Reply to Happle R. <i>et al</i>. Koebner's sheep in Wolf's clothing: does the isotopic response exists as a distinct phenomenon?

Nwabudike, Lawrence Chukwudi; Tatu, Alin Laurențiu

doi:10.1111/jdv.14900

Cited by 23 publications

(31 citation statements)

References 9 publications

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“…It has also been proposed that the Wolf isotopic response be viewed as a variant of the Koebner reaction, perhaps a type V Koebner. 10 This case might also fall into this category.…”

Section: Reply To Gambichler T Et Almentioning

confidence: 99%

Reply to Gambichler T et al.: Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery

Nwabudike

Tatu

2018

Acad Dermatol Venereol

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“…It has also been proposed that the Wolf isotopic response be viewed as a variant of the Koebner reaction, perhaps a type V Koebner. 10 This case might also fall into this category.…”

Section: Reply To Gambichler T Et Almentioning

confidence: 99%

Reply to Gambichler T et al.: Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery

Nwabudike

Tatu

2018

Acad Dermatol Venereol

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“…Psoriasis is a chronic immunologically mediated dermatosis, affecting 2-3% of the general population (1)(2)(3). Multiple mechanisms are involved in its pathogenesis, such as the hyper-reactivity of T-lymphocytes and dendritic cells, excessive inflammatory cytokine synthesis, accelerated epidermal turnover, epidermal hyperproliferation, reduced keratinocyte differentiation, overexpression of angiogenesis and oxidative stress (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). The extent of skin involvement is variable, ranging from several psoriatic plaques to generalized forms.…”

Section: Introductionmentioning

confidence: 99%

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

et al. 2018

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Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, monitored over a 5-year period. Alterations of renal function, albumin/creatinine ratio (ACR, mg/g) and UA/creatinine ratio (UACR, mg/mg) were determined in spontaneous urine samples. The status of related-purine derivatives was evaluated by quantification of uric acid (UA, mg/dl), adenosine deaminase (ADA, UI/mg protein), xanthine oxidase (XO, UI/mg protein) and 8-hydroxy-deoxy-guanosine levels (8-OHdG, ng/ml) in serum samples. Compared to the controls, in patients with psoriasis there was an increase in related-purine derivatives levels, which was demonstrated by the elevated serum levels of UA (5.1±0.4 vs. 5.4±1.0, P=0.066), ADA (0.14±0.08 vs. 0.29±0.12, P=0.052), XO (0.22±0.11 vs. 0.42±0.21, P=0.011) and 8-OHdG (3.1±0.05 vs. 8.3±4.7, P=0.002). The serum levels of related-purine derivatives were associated with the severity of psoriasis. In addition, there was a link between the serum levels of related-purine derivatives and markers of renal impairment. There were positive correlations between 8-OHdG and ACR (r=0.452, P=0.028) and between ADA, XO, UA, 8-OHdG and UACR (r=0.297 and P=0.032, r=0.301 and P=0.002, r=0.431 and P=0.027, r=0.508 and P=0.002) and negative correlations between UA, 8-OHdG and the estimated glomerular filtration rate (r=-0.301 and P= 0.036, r=-0.384 and P= 0.002). Thus, severe psoriasis is a risk factor for the development of renal disease.

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“…Forton and De Maertelaer may be right. 1 The argument has been made regarding the need to avoid duplicating phenomena 8 by creating new diseases when they could in fact be variants of the same disease. Both 'disorders' may be phenotypes of the same disorder.…”

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confidence: 99%

Rosacea‐like demodicosis (but not primary demodicosis) and papulopustular rosacea may be two phenotypes of the same disease – a microbioma, therapeutic and diagnostic tools perspective

Tatu

Clătici

Nwabudike³

2018

Acad Dermatol Venereol

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Reply to Happle R. et al. Koebner's sheep in Wolf's clothing: does the isotopic response exists as a distinct phenomenon?

Cited by 23 publications

References 9 publications

Reply to Gambichler T et al.: Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery

Reply to Gambichler T et al.: Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris

Rosacea‐like demodicosis (but not primary demodicosis) and papulopustular rosacea may be two phenotypes of the same disease – a microbioma, therapeutic and diagnostic tools perspective

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