Repigmentation of Vitiligo Lesions in a Child with Celiac Disease after a Gluten‐Free Diet

Celiac disease (CD) is frequently accompanied by a variety of extradigestive manifestations, thus making it a systemic disease rather than a disease limited to the gastrointestinal tract. This is primarily explained by the fact that CD belongs to the group of autoimmune diseases. The only one with a known etiology is related to a permanent intolerance to gluten. Remarkable breakthroughs have been achieved in the last decades, due to a greater interest in the diagnosis of atypical and asymptomatic patients, which are more frequent in adults. The known presence of several associated diseases provides guidance in the search of oligosymptomatic cases as well as studies performed in relatives of patients with CD. The causes for the onset and manifestation of associated diseases are diverse; some share a similar genetic base, like type 1 diabetes mellitus (T1D); others share pathogenic mechanisms, and yet, others are of unknown nature. General practitioners and other specialists must remember that CD may debut with extraintestinal manifestations, and associated illnesses may appear both at the time of diagnosis and throughout the evolution of the disease. The implementation of a gluten-free diet (GFD) improves the overall clinical course and influences the evolution of the associated diseases. In some cases, such as iron deficiency anemia, the GFD contributes to its disappearance. In other disorders, like T1D, this allows a better control of the disease. In several other complications and/or associated diseases, an adequate adherence to a GFD may slow down their evolution, especially if implemented during an early stage.

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“…Although some cases of both diseases have been described, this association remains unclear [135, 136]. …”

Section: Autoimmune Disorders In Celiac Diseasementioning

confidence: 99%

Celiac Disease and Autoimmune-Associated Conditions

Lauret

Rodrigo

2013

BioMed Research International

145

111

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“…CD is commonly associated with certain dermatologic conditions, including vitiligo. There have been case reports describing resolution of vitiligo in children with CD after instituting a gluten‐free diet . In the cases of the above three children, starting a gluten‐free diet did not appear to change the course of the LS.…”

Section: Discussionmentioning

confidence: 84%

Association Between Lichen Sclerosus and Celiac Disease: A Report of Three Pediatric Cases

Jacobs

Gilliam

Khavari

et al. 2014

Pediatric Dermatology

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The prevalence of celiac disease (CD) is increasing and may be as high as 1% of the US population. The typical presentation of CD generally includes gastrointestinal symptoms, but more individuals are presenting with extraintestinal manifestations. A wide variety of dermatologic associations have been described with CD, including alopecia, dermatitis herpetiformis, and enamel hypoplasia. In this report we describe three girls with CD who presented with hypopigmented skin lesions and pruritus in the perivaginal and perianal areas, consistent with the diagnosis of lichen sclerosus (LS). All three presented within 1 year to the same practitioner. To our knowledge, this association has not previously been explored in the literature. These cases elucidate a possible relationship between CD and LS.

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“…In one case report, a 9-year old child with celiac disease experienced extensive repigmentation over three years following the initiation of a gluten-free diet. Seven years later, with the continuation of the gluten-free diet, the repigmentation was maintained [31]. Another case report indicated that a 22-year old female with acrofacial vitiligo experienced significant repigmentation following the initiation of a gluten-free diet, even though she did not have celiac disease.…”

Section: B Gluten-free Dietmentioning

confidence: 98%

Assessment of Dietary Supplementation in the Treatment of Vitiligo

Smith¹,

Mohammad²,

Hamzavi³

2017

TODJ

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Background:Vitiligo is the most common acquired pigmentary disorder in the world. Due to alterations in physical appearance, vitiligo is a psychologically devastating disease. Although treatment options exist, a cure for this disease has yet to be discovered. Of recent interest in vitiligo is the relationship between diet and disease. Objective:To review various dietary modifications and supplementation used in the management of vitiligo. Materials and Methods:A thorough evaluation of recent literature using the keywords "vitiligo, diet, supplement, antioxidant, vitamin, mineral, zinc, copper, gluten-free, celiac disease, alternative medicine" in the NCBI PubMed search function was performed. Results:A total of 39 relevant articles were reviewed and critically evaluated. Conclusion:Initial studies regarding the treatment of vitiligo through dietary modification are promising, although further studies are needed in multiple populations to explore the therapeutic value of these interventions.

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Repigmentation of Vitiligo Lesions in a Child with Celiac Disease after a Gluten‐Free Diet

Cited by 29 publications

References 7 publications

Celiac Disease and Autoimmune-Associated Conditions

Celiac Disease and Autoimmune-Associated Conditions

Association Between Lichen Sclerosus and Celiac Disease: A Report of Three Pediatric Cases

Assessment of Dietary Supplementation in the Treatment of Vitiligo

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