Functional Changes in Liver, Heart and Muscles, and Loss of Dextrose Tolerance

MacBRYDE, Cyril M.

doi:10.1001/jama.1935.02760270015006

Cited by 19 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DNP effectively reduced the weight of obese individuals but caused notable dysfunctions in the heart, liver, and other organs due to the accumulation of DNP in these organs. [45] According to our results, MN-TADNP treatment decreased DNP accumulation in the heart, liver, kidney, spleen, and lung to a minimal level, while there was relatively high organ accumulation of DNP for O-DNP-and O-TADNP-treated groups (Figure 3I-K; Figure S7, Supporting Information). Notably, the DNP content in heart tissue in the MN-TADNP-treated group was the lowest compared with oral DNP or TADNP treatment, suggesting that MN-TADNP treatment most effectively prevented the accumulation of DNP in the heart tissue, which is favorable for alleviating the cardiotoxicity of DNP.…”

Section: In Vivo Biodistribution Of Dnp After Oral and Microneedle De...supporting

confidence: 53%

Non‐Cardiotoxic Tetradecanoic Acid‐2,4‐Dinitrophenol Ester Nanomicelles in Microneedles Exert Potent Anti‐Obesity Effect by Regulating Adipocyte Browning and Lipogenesis

Liang

Bao

et al. 2023

Small

View full text Add to dashboard Cite

Sustained oral uncoupler 2,4‐dinitrophenol (DNP) administration exerts prominent anti‐obesity effects, but the adipose tissue off‐target disadvantage leads to systemic adverse effects. A novel non‐cardiotoxicity DNP delivery method using a biocompatible microneedles patch containing the amphiphilic tetradecanoic acid‐DNP ester (TADNP) is described, which is synthesized via esterification on the phenolic hydroxyl of DNP. The TADNP is self‐assembled as nanomicelles, which enhance the endocytosis rate of DNP by adipocytes and its permeation in isolated adipose tissues. The microenvironment of adipose tissues promotes the massive release of DNP and plasma and simulated gastrointestinal fluids. The microneedles‐delivered TADNP nanomicelles (MN‐TADNP) effectively deliver DNP in treated adipose tissues and reduce DNP content in off‐target organs. Both oral and MN patch‐delivered TADNP micelles effectively exert anti‐obesity effects in a mouse model of high‐fat diet‐induced obesity; and noteworthily, MN‐TADNP exhibit more satisfactory biosafety than oral administration. Here, a smart MN patch loaded with tetradecanoic acid‐modified DNP is reported, which enhances its accumulation in adipose tissues and exerts an anti‐obesity effect without causing any systemic toxicity.

show abstract

Section: In Vivo Biodistribution Of Dnp After Oral and Microneedle De...supporting

confidence: 53%

Non‐Cardiotoxic Tetradecanoic Acid‐2,4‐Dinitrophenol Ester Nanomicelles in Microneedles Exert Potent Anti‐Obesity Effect by Regulating Adipocyte Browning and Lipogenesis

Liang

Bao

et al. 2023

Small

View full text Add to dashboard Cite

show abstract

“…In the 1930s, DNP was used clinically in humans as a treatment for obesity. However, its use was subsequently discontinued due to the occurrence of numerous deleterious side-effects at relatively high dosages (3-5 mg/kg body weight) (41,42). Such doses are ca.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Alzheimer's disease β‐amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy

et al. 2001

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a major public health problem, and there is currently no clinically accepted treatment to cure it or to stop its progression. Fibrillar aggregates of the β–amyloid peptide (Aβ) are major constituents of the senile plaques found in the brains of AD patients and have been related to AD neurotoxicity. Here it is shown that nitrophenols prevent aggregation and cause disaggregation of Aβ fibrils and that they strongly prevent the neurotoxicity of Aβ to rat hippocampal neurons in culture. Furthermore, by using an in vivo model system of cerebral amyloid deposition, it is shown that nitrophenols cause a marked reduction in the volume occupied by amyloid deposits in the hippocampi of rats. These results raise the possibility that nitrophenols or their derivatives may be useful lead compounds for the development of drugs to prevent the neurotoxicity and deposition of Aβ in AD.

show abstract

“…T wave and ST segment abnormalities have been noted and some of the earlier autopsied case reports recorded heart muscle damage [46,50,53]. Gastroenteritis and anorexia have been reported in high doses [11,36].…”

Section: Organ Systems Affected By Therapeutic Usementioning

confidence: 98%

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

2011

View full text Add to dashboard Cite

2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects. DNP is sold mostly over the internet under a number of different names as a weight loss/slimming aid. It causes uncoupling of oxidative phosphorylation; the classic symptom complex associated with toxicity of phenol-based products such as DNP is a combination of hyperthermia, tachycardia, diaphoresis and tachypnoea, eventually leading to death. Fatalities related to exposure to DNP have been reported since the turn of the twentieth century. To date, there have been 62 published deaths in the medical literature attributed to DNP. In this review, we will describe the pattern and pathophysiology of DNP toxicity and summarise the previous fatalities associated with exposure to DNP.

show abstract

Functional Changes in Liver, Heart and Muscles, and Loss of Dextrose Tolerance

Cited by 19 publications

References 36 publications

Non‐Cardiotoxic Tetradecanoic Acid‐2,4‐Dinitrophenol Ester Nanomicelles in Microneedles Exert Potent Anti‐Obesity Effect by Regulating Adipocyte Browning and Lipogenesis

Non‐Cardiotoxic Tetradecanoic Acid‐2,4‐Dinitrophenol Ester Nanomicelles in Microneedles Exert Potent Anti‐Obesity Effect by Regulating Adipocyte Browning and Lipogenesis

Inhibition of Alzheimer's disease β‐amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

Contact Info

Product

Resources

About