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Lei, Fang; Liu, Ye Mao; Zhou, Feng; Qin, Juan Juan; Huang, Xiaodong; Zhang, Bing Hong; Li, Hongliang; Yuan, Yufeng

doi:10.1002/hep.31449

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…There was no difference in the incidence of acute liver injury between the two groups. Similar to previous studies, the prevalence of abnormal liver function tests (LFTs) was high in COVID-19 patients, whereas acute liver injury was usually mild, with limited clinical relevance and no treatment required [ 19 – 21 ].…”

Section: Discussionsupporting

confidence: 69%

Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study

et al. 2020

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Background Information regarding characteristics and risk factors of COVID-19 amongst middle-aged (40–59 years) patients without comorbidities is scarce. Methods We therefore conducted this multicentre retrospective study and collected data of middle-aged COVID-19 patients without comorbidities at admission from three designated hospitals in China. Results Among 119 middle-aged patients without comorbidities, 18 (15.1%) developed into severe illness and 5 (3.9%) died in hospital. ARDS (26, 21.8%) and elevated D-dimer (36, 31.3%) were the most common complications, while other organ complications were relatively rare. Multivariable regression showed increasing odds of severe illness associated with neutrophil to lymphocyte ratio (NLR, OR, 11.238; 95% CI 1.110–1.382; p < 0.001) and D-dimer greater than 1 µg/ml (OR, 16.079; 95% CI 3.162–81.775; p = 0.001) on admission. The AUCs for the NLR, D-dimer greater than 1 µg/ml and combined NLR and D-dimer index were 0.862 (95% CI, 0.751–0.973), 0.800 (95% CI 0.684–0.915) and 0.916 (95% CI, 0.855–0.977), respectively. SOFA yielded an AUC of 0.750 (95% CI 0.602–0.987). There was significant difference in the AUC between SOFA and combined index (z = 2.574, p = 0.010). Conclusions More attention should be paid to the monitoring and early treatment of respiratory and coagulation abnormalities in middle-aged COVID-19 patients without comorbidities. In addition, the combined NLR and D-dimer higher than 1 μg/ml index might be a potential and reliable predictor for the incidence of severe illness in this specific patient with COVID-19, which could guide clinicians on early classification and management of patients, thereby relieving the shortage of medical resource. However, it is warranted to validate the reliability of the predictor in larger sample COVID-19 patients.

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Section: Discussionsupporting

confidence: 69%

Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study

et al. 2020

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“…On the other hand, immunosuppressive drugs may delay viral clearance in post-transplant patients who have contracted COVID-19 [ 47 ].…”

Section: Liver Transplantation and Covid-19mentioning

confidence: 99%

From advanced disease to transplantation: an overview of the liver at the time of COVID-19 pandemic

et al. 2021

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In 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also known as coronavirus disease 2019 (COVID-19) disrupted global health, causing hundreds of thousands of deaths worldwide. The liver injury appears to be one of the possible systemic manifestations of COVID-19 disease although the mechanisms causing such injury are not entirely clear. At the beginning of the pandemic, patients with chronic diseases, such as liver cirrhosis, or special populations, such as liver transplant recipients, were considered at higher risk of complications and poor clinical outcomes. Thus, the national transplant programmes have been severely hampered by the COVID-19 pandemic. Furthermore, liver transplant patients are potentially more vulnerable to SARS-CoV-2 infection due to immune suppression, ageing, and metabolic or cardiovascular comorbidities. This review analyses the increasing amounts of data collected in recent months concerning liver cirrhosis and liver transplants to understand if this finding is still relevant with respect to COVID-19 manifestations.

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Cited by 2 publications

References 5 publications

Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study

Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study

From advanced disease to transplantation: an overview of the liver at the time of COVID-19 pandemic

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