Repellent properties of celery, <i>Apium graveolens</i> L., compared with commercial repellents, against mosquitoes under laboratory and field conditions

Tuetun, Benjawan; Choochote, Wej; Kanjanapothi, Duangta; Rattanachanpichai, Eumporn; Chaithong, Udom; Chaiwong, Prasong; Jitpakdi, Atchariya; Tippawangkosol, Pongsri; Riyong, Doungrat; Pitasawat, Benjawan

doi:10.1111/j.1365-3156.2005.01500.x

Cited by 56 publications

(48 citation statements)

References 19 publications

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“…The complete protection of ZPOv against the predominant A. subalbatus and other mosquito vectors, A. gardnerii, C. gelidus, C. tritaeniorhynchus, C. vishnui group, and M. uniformis, was also promising. When compared with other field studies, the complete protective effect of ZPOv against A. subalbatus seems to be comparable to results of hexane-extracted Apium graveolens (Tuetun et al 2005) and exceeds those of the neem oil (37.5%) and ethanol-extracted Curcuma aromatica (89.69%) tested in the studies of Sharma et al (1995) and Pitasawat et al (2003), respectively. In this study, ZPOv and 25% DEETv probably protected against other mosquito species comprising Aedes albopictus, Aedes lineatopennis, Anopheles peditaeniatus, Anopheles tesellatus, C. quinquefasciatus, and Mansonia annulifera, which were only collected from the controls.…”

Section: Discussionmentioning

confidence: 77%

Effectiveness of Zanthoxylum piperitum-derived essential oil as an alternative repellent under laboratory and field applications

et al. 2006

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Recently, there were considerable efforts made to promote the use of environmentally friendly and biodegradable natural insecticides and repellents, particularly from botanical sources. In this study, Zanthoxylum piperitum-derived essential oil isolated by steam distillation was investigated and compared to the standard synthetic repellent, N,N-diethyl-3-methylbenzamide (DEET), for repellency against mosquitoes under laboratory and field conditions. The oil of Z. piperitum alone and also with 5% vanillin added repelled laboratory-reared female Aedes aegypti with the median protection times of 1.5 and 2.5 h, respectively. These repellency times were proven to be significantly lower than those of DEET-based products: 25% DEET and 25% DEET + 5% vanillin demonstrating 3.5 and 5.5 h, respectively. However, when applied under field conditions, Z. piperitum oil + 5% vanillin was found to provide better protection against a wide range of natural mosquito populations than 25% DEET + 5% vanillin. While the product of DEET was effective in reducing bites with 99.7% protection, the protective effect of Z. piperitum oil product appeared complete (100%). It had a protective effect against Aedes gardnerii, Anopheles barbirostris, Armigeres subalbatus, Culex tritaeniorhynchus, Culex gelidus, Culex vishnui group, and Mansonia uniformis. The better repellency against a wide range of field mosquitoes derived from Z. piperitum oil products suggested an advantage of efficacy by providing a broad spectrum of activity. Therefore, Z. piperitum could have potential for use in the development of combined repellents as a natural active ingredient, synergist, or additive to conventional synthetic chemicals, particularly in situations when DEET is ineffective and impractical.

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Section: Discussionmentioning

confidence: 77%

Effectiveness of Zanthoxylum piperitum-derived essential oil as an alternative repellent under laboratory and field applications

et al. 2006

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“…It appeared not to cause dermal irritation or any other adverse effect, either during 6 months of use or in the following 3 months of follow-up. Further studies demonstrated that the ethanolic preparation of hexane-extracted A. graveolens displayed a significant degree of repellency in a dose-dependent manner with vanillin added (Tuetun et al 2005). Ethanolic A. graveolens formulations (10-25 % with and without vanillin) provided 2-5 h protection against female Aedes aegypti.…”

Section: Insect Repellencymentioning

confidence: 98%

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Powanda¹,

Whitehouse

Rainsford

2015

Progress in Drug Research

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Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions. This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India. This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis. CSE can also reduce existing inflammation in rats. CSE has also been shown to provide analgesia in two model systems. CSE, in addition to acting as an analgesic and inflammatory agent, has been shown to protect against and/or reduce gastric irritation caused by NSAIDs, as well as act synergistically with them to reduce inflammation. The CSE was fractionated by organic solvent extractions, then subjected to column chromatography followed by HPLC and was characterized by mass spectrometry. This yielded a purified component that had specific inhibitory effects on Helicobacter pylori but was not active against Campylobacter jejuni or Escherichia coli. Additionally, toxicology studies did not reveal any clear signs of toxicity at doses relevant to human use. Also, unlike many dietary supplements, the available data suggest that CSE does not significantly affect the p450 enzyme systems and thus is less likely to alter the metabolism of drugs the individual may be taking. CSE may be a prototype of a natural product that can be used therapeutically to treat arthritis and other inflammatory diseases.

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“…Unfortunately, there is currently no natural product that can give superior or comparable repellency to that of DEET (Novak and Gerberg 2005). When freshly applied to human skin, citronella or citronella-based repellents are about as effective as the synthetic chemicals in repelling some biting insects but for only approximately 1 h (Rozendaal 1997;Tuetun et al 2005). In addition to advantages such as being selective, easily biodegradable, and doing little or no harm to nontarget organisms, herbal-based products, with a potential source of bioactive chemicals and general use as fragrances and flavoring agents for food and beverages, have been recommended as an alternative source of materials for insect control (Isman 2000;.…”

Section: Introductionmentioning

confidence: 99%

Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes

et al. 2008

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Celery-based products were investigated for chemical composition, skin irritation, and mosquito repellency in comparison to commercial repellents and the standard chemical, N,N-diethyl-3-methylbenzamide (DEET), with a goal to develop a natural alternative to synthetic repellents for protection against mosquitoes. Chemical identification by gas chromatography coupled with mass spectrometry discovered that the major constituents of Apium graveolens hexane extract (AHE) were 3-n-butyl-tetrahydrophthalide (92.48%), followed by 5.10% beta-selinene and 0.68% gamma-selinene. Evaluation of skin irritation in 27 human volunteers revealed no irritant potential from 25% ethanolic AHE solution. Laboratory investigated repellent against female Aedes aegypti mosquitoes demonstrated that G10 formula, the best AHE-developed product, provided remarkable repellency with a median protection time of 4.5 h (4.5-5 h), which was greater than that of ethanolic DEET solution (25% DEET, 3.5 h) and comparable to that of the best commercial repellent, Insect Block 28 (28.5% DEET, 4.5 h). According to significantly promising results, including highly effective repellency and no potential skin irritation or other side effects, the G10 formula is a worthwhile product that has the promise of being developed for commercialized registration. This developed AHE product could be an acceptable and affordable alternative to conventional synthetic chemicals in preventing mosquito bites, and in turn, helping to interrupt mosquito-borne disease transmission.

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Repellent properties of celery, Apium graveolens L., compared with commercial repellents, against mosquitoes under laboratory and field conditions

Cited by 56 publications

References 19 publications

Effectiveness of Zanthoxylum piperitum-derived essential oil as an alternative repellent under laboratory and field applications

Effectiveness of Zanthoxylum piperitum-derived essential oil as an alternative repellent under laboratory and field applications

Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes

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