Replication of an Avian Adenovirus (CELO) Large-Plaque Mutant in Chick Kidney Cells 1. An Electron-Microscope Study

Jasty, V.; Yates, Vance J.; Anderson, Jeffrey P.; Fry, D. E.; Chang, P. W.; Pendola, R.

doi:10.2307/1588919

Cited by 7 publications

(9 citation statements)

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“…Similar changes were described by Petek et al (1963 and in cells infected with FAV-1. Jasty et al (1973) also reported the development of single bundles of parallel fibres in FAV-1 infected cells. It may be significant that these structures have only been described with oncogenic adenoviruses.…”

Section: Effect Of Physical and Chemical Agentsmentioning

confidence: 94%

“…Later, FAV-2 virus was shown to be similar in size (Dutta and Pomeroy, 1967) and a type 8 virus (764) was shown by to have a mean diameter of 74 nm. FAV-1 particles seen in thin sections of chick embryo kidney cells had an estimated diameter of 70 nm (Petek et al, 1963 ;Jasty et al, 1973) and contained a central nucleoid measuring approximately 40 nm. Macpherson et al (1961) in a study of the fine structure of FAV-2 reported particles hexagonal in shape with well defined capsomeres.…”

Section: Properties Of Fowl Adenovirusesmentioning

confidence: 99%

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Avian adenoviruses ‐ a review

1977

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Section: Effect Of Physical and Chemical Agentsmentioning

confidence: 94%

Section: Properties Of Fowl Adenovirusesmentioning

confidence: 99%

Avian adenoviruses ‐ a review

1977

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“…FAV-1 (Phelps) belongs to cytopathology subgroup -1 (Adair, 1978) which also includes FAV-2, FAV-4, FAV-5 (strains 340 and Tipton) and [58][59]. It was selected for study for comparative purposes, since its development in cell cultures has been described in detail previously (Slifkin et al, 1971 ;Jasty et al, 1973). FAV-7 (strain YR-36) is a typical member of cytopathology subgroup 2 which also comprises FAV-3, FAV-5 (strain TR-22), FAV-6 and FAV-8 (strain 764).…”

Section: Viruses and Virus Poolsmentioning

confidence: 99%

“…FAV-1 (CELO, Phelps). Electron microscope observations of avian cells infected with FAV-1 have been described (Slifkin et al, 1971 ;Jasty et al, 1973). However, Maeda etal.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural studies of the replication of fowl adenoviruses in primary cell cultures

1979

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SUMMARYThe replication of four fowl adenovirus strains (FAV-1, strain Phelps; , in primary chick kidney cell cultures, is described. Differences were found in the distribution of virus particles and virus associated inclusions between viruses belonging to different cytopathology subgroups. Thus in cells infected with FAV-1 (Phelps) and FAV-5 (340) (i.e. subgroup 1) virus particles, as they increased in number, tended to become distributed peripherally, close to the nuclear membranes, with the virus associated inclusions in the centre of the nucleus. With FAV-5 (TR-22) and FAV-7 (YR-36) (i.e. subgroup 2) virus particles and associated inclusions became concentrated initially in the central nuclear area later increasing to fill the whole nucleus, with virus particles and inclusions completely intermixed.The virus-associated inclusions were found to be identical to those described in human adenovirus infected cells and the same nomenclature was adopted. Other inclusions found in infected nuclei, included tubular structures and inclusions composed of granular particles.

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“…The ultrastructure of the basophilic inclusions was essentially the same as that of inclusions in the hepatic cells in the disorder experimentally induced with an adenovirus in chicks (Bickford etal, 1973), in cultured hepatic cells from birds naturally affected with IBH (Franco et al,\91 A), and in tissue culture cells infected with other avian adenoviruses (Jasty et al, 1973;Maeda et al, 1967;Mustaffa-Babjee and Spradbrow, 1975;Sharpless et al, 1961). Both viral particles and granular material, which are regarded as viroplasmic foci, are the main components of these inclusions.…”

Section: Inclusion Bodies Without Viral Particlesmentioning

confidence: 79%

Fine structure of inclusion bodies in hepatic cells of chickens naturally affected with inclusion body hepatitis

1977

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SUMMARYThe fine structure of intranuclear inclusion bodies in the hepatic cells of chickens naturally affected with inclusion body hepatitis was studied comparing them with the inclusions seen with light microscopy. Ultrastructurally the inclusions were classified into two types depending on whether they contained virus particles or not. The first type consisted of virus particles, granular material and loose granular material, and sometimes concentric-circular lamellae enclosing the virus core. It is suggested that the virus particles are adenoviruses. This type corresponded to the basophilic inclusions seen with light microscopy. The second type was without virus particles and was subdivided into two forms, one consisting of fibrillar-granular material and the other of crystals composed of filaments. These corresponded to the eosinophilic inclusions seen with light microscopy. Eosinophilic inclusions were present in all 20 cases of inclusion body hepatitis, whereas the basophilic inclusions were present in only six. The presence of adenovirus particles might suggest that they are the aetiology of this condition, although they were present in only six of the 20 cases examined. The significance of the inclusions without viral particles was not adequately elucidated, but it was suggested they are degenerating material present in cells dying from the effects of the viral infection. INTRODUCTIONSince the first report on inclusion body hepatitis of chickens (IBH) (Helmboldt and Frazier, 1963), it has been well recognised that intranuclear inclusion bodies in the hepatic cells is characteristic of the disease. The present authors and their co-worker (Itakura et al, 1974) reported that the inclusions in spontaneous IBH were divided into two types, one was eosinophilic and the other basophilic, and that the majority of inclusion were of the eosinophilic type.

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Replication of an Avian Adenovirus (CELO) Large-Plaque Mutant in Chick Kidney Cells 1. An Electron-Microscope Study

Cited by 7 publications

References 0 publications

Avian adenoviruses ‐ a review

Avian adenoviruses ‐ a review

Ultrastructural studies of the replication of fowl adenoviruses in primary cell cultures

Fine structure of inclusion bodies in hepatic cells of chickens naturally affected with inclusion body hepatitis

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