Repetitive shock wave therapy improves muscular microcirculation

Kisch, Tobias; Wuerfel, Waldemar; Forstmeier, Vinzent; Liodaki, Eirini; Stang, Felix; Knobloch, Karsten; Mailaender, Peter; Kraemer, Robert

doi:10.1016/j.jss.2015.11.049

Cited by 54 publications

(29 citation statements)

References 33 publications

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“…To accelerate the regeneration of injured bladder histopathology, defocused low-energy shock wave (DLSW) was applied in 2017 (Jin et al, 2017). DLSW is a novel therapeutic modality in regeneration medicine, as seen in newly published studies (Kisch et al, 2016;Sheu et al, 2015). However, its precise mechanisms remain unknown.…”

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confidence: 99%

A promising therapeutic option for diabetic bladder dysfunction: Adipose tissue‐derived stem cells pretreated by defocused low‐energy shock wave

Zhang

Zhao

Wang

et al. 2019

J Tissue Eng Regen Med

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Adipose tissue‐derived stem cells (ADSCs) have shown effectiveness in treating diabetic bladder dysfunction (DBD). In the present study, ADSCs pretreated by defocused low‐energy shock wave (DLSW) were first used to achieve better therapeutic effect. ADSCs were treated by DLSW prior to each passage. Secretions of vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) were tested. Proliferation ability was examined by staining 5‐ethynyl‐2‐deoxyuridine (EdU) and assessing expressions of proliferating cell nuclear antigen (PCNA) and Ki67. DBD rat model was created and subgrouped via therapeutic options of phosphate‐buffered saline, ADSCs, pretreated ADSCs, and ADSCs lysate. Afterward, voiding functions were evaluated, and tissues were examined by histology. Neonatal rats received intraperitoneal injection of EdU. All rats were subgrouped and treated as narrated above. Bladder tissues were stained with EdU, Stro‐1, and CD34. Results showed that shocked ADSCs were activated by secreting more VEGF and NGF, by higher EdU‐retaining cells ratios, and by higher expressions of PCNA and Ki67 compared with unshocked ADSCs. Shocked ADSCs had the most effective efficacy in treating DBD by secreting the most VEGF and NGF to accelerate regenerations of revascularization and innervation. Migrations of EdU+Stro‐1+CD34− endogenous stem cells to bladders were enhanced by injecting ADSCs. In conclusion, ADSCs pretreated by DLSW had potent therapeutic effect in treating DBD by secreting VEGF and NGF. Recruitment of endogenous stem cells was considered as an important mechanism in this regenerative process.

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confidence: 99%

A promising therapeutic option for diabetic bladder dysfunction: Adipose tissue‐derived stem cells pretreated by defocused low‐energy shock wave

Zhang

Zhao

Wang

et al. 2019

J Tissue Eng Regen Med

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“…Particularly interesting, for future prospective, is the study of Vitali et al [38]. The authors highlighted that the combination of ESWT and dietary supplementation produced an increased bioavailability of the supplement to the tendon tissue, due to the neo-angiogenic properties [39,40].…”

Section: Discussionmentioning

confidence: 99%

Functional Outcome at Short and Middle Term of the Extracorporeal Shockwave Therapy Treatment in Lateral Epicondylitis: A Case-Series Study

Testa

Vescio

Perez

et al. 2020

JCM

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Lateral epicondylitis (LE) of the humerus is a chronic degeneration of wrist extensor tendons at their attachments to the lateral epicondyle of the humerus. There is not a common consensus on a specific therapeutic algorithm, but Extracorporeal Shockwave Therapy (ESWT) is widely used. The purpose of this study is to evaluate the clinical benefits of low dose ESWT in LE-affected patients in short and medium follow-up. Between January 2015 and December 2017, 60 patients (38 male, mean age 52.2 ± 10.1 years, the duration of the disease was 3.6 ± 1.3 months) were clinically evaluated using visual analog scale (VAS) and Patient Rated Tennis Elbow Evaluation Test (PRTEE-I) scores before treatment, at one, three, six and 12 months after treatment. According to the VAS and PRTEE-I scoring systems, all patients achieved an improvement of pain and functional outcome comparing the baseline results with one, six and 12 months values. Low dose ESWT is a safe and effective treatment of LE in the short and middle term. In elderly subjects, patients with a long disease history, or those with occupational and sportive risk factors, a longer persistence of the symptomatology could be observed.

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“…In the past, the mechanism by which ESWT acts on musculoskeletal diseases was assumed to be mechanical decomposition, just like extracorporeal shock wave lithotripsy. However, further clinical observations and experimental results, have suggested that ESWT can promote neovascularization, the release of growth factors, the differentiation of mesenchymal stem cells and the production of endogenous nitric oxides (NOs) [46][47][48], which can decrease the intrinsic stiffness of connective tissue, increase muscle elongation, improve tissue microcirculation and change the formation of neuromuscular junctions of the peripheral nervous system [49][50][51], in order to achieve encouraging clinical results.…”

Section: Discussionmentioning

confidence: 99%

Effects of Radial Extracorporeal Shock Wave Therapy on Flexor Spasticity of the Upper Limb in Post-stroke Patients: Study Protocol for A Randomized Controlled Trial

Fan

Zhou

et al. 2020

Preprint

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Background: Flexor Spasticity of the Upper Limb is common in post-stroke patients and seriously affects the recovery of upper limb function. However, there are no standard management protocols for this condition. Radial extracorporeal shock wave therapy (rESWT) is widely used as a non-invasive treatment method for various diseases, but its efficacy in reducing spasticity remains undefined. Methods/design: A prospective, randomized, double-blind controlled trial is to be performed to study the efficacy of rESWT on the treatment of upper limb spasticity after strokes. One hundred participants will be recruited from the Inpatient department of Zhujiang hospital for this study. Patients who meet the inclusion criteria will be randomly allocated to either receive 3 sessions of active rESWT (Group A) or sham-placebo rESWT (Group B) with three day intervals between each session. Assessment will be performed at baseline and at each of the post-rESWT time points (t1, t2 and t3). The primary assessment outcome will be the Modified Ashworth Scale, while the secondary assessment outcomes will include surface electromyography, MyotonPRO digital muscle function evaluation and infrared thermal imaging. Discussion: This trial is aimed at analyzing the application of rESWT for the management of spasticity after stroke via comprehensive and quantitative assessments. We hypothesized that after receiving active rESWT, patients will show greater improvement of upper limb muscles, compared with patients of the sham-placeborESWT group. The rESWT would be an attractive alternative to traditional methods and the results of this study may provide guidance and support for the further study of potential mechanisms.

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Repetitive shock wave therapy improves muscular microcirculation

Cited by 54 publications

References 33 publications

A promising therapeutic option for diabetic bladder dysfunction: Adipose tissue‐derived stem cells pretreated by defocused low‐energy shock wave

A promising therapeutic option for diabetic bladder dysfunction: Adipose tissue‐derived stem cells pretreated by defocused low‐energy shock wave

Functional Outcome at Short and Middle Term of the Extracorporeal Shockwave Therapy Treatment in Lateral Epicondylitis: A Case-Series Study

Effects of Radial Extracorporeal Shock Wave Therapy on Flexor Spasticity of the Upper Limb in Post-stroke Patients: Study Protocol for A Randomized Controlled Trial

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