To estimate the incidence of postoperative development of macular edema among diabetic patients with and without diabetic retinopathy. A comparative study of central macular thickness was performed on this population before and after uncomplicated cataract surgery. Methods: Forty-two diabetic patients with no diabetic retinopathy (no DR) and 23 diabetic patients with diabetic retinopathy (DR) that underwent phacoemulsification with intraocular lens implantation were enrolled in this study from March 2017 to May 2018. Central macular thickness (CMT) was measured with spectral domain optical coherence tomography (OCT). These parameters were recorded before and four-weeks after cataract surgery then analyzed using descriptive statistics. Results: 65 patients consisted of 40 males (61.54%) and 25 females (38.46%). Mean age was 67.01 ± 8.12 years. All 65 patients had diabetes, of which 23 (35.38%) had diabetic retinopathy and 42 (64.62%) did not. Phacoemulsification with posterior chamber intraocular lens implantation were performed in all eyes. No serious intraoperative complications were found.