Report of the committee on the genetic constitution of chromosomes 10, 11, and 12

Ps, Gerald; Oj, Miller

doi:10.1159/000131695

Cited by 15 publications

(10 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and HRASI to 11 p 15, as confirmed in this report by in situ hybridization. In support of this INS, HRASI, and HBB assignment to 11 p 15 are several reports (Gusella et al, 1979;Huerrc et al, 1983;Martinvillc and Francke, 1983;Donlon et al, 1984;Gerald and Grzeschik, 1984); however, there have been mapping reports that differ and which are sometimes difficult to reconcile. In a previous ab stract.…”

Section: Discussionmentioning

confidence: 63%

“…Earlier studies (Gusella et al 1979), including an in situ hybridization analysis (Malcolm et al, 1981). had mapped HBB at 11 p i2 or near the centromere on lip, whereas more recent evidence argues for a location at 11 p 15 (Gerald and Grzeschik, 1984;Morton et al, 1984). INS, HBB, and HRASI were found to reside outside the area of deletions in aniridia-Wilms' tumor association (Huerre et al, 1983, suggesting a location at 11 p 15. but one in situ hybridization study on human pachytene chromosomes located HRASI at 11 p 14.1 (Jhanwaretal, 1983).…”

mentioning

confidence: 99%

“…1984Antonarakis et al, 1983; 1984a; White et al, 1984). The gene linkage studies generating linear order and genetic distances between these genes on 1 lp place INS or HRASI as the most distal genes and PTH as the most proximal gene, some 20 cM apart, but only for INS does the chromosomal localization seem to be established at 11 p 15 Donlon et al 1984;Gerald and Grzeschik, 1984). The positions of HBB and HRASI are still being resolved.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Chromosome mapping of genes on the short arm of human chromosome 11: parathyroid hormone gene is at 11p15 together with the genes for insulin, c-Harvey-<i>ras</i> 1, and β-hemoglobin

Zabel

Kronenberg

Bell³

et al. 1985

Cytogenet Genome Res

View full text Add to dashboard Cite

The human parathyroid hormone gene (PTH) was mapped to the 11p15 chromosomal band by in situ hybridization. Using the same procedures and cells, the closely linked β-hemoglobin gene (HBB), the Harvey-ras 1 proto-oncogene (HRASl), and the insulin gene (INS) were also mapped to this same region. Some reports have demonstrated differences in regional localization of the latter three genes, and linkage and molecular studies have not resolved how far this linkage group extends from p15 toward the centromere on the physical gene map. Our results show that all of these genes are localized at llpl5, a region of one chromosomal band that appears to comprise a genetic distance of more than 20 cM.

show abstract

Section: Discussionmentioning

confidence: 63%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Chromosome mapping of genes on the short arm of human chromosome 11: parathyroid hormone gene is at 11p15 together with the genes for insulin, c-Harvey-<i>ras</i> 1, and β-hemoglobin

Zabel

Kronenberg

Bell³

et al. 1985

Cytogenet Genome Res

View full text Add to dashboard Cite

show abstract

“…Genes for several other enzymes and nonenzymatic proteins have been assigned to 11 (Gerald and Miller, 1982). Acid phosphatase-2, catalase, LDHA, hemoglobin epsilon, gamma, delta, and beta chains, and the structural gene for insulin have been assigned by somatic cell hybridization and/or recom binant DNA techniques to the short arm of 11.…”

Section: Discussionmentioning

confidence: 99%

Assignment of the gene for neutral alpha-glucosidase AB to chromosome 11

Martiniuk

Smith

Ellenbogen

et al. 1983

Cytogenet Genome Res

View full text Add to dashboard Cite

Human tissues contain two isozymes of neutral a-glucosidase, neutral a-glucosidase AB and neutral a-glucosidase C (a-D-glucoside glucohydrolase, EC 3.2.1.20). The two isozymes, initially defined on the basis of differences in electrophoretic mobility in starch gel, have also been shown to have other distinguishing biochemical characteristics including different substrate specificites. Rodent tissues contain apparently homologous isozymes of neutral a-glucosidase. The mouse and human a-glucosidase C isozymes, but not the AB isozyme(s), can be distinguished by the difference in their electrophoretic mobility. This difference has previously enabled us to use human-mouse somatic cell hybrids to assign the structural gene for human a-glucosidase C to chromosome 15. We now report the differentiation of mouse and human neutral a-glucosidase AB isozymes by rocket immunoelectrophoresis, using an antibody raised in mice against purified human placental neutral a-glucosidase AB. This antibody precipitated both the A and B bands of human neutral a-glucosidase AB and did not cross react with mouse enzyme as determined by Ouchterlony double immunodiffusion and by rocket immunoelectrophoresis. Using this antibody, the segregation of human neutral a-glucosidase AB was examined in 41 mouse x human hybrid clones. Thirty-eight hybrid clones, derived from fusions of RAG x seven different human cells, showed 100% concordant segregation of human neutral a-glucosidase AB and the 11. Three additional clones, derived from a fusion of tetraploid murine erythroleukemia cells (2S-MEL) x diploid human fibroblasts carrying a translocation chromosome(s) allowed the regional localization of the gene to the long arm of 11 (11q13→11qter).

show abstract

“…The report of the previous meeting (Gerald and Miller, 1982) localized a glutathione-S-transferase to chromosome 11 and identified the transferase as GST1. This transferase is now said to be GST3 (van Cong et al, 1984).…”

Section: Chromosome 11 (Tables II Iii and Figs 2 3 4)mentioning

confidence: 99%