Report of a Toxic Manifestation Due to "Dinitrenal"

Hirsch, Sidney

doi:10.1001/jama.1934.02750120062030

Cited by 6 publications

(1 citation statement)

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“…This rash can be maculo-papular, urticarial, angiooedematous or a severe exfoliative dermatitis [39][40][41]. There is often accompanying pruritis and subsequent desquamation [39,41,42]. Prolonged peripheral neuritis has been reported, often affecting the hands and feet and associated with skin changes [11,43,44].…”

Section: Organ Systems Affected By Therapeutic Usementioning

confidence: 99%

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

2011

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2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects. DNP is sold mostly over the internet under a number of different names as a weight loss/slimming aid. It causes uncoupling of oxidative phosphorylation; the classic symptom complex associated with toxicity of phenol-based products such as DNP is a combination of hyperthermia, tachycardia, diaphoresis and tachypnoea, eventually leading to death. Fatalities related to exposure to DNP have been reported since the turn of the twentieth century. To date, there have been 62 published deaths in the medical literature attributed to DNP. In this review, we will describe the pattern and pathophysiology of DNP toxicity and summarise the previous fatalities associated with exposure to DNP.

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