same immunohistochemical profile but with more myogenic morphology on light microscopy [3]. For the purposes of clinical characterization, prognostication, and treatment planning, mesectodermal leiomyoma is equivalent to the mesodermal leiomyoma.…”

Section: Discussionmentioning

confidence: 99%

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Acute Presentation of Mesectodermal Leiomyoma of the Ciliary Body

Kim¹,

Hall²,

Elia³

et al. 2017

Ocul Oncol Pathol

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Purpose: We report a case of acutely presenting mesectodermal leiomyoma of the ciliary body in a 29-year-old female who reported waking up with swollen eyelids of the right eye and light-perception vision. The affected eye had elevated intraocular pressure, a flat anterior chamber, and a pale, round mass arising from the nasal ciliary body, invading the angle and protruding into the visual axis posterior to the lens. Within days, the visual acuity decreased to no light perception. The eye was enucleated. Methods: The enucleated eye harbored a tumor arising from the ciliary body, measuring 18 mm in the greatest dimension. Spindled cells with fibrillary cytoplasmic processes suggested a neural origin though negative for S-100, Melan-A, and HMB-45. The cells stained strongly positive for smooth muscle actin and vimentin, leading to the diagnosis of mesectodermal leiomyoma of the ciliary body. Results: We review the literature to expand upon the clinical findings, diagnostic methods, and histopathologic and immunohistochemistry characteristics of mesectodermal leiomyoma. Conclusion: Leiomyoma must be in the differential diagnosis for ciliary body mass, especially in women of reproductive age. Diagnosis relies on histopathology and immunohistochemistry. The mechanism of acute symptom onset may be multifactorial. This case emphasizes the possibility of acute presentation of a rare, benign intraocular tumor.

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Mesectodermal Suprauveal Iridociliary Leiomyoma: Transscleral Excision Without Postoperative Iris Defect

Razzaq¹

2011

Arch Ophthalmol

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Report of Two Cases of Ciliary Body Mesectodermal Leiomyoma

Cited by 20 publications

References 12 publications

Ciliary Body Mesectodermal Leiomyoma Diagnosed by Fine Needle Aspiration Biopsy

Ciliary Body Mesectodermal Leiomyoma Diagnosed by Fine Needle Aspiration Biopsy

Acute Presentation of Mesectodermal Leiomyoma of the Ciliary Body

Mesectodermal Suprauveal Iridociliary Leiomyoma: Transscleral Excision Without Postoperative Iris Defect

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