Reply: Gallstones, cholecystectomy, and the risk for developing pancreatic cancer

Bosetti, Cristina; Negri, Eva; Franceschi, Silvia; Vecchia, Carlo La

doi:10.1038/sj.bjc.6600693

Cited by 3 publications

(2 citation statements)

References 9 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings showed no relationship between the conditions cholecystectomy and gallstones and pancreatic cancer risk. In some case-control studies, positive associations were observed for cholecystectomy and gallstones ( Lee et al , 1996 ; Silverman, 2001 ; Ghadirian et al , 2003 ; Ko et al , 2007 ), whereas other cohort studies and case-control studies reported null results ( Gullo et al , 1996 ; Ye et al , 2001 ; Schernhammer et al , 2002 ; Bosetti et al , 2003 ; Hassan et al , 2007 ). We also did not observe an association between peptic ulcer and pancreatic cancer risk.…”

Section: Discussionmentioning

confidence: 98%

Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands

et al. 2013

View full text Add to dashboard Cite

Background:To date, only a few risk factors for pancreatic cancer have been established. We examined prospectively relations between several medical conditions and pancreatic cancer incidence.Methods:In 1986, 120 852 participants completed a baseline questionnaire on cancer risk factors, including several self-reported physician diagnosed medical conditions. At baseline, a random subcohort of 5000 participants was selected using a case-cohort approach for analysis. After 16.3 years of follow-up, 448 pancreatic cancer cases (63% microscopically confirmed) were available for analysis.Results:Diabetes mellitus type II and hepatitis were positively associated with pancreatic cancer risk (multivariable-adjusted hazard ratio: 1.79; 95% confidence interval: 1.12–2.87 and hazard ratio: 1.37; 95% confidence interval: 1.04–1.81, respectively). Furthermore, a positive trend in risk with increasing years of diagnosis of diabetes (P=0.004) and of hepatitis (P=0.02) was observed. However, an inverse association was observed between hypertension and pancreatic cancer risk, this was found among microscopically confirmed cases only (hazard ratio: 0.66; 95% confidence interval: 0.49–0.90), while years since diagnosis of hypertension significantly decreased cancer risk (P for trend=0.02).Conclusion:In this prospective study, a positive association was observed between self-reported physician diagnosed diabetes mellitus type II and hepatitis and pancreatic cancer risk, whereas an inverse association was observed with hypertension.

show abstract

Section: Discussionmentioning

confidence: 98%

Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands

et al. 2013

View full text Add to dashboard Cite

show abstract

“…However, the PC risk did not increase in the non-diabetic patients with gallstones, cholecystitis, or cholecystectomy. It should be considered that several studies could not show any statistically significant association between cholecystectomy and PC, such as the combined analysis of the Nurses' Health Study and the Health Professional Follow-up Study (Schernhammer et al 2002), or the study by Bosetti et al (2003).…”

Section: E Cholecystectomy Appendectomy and Tonsillectomymentioning

confidence: 99%

Environmental risk factors for pancreatic cancer: an update

et al. 2016

View full text Add to dashboard Cite

Pancreatic cancer (PC) is one of the most aggressive diseases. Only 10 % of all PC cases are thought to be due to genetic factors. Here, we analyzed the most recently published case-control association studies, meta-analyses, and cohort studies with the aim to summarize the main environmental factors that could have a role in PC. Among the most dangerous agents involved in the initiation phase, there are the inhalation of cigarette smoke, and the exposure to mutagenic nitrosamines, organ-chlorinated compounds, heavy metals, and ionizing radiations. Moreover, pancreatitis, high doses of alcohol drinking, the body microbial infections, obesity, diabetes, gallstones and/or cholecystectomy, and the accumulation of asbestos fibers seem to play a crucial role in the progression of the disease. However, some of these agents act both as initiators and promoters in pancreatic acinar cells. Protective agents include dietary flavonoids, marine omega-3, vitamin D, fruit, vegetables, and the habit of regular physical activity. The identification of the factors involved in PC initiation and progression could be of help in establishing novel therapeutic approaches by targeting the molecular signaling pathways responsive to these stimuli. Moreover, the identification of these factors could facilitate the development of strategies for an early diagnosis or measures of risk reduction for high-risk people.

show abstract

Gallstones, a cholecystectomy, chronic pancreatitis, and the risk of subsequent pancreatic cancer in diabetic patients: a population-based cohort study

et al. 2012

View full text Add to dashboard Cite

Reply: Gallstones, cholecystectomy, and the risk for developing pancreatic cancer

Cited by 3 publications

References 9 publications

Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands

Diabetes type II, other medical conditions and pancreatic cancer risk: a prospective study in The Netherlands

Environmental risk factors for pancreatic cancer: an update

Gallstones, a cholecystectomy, chronic pancreatitis, and the risk of subsequent pancreatic cancer in diabetic patients: a population-based cohort study

Contact Info

Product

Resources

About