Reperfusion cardiac arrhythmias and their relation to reperfusion induced cell death

Abstract

Reperfusion cardiac arrhythmias and their relation to reperfusion induced cell deathCitation for published version (APA): van der Weg, K. (2018). Reperfusion cardiac arrhythmias and their relation to reperfusion induced cell death. Proefschriftmaken.nl II Uitgeverij Boxpress. https://doi.org/10.Design by: Bregje Jaspers, ProefschriftOntwerp.nl Printed by: ProefschriftMaken, www.proefschriftmaken.nl © Kirian van der Weg Reperfusion cardiac arrhythmias and their relation to reperfusion induced cell death PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit Maastricht, op gezag van Rector Magnificius, Prof. dr. Rianne M. Letschert, volgens het besluit van het college van Decanen, in het openbaar te verdedigen op vrijdag 21 december 2018 om 12.00 uur door Kirian van der Weg

The Agonist of Inward Rectifier Potassium Channel (I_K1) Attenuates Rat Reperfusion Arrhythmias Linked to CaMKII Signaling

“…Van der Weg, et al proposed that arrhythmias and fatal injury induced by reperfusion are two outcomes proceeded from one process around calcium overload. 38) This viewpoint is highly in concert with our findings. Clinical relevance and prospection: Upregulating Kir2.1 which carries IK1, and consequently maintaining RP and shortening APD might be a promising strategy to attenuate reperfusion arrhythmias caused by Ca 2+ overload and oxidative stress.…”

Reducing reperfusion injury during percutaneous coronary intervention

“…Therefore, reperfusion arrhythmias should serve as a potential bioelectrical marker for fatal reperfusion injury. (6) Accordingly, a reduction in reperfusion arrhythmia in the rhBNP-treated group, as reported by Wang et al, (5) indicates that rhBNP reduces reperfusion injury. Although epicardial coronary artery blood flow seemed to improve based on TIMI frame count, the myocardial blush grade -an angiographic marker of tissue-level reperfusion -was not significantly different in the two different groups.…”

Focus on cardiac arrhythmias and conduction disorders

“…In a review paper the pathophysiological mechanisms of lethal reperfusion injury at the cellular level and reperfusion arrhythmias are discussed in detail. 8 The development of ventricular arrhythmias leading to cardiac arrest is major complication of acute myocardial infarction (MI) responsible for an important prehospital mortality. Analysis of the data of a large clinical acute MI registry at the Vienna general hospital shows that the highest incidence of cardiac arrest is observed in the youngest patients (<45 years) and decreases significantly with increasing age.…”

“…In a review paper the pathophysiological mechanisms of lethal reperfusion injury at the cellular level and reperfusion arrhythmias are discussed in detail. 8…”