Repetitive calcium stimuli drive meiotic resumption and pronuclear development during mouse oocyte activation

Vitullo, Alfredo Daniel; Ozil, Jean-Pierre

doi:10.1016/0012-1606(92)90220-b

Cited by 128 publications

(92 citation statements)

References 27 publications

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“…Such meiotic "phenotype" perpetuating M-phases without interphases is, therefore, not directly linked to the unique characteristic of the MII state, but rather to the age of the oocyte and the stage of its cytoplasmic maturation. The capacity to mobilize calcium stores seems to be the key event in the response of the oocyte to activation stimulus (Vincent et al, 1992;Vitullo and Ozil, 1992;Dupont, 1998). In fertilized oocytes Ca 2+ increase is caused by the sperm-brought PLCζ that catalyzes hydrolysis of PIP2 to inositole triphosphate (IP3) and diacylogrycerol (DAG) (Cox et al, 2002;Saunders et al, 2002;Halet, 2004;Swann et al, 2004).…”

Section: Mii-arrest and Exit: Emi2 Calcium And Apc/c Do The Job Butmentioning

confidence: 99%

On the transition from the meiotic to mitotic cell cycle during early mouse development

Kubiak

Ciemerych²,

Hupalowska³

et al. 2008

Int. J. Dev. Biol.

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Here, we outline the mechanisms involved in the regulation of cell divisions during oocyte maturation and early cleavages of the mouse embryo. Our interest is focused on the regulation of meiotic M-phases and the first embryonic mitoses that are differently tuned and are characterized by specifically modified mechanisms, some of which have been recently identified. The transitions between the M-phases during this period of development, as well as associated changes in their regulation, are of key importance for both the meiotic maturation of oocytes and the further development of the mammalian embryo. The mouse is an excellent model for studies of the cell cycle during oogenesis and early development. Nevertheless, a number of molecular mechanisms described here were discovered or confirmed during the study of other species and apply also to other mammals including humans. KEY WORDS: meiosis, mitosis, oocyte, embryo, MPF, CSF, spindle assembly checkpoint, Mad2, Rec8Cell cycle is often modified in different cell types during development and aging of the individual. These adaptations seem to be of a particular importance for the success of the early developmental program. The cell cycle must be modified during meiosis, when DNA replication is suppressed, during spermatogenesis in males and in oocytes undergoing the process of meiotic maturation in females. The oocyte enters the first meiotic prophase that can take several years. Then, in sexually mature females, the oocyte resumes meiosis and progress through two M-phases of the meiotic maturation, each of them differently regulated, to assure correct separation of maternal chromatin. Fertilized egg transits from meiotic to the mitotic cell cycle and resume DNA replication.In the current review we will focus on M-phase modifications that are the subject of the research in our laboratories. We choose three examples of specific M-phase adjustments i.e. metaphase I, and metaphase II of oocyte meiotic divisions and the first mitosis of mouse embryo. We center our attention on the temporal regulation of metaphase I progression and the singularities of the spindle assembly checkpoint during this period, mechanisms of sustaining and exiting metaphase II-arrest, and finally the unique regulation of the first embryonic mitosis. The correct timing of Int.

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Section: Mii-arrest and Exit: Emi2 Calcium And Apc/c Do The Job Butmentioning

confidence: 99%

On the transition from the meiotic to mitotic cell cycle during early mouse development

Kubiak

Ciemerych²,

Hupalowska³

et al. 2008

Int. J. Dev. Biol.

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“…It is generally accepted that intracellular increase in calcium ion level is the universal signal for triggering oocyte activation in all animals studies so far [95][96][97], but it is unclear how this is initiated by the spermatozoa. There are two current hypotheses as to how the spermatozoon triggers meiotic progression in the quiescent oocyte.…”

Section: Oocyte Activationmentioning

confidence: 99%

Current Status and Future of Micromanipulation-Assisted Fertilization in Animals and Human.

Goto

1997

Journal of Reproduction and Development

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“…It has been shown that mammalian oocytes have the potential to decode a wide range of Ca 2þ signal regimens. For example, if the number of Ca 2þ oscillations can regulate the early events of egg activation (Vitullo & Ozil 1992, Lawrence et al 1998, Ducibella et al 2002 as well as pre-and post-implantation development of parthenotes (Ozil & Huneau 2001), a single and large monotonic increase in the [Ca 2þ ] i (intracellular Ca 2þ concentration) can also activate the egg and promote parthenogenetic preimplantation development (Cuthbertson 1983, Surani et al 1984, Ozil et al 2005. It has recently been shown that after 25 or 50 min of elevated cytosolic Ca 2þ , activated eggs readily develop to the blastocyst stage with no sign of apoptosis or necrosis.…”

Section: Introductionmentioning

confidence: 99%

Egg activation is the result of calcium signal summation in the mouse

Tóth¹,

Huneau²,

Banrezes³

et al. 2006

Reproduction

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Repetitive calcium stimuli drive meiotic resumption and pronuclear development during mouse oocyte activation

Cited by 128 publications

References 27 publications

On the transition from the meiotic to mitotic cell cycle during early mouse development

On the transition from the meiotic to mitotic cell cycle during early mouse development

Current Status and Future of Micromanipulation-Assisted Fertilization in Animals and Human.

Egg activation is the result of calcium signal summation in the mouse

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