Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen.

Bendinelli, Mauro; Pistello, Mauro; Lombardi, Sara; Poli, Andrea; Garzelli, Carlo; Matteucci, Donatella; Ceccherini‐Nelli, Luca; Malvaldi, Gino; Tozzini, F.

doi:10.1128/cmr.8.1.87-112.1995

Cited by 99 publications

(167 citation statements)

References 186 publications

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“…In addition, CD8 T-cells from FIV-infected cats produced soluble suppressor antiviral factors resembling the CD8-mediated antiviral factor (CAF) produced in HIV-positive individuals (Flynn et al, 1999;Choi et al, 2000). Infected cats possess strong T-helper activities (increased gamma interferon and IL-10 production), during early stages of FIV infection which gradually decrease with long-term infection Torten et al, 1991;Hoffmann-Fezer et al, 1992;Bendinelli et al, 1995;Liang et al, 2000). These T-cell dysfunctions and responses in FIV-infected cats closely mimic those of HIV-positive individuals (Rideout et al, 1992;Gebhard et al, 1999).…”

Section: Pathogenesis and Infectionmentioning

confidence: 99%

“…Similar to HIV-1 with at least nine subtypes or clades (clades A±D, F±H, J, and K) in the predominant group M, FIV has been classi®ed into ®ve clades (clades A±E) with much smaller intraclade heterogeneity (Bachmann et al, 1997;Inoshima et al, Veterinary Immunology and Immunopathology 90 (2002) 113±132 1998; Yamaguchi et al, 2002;Blackard et al, 2002). Although in the same Retrovirinae family as the oncovirus, feline leukemia virus (FeLV), FIV more closely resembles HIV in morphology, pathogenesis, and genetic sequence (Bendinelli et al, 1995;Yamamoto, 1999). As a result of the increase in worldwide prevalence and severity of the disease, the development of an effective vaccine is imperative for veterinary medicine (Fauci et al, 1991;Bendinelli et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Although in the same Retrovirinae family as the oncovirus, feline leukemia virus (FeLV), FIV more closely resembles HIV in morphology, pathogenesis, and genetic sequence (Bendinelli et al, 1995;Yamamoto, 1999). As a result of the increase in worldwide prevalence and severity of the disease, the development of an effective vaccine is imperative for veterinary medicine (Fauci et al, 1991;Bendinelli et al, 1995). However, effective FIV vaccine development faces similar challenges and obstacles involving broad cross-subtype protection, individual mutations, and inter-subtype recombination, as does effective HIV vaccine development.…”

Section: Introductionmentioning

confidence: 99%

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FIV vaccine development and its importance to veterinary and human medicine: a review

Uhl

Heaton-Jones

et al. 2002

Veterinary Immunology and Immunopathology

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Feline immunodeficiency virus (FIV) is a natural infection of domestic cats that results in acquired immunodeficiency syndrome resembling human immunodeficiency virus (HIV) infection in humans. The worldwide prevalence of FIV infection in domestic cats has been reported to range from 1 to 28%. Hence, an effective FIV vaccine will have an important impact on veterinary medicine in addition to being used as a small animal AIDS model for humans. Since the discovery of FIV reported in 1987, FIV vaccine research has pursued both molecular and conventional vaccine approaches toward the development of a commercial product. Published FIV vaccine trial results from 1998 to the present have been compiled to update the veterinary clinical and research communities on the immunologic and experimental efficacy status of these vaccines. A brief report is included on the outcome of the 10 years of collaborative work between industry and academia which led to recent USDA approval of the first animal lentivirus vaccine, the dual-subtype FIV vaccine. The immunogenicity and efficacy of the experimental prototype, dual-subtype FIV vaccine and the efficacy of the currently approved commercial, dual-subtype FIV vaccine (Fel-O-Vax FIV) are discussed. Potential cross-reactivity complications between commercial FIV diagnostic tests, Idexx Snap Combo Test and Western blot assays, and sera from previously vaccinated cats are also discussed. Finally, recommendations are made for unbiased critical testing of new FIV vaccines, the currently USDA approved vaccine, and future vaccines in development.

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Section: Pathogenesis and Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

FIV vaccine development and its importance to veterinary and human medicine: a review

Uhl

Heaton-Jones

et al. 2002

Veterinary Immunology and Immunopathology

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“…Feline immunodeficiency virus in domestic cats (FIVfca) produces an AIDS like pathology characterized by CD4 depletion, immune suppression, and death (Bendinelli et al, 1995;Willett et al, 1997). As such, it is the only natural model for HIV/AIDS.…”

mentioning

confidence: 99%

FIV cross-species transmission: An evolutionary prospective

Troyer

VandeWoude

Pecon-Slattery

et al. 2008

Veterinary Immunology and Immunopathology

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Feline and primate immunodeficiency viruses (FIVs, SIVs, and HIV) are transmitted via direct contact (e.g. fighting, sexual contact, and mother-offspring transmission). This dynamic likely poses a behavioral barrier to cross-species transmission in the wild. Recently, several host intracellular anti-viral proteins that contribute to species-specificity of primate lentiviruses have been identified revealing adaptive mechanisms that further limit spread of lentiviruses between species. Consistent with these inter-species transmission barriers, phylogenetic evidence supports the prediction that FIV transmission is an exceedingly rare event between free-ranging cat species, though it has occurred occasionally in captive settings. Recently we documented that puma and bobcats in Southern California share an FIV strain, providing an opportunity to evaluate evolution of both viral strains and host intracellular restriction proteins. These studies are facilitated by the availability of the 2X cat genome sequence annotation. In addition, concurrent viral and host genetic analyses have been used to track patterns of migration of the host species and barriers to transmission of the virus within the African lion. These studies illustrate the utility of FIV as a model to discover the variables necessary for establishment and control of lentiviral infections in new species. Keywords FIV; lentiviruses; cross-species transmission Mini reviewFeline immunodeficiency virus in domestic cats (FIVfca) produces an AIDS like pathology characterized by CD4 depletion, immune suppression, and death (Bendinelli et al., 1995;Willett et al., 1997). As such, it is the only natural model for HIV/AIDS. Similar to the primate lentiviruses, closely related FIVs circulate in non-domestic cat species (Olmsted et al., 1992;Troyer et al., 2005). While antibodies that cross-react to FIV are detectable at a low percentage in most feline species and in the Hyeanidae , little is known about these Jennifer Troyer, Ph.D., Staff Scientist, SAIC_Frederick, Laboratory of Genomic Diversity, NIC-Frederick, Frederick, MD 21702, Telephone: 301-846-7478, Fax: 301-846-1909, jtroyer@ncifcrf.gov. Conflict of Interest Statement:None of the authors has a financial or personal relationship with other people or organizations that could inappropriately influence or bias the paper entitled "FIV cross-species transmission: an evolutionary prospective".Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. In the absence of comprehensive datasets, what can be discerned about these non-domestic cat lentiviruses and how does this knowl...

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“…FIV is now widely spread among domestic cats throughout the world including Europe, the United States, Australia, Vietnam, Taiwan and Japan (Ishida et al, 1989;Lin et al, 1995;Malik et al, 1997;Nakamura et al, 2000;Steinrigl and Klein, 2003;Yamamoto et al, 1989). FIV-infected cats show various degree of immunological impairment resulting in the clinical symptoms including gingivitis, www.elsevier.com/locate/vetmic Veterinary Microbiology 120 (2007) 207-216 stomatitis, upper respiratory tract infections, myelosuppression and opportunistic infections (Bendinelli et al, 1995;Pedersen and Barlough, 1991;Shelton et al, 1990). Because of the prevalence and various clinical outcomes, FIV infection has been considered as one of the most problematic diseases in small animal practice.…”

Section: Introductionmentioning

confidence: 99%

Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines

Baba

Mizukoshi

Goto‐Koshino

et al. 2007

Veterinary Microbiology

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RNA interference (RNAi) is a process in which double-stranded RNA induces the post-transcriptional sequence-specific degradation of homologous messenger RNA. The present study was carried out to apply the RNAi technology to inhibit the replication of feline immunodeficiency virus (FIV). Four small interfering RNAs (siRNAs) homologous to the FIV gag gene were synthesized and transfected into a feline fibroblastic cell line chronically infected with FIV (CRFK/FIV). These synthetic siRNAs efficiently inhibited the replication of FIV. Next, we examined the effect of retroviral vector-mediated transfer of FIV-specific short hairpin RNA (shRNA) on the replication of FIV in a feline T-cell line chronically infected with FIV (FL4). The retroviral vector-mediated transfer of FIV-specific shRNA was shown to markedly inhibit the replication of FIV in the FL4 cells. These results provide useful information for the development of RNAi-based gene therapy strategy to control FIV infection.

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Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen.

Cited by 99 publications

References 186 publications

FIV vaccine development and its importance to veterinary and human medicine: a review

FIV vaccine development and its importance to veterinary and human medicine: a review

FIV cross-species transmission: An evolutionary prospective

Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines

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