Replicative difference in early-passage feline brain cells among feline immunodeficiency virus isolates

Kawaguchi, Yasushi; Maeda, Ken; Tohya, Yukinobu; Furuya, Tetsuya; Miyazawa, Takayuki; Horimoto, Taisuke; Norimine, Junzo; Kai, Chieko; Mikami, Takeshi

doi:10.1007/bf01309653

Cited by 22 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HIV-1 strains show various cell tropisms, and most isolates of HIV-1 infect CD 4-positive cells [8,9], but certain isolates can infect CD 4-negative cells such as glial cells [7,34] and fibroblasts [28]. Recently, different cell tropisms among FIV isolates in vitro were reported [14]. The FIV strains used in this study showed some variation in host cell range; while Petaluma and KYO-1 strains infected CRFK cells and fetal feline brain cells, TM 1 IC did not infect these cells and seems to be highly T lymphotropic.…”

Section: Discussionmentioning

confidence: 98%

Localization of the viral antigen of feline immunodeficiency virus in the lymph nodes of cats at the early stage of infection

Toyosaki

Miyazawa

Furuya

et al. 1993

Archives of Virology

Self Cite

View full text Add to dashboard Cite

Immunohistochemical examinations of localization of feline immunodeficiency virus (FIV) Gag protein were performed on lymph nodes of cats experimentally inoculated with three different strains of FIV (infectious molecular clone of TM 1, Petaluma, and KYO-1 strains), using rabbit anti-FIV Gag serum. The FIV Gag antigens were observed in many follicular dendritic cells (FDCs) and sparsely in small lymphocytes of paracortical area in the lymph nodes of cats inoculated with Petaluma and KYO-1 strains. However, the antigens were present only in small lymphocytes, and not in FDCs of a cat inoculated with infectious molecular clone of the TM1 strain. The cell type differences in expression of the viral antigen in vivo might reflect on the cell tropisms of the FIV strains in vitro. By double immunohistochemical staining with rabbit anti-FIV Gag serum and monoclonal antibodies which recognize feline CD4, feline CD8 or feline pan-T molecules, the FIV Gag-positive lymphocytes were characterized as feline CD4-positive T cells. Since the distributions of FIV Gag antigens were mainly in the FDCs, the FDCs may play an important role as a major reservoir and may be a primary target of FIV at early stages of infection.

show abstract

Section: Discussionmentioning

confidence: 98%

Localization of the viral antigen of feline immunodeficiency virus in the lymph nodes of cats at the early stage of infection

Toyosaki

Miyazawa

Furuya

et al. 1993

Archives of Virology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Different FIV isolates may differ in their in vitro host range even with respect to cells apparently showing the same surface phenotype (100,178,232). The reasons are not known but might involve differences in the Env protein as well as in the composition of the proviral LTR.…”

Section: Replication and Effects On Cells In Vitromentioning

confidence: 99%

Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen.

Bendinelli

Pistello

Lombardi

et al. 1995

Clinical Microbiology Reviews

141

View full text Add to dashboard Cite

“…Early studies on FIV tropism demonstrated that virus could be recovered from brain and CSF of infected cats (Dow et al 1990;Macchi et al 1998;Power et al 1997). In vitro studies of CNS cell tropism indicate that FIV can infect feline astrocytes Danave et al 1994;Dow et al 1990;Kawaguchi et al 1992;Yu et al 1998), microglia (Dow et al 1990;Hein et al 2000;Kawaguchi et al 1992), choroid plexus macrophages (Bragg et al 2002a), and perhaps brain microvascular endothelial cells (Steffan et al 1994). In vivo studies indicate that most virus production in the CNS is maintained by macrophages and microglia Hein et al 2000).…”

Section: Fiv Neurotropism and Neuropathogenesis Fiv Neurotropismmentioning

confidence: 99%

Feline Immunodeficiency Virus Neuropathogenesis: From Cats to Calcium

Meeker

2006

Jrnl Neuroimmune Pharm

View full text Add to dashboard Cite

Invasion of human immunodeficiency virus (HIV) into the central and peripheral nervous system produces a wide range of neurological symptoms, which continue to persist even with adequate therapeutic suppression of the systemic viremia. The development of therapies designed to prevent the neurological complications of HIV require a detailed understanding of the mechanisms of virus penetration into the nervous system, infection, and subsequent neuropathogenesis. These processes, however, are difficult to study in humans. The identification of animal lentiviruses similar to HIV has provided useful models of HIV infection that have greatly facilitated these efforts. This review summarizes contributions made from in vitro and in vivo studies on the infectious and pathological interactions of feline immunodeficiency virus (FIV) with the nervous system. In vivo studies on FIV have provided insights into the natural progression of CNS disease as well as the contribution of various risk factors. In vitro studies have contributed to our understanding of immune cell trafficking, CNS infection and neuropathogenesis. Together, these studies have made unique contributions to our understanding of (1) lentiviral interactions at the blood-cerebrospinal fluid (CSF) barrier within the choroid plexus, (2) early FIV invasion and pathogenesis in the brain, and (3) lentiviral effects on intracellular calcium deregulation and neuronal dysfunction. The ability to combine in vitro and in vivo studies on FIV offers enormous potential to explore neuropathogenic mechanisms and generate information necessary for the development of effective therapeutic interventions.

show abstract

Replicative difference in early-passage feline brain cells among feline immunodeficiency virus isolates

Cited by 22 publications

References 28 publications

Localization of the viral antigen of feline immunodeficiency virus in the lymph nodes of cats at the early stage of infection

Localization of the viral antigen of feline immunodeficiency virus in the lymph nodes of cats at the early stage of infection

Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen.

Feline Immunodeficiency Virus Neuropathogenesis: From Cats to Calcium

Contact Info

Product

Resources

About