Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities

Abstract

Celery preparations have been used extensively for several millennia as natural therapies for acute and chronic painful or inflammatory conditions. This chapter reviews some of the biological and chemical properties of various celery preparations that have been used as natural remedies. Many of these have varying activities and product qualities. A fully standardized celery preparation has been prepared known as an alcoholic extract of the seeds of a plant source derived from northern India. This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis. CSE can also reduce existing inflammation in rats. CSE has also been shown to provide analgesia in two model systems. CSE, in addition to acting as an analgesic and inflammatory agent, has been shown to protect against and/or reduce gastric irritation caused by NSAIDs, as well as act synergistically with them to reduce inflammation. The CSE was fractionated by organic solvent extractions, then subjected to column chromatography followed by HPLC and was characterized by mass spectrometry. This yielded a purified component that had specific inhibitory effects on Helicobacter pylori but was not active against Campylobacter jejuni or Escherichia coli. Additionally, toxicology studies did not reveal any clear signs of toxicity at doses relevant to human use. Also, unlike many dietary supplements, the available data suggest that CSE does not significantly affect the p450 enzyme systems and thus is less likely to alter the metabolism of drugs the individual may be taking. CSE may be a prototype of a natural product that can be used therapeutically to treat arthritis and other inflammatory diseases.

Activity of Aloe vera, Apium graveolens and Sauropus androgynus Alcoholic Extracts against Methicillin-Resistant Staphylococcus aureus.

“…It proves that AG is potential as an herbal remedy. The antioxidants insides the AG are utilised as the antiparasite (Kumar et al, 2014), antitumour (Danciu et al, 2018) and antibacterial agents (Powanda et al, 2015). The other herb is SA which contains several active constituents such as glycoside, flavonoid, and alkaloid that potential as the antitoxic and antioxidant (Prabhu et al, 2015).…”

Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells

“…Moreover, the extract has been shown to inhibit the proliferation and migration of MCF7 breast cancer cell line [ 19 ]. Celery seeds extracts have been described for their antioxidant, antimicrobial, antiarthritic, and antiulcer potential [ 20 , 21 ]. The group of Mansi et al have also found that the extract can induce a hypolipidemic effect in rats [ 22 ].…”

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“…[32] Similarly, Swertiamarin attenuates inflammation mediators via modulating NFκB/IkB and JAK STAT3 transcription factors in adjuvantinduced arthritis, [33] Celery seeds also show anti-arthritic activity. [34] Tinospora cordifolia, [35] Terminalia chebula Retz, [36] and Ajuga bracteosa Wall ex Benth [37] and Lakshadi Guggul showed strong anti-arthritic potential in albino rats [ Table 1]. [38] A regular treatment significantly reduces both the arthritic index (AI) and the CIA incidence.…”