Repellent Action of Neem (&lt;i&gt;Azadirachta indica&lt;/i&gt;) Seed Oil Cream against &lt;i&gt;Anopheles&lt;/i&gt; Gambiae Mosquitoes

Aremu, OI; Femi-Oyewo, Mbang N.; Popoola, K. O. K.

doi:10.4314/afrrev.v3i3.47510

Cited by 8 publications

(8 citation statements)

References 3 publications

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“…By adopting the method of [ 9 ], hexane was used as the solvent for the extraction of the neem oil. Using a seed to solvent ratio of 1:10, the seed was allowed to soak in the solvent at room temperature for ten days.…”

Section: Methodsmentioning

confidence: 99%

Chemical Composition and In Vitro Evaluation of the Mosquito (Anopheles) Repellent Property of Neem (Azadirachta indica) Seed Oil

Aidoo

Kuntworbe

Owusu

et al. 2021

Journal of Tropical Medicine

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As one of the killer diseases in the world, malaria contributes to child mortality and global death annually. As a result, many reactive mechanisms have evolved to control and repel mosquitoes. The use of synthetic mosquito repellents with N,N-Diethyl-meta-toluamide (DEET) is one of the popular interventions despite its dermatological limitations such as skin irritations. Ethnobotanical reviews have identified that the adoption of natural repellents promises high repellence on mosquitoes with minimal side effects compared with synthetic ones. However, this has received little attention in modern pharmaceutical literature. This research is focused on the formulation of a natural mosquito repellent from the oil extracted from Azadirachta indica (A. Juss). The oil cream was formulated in concentrations of 10% v / w , 12.5% v / w , 15% v / w , 17.5% v / w , and 20% v / w using an in vitro evaluation approach. Pharmacopoeia characteristics of the cream such as pH, viscosity, spreadability, and organoleptic properties were carried out to verify acidity, permeation, and flow properties of the formulated cream. The spreadability rate was inversely proportional to the concentration of the cream in terms of oil content falling from 1.24 gm/s to 0.84 gm/s from concentrations 10% v / w to 20% v / w correspondingly. Skin irritation tests, however, indicated traces of irritation at 20% v / w . Repellency properties of the cream revealed a lasting effect on the mosquitoes, although this was dependent on concentration levels. Formulations of 17.5% v / w and 20% v / w neem seed oil cream had an equal repellency effect of 87.5%, whereas the synthetic repellent had a repellency of 75% within a justifiable time frame for all the formulations. This work shows that plant-based mosquito repellents promise a healthier approach in controlling mosquito bites, protecting the skin, and preventing malaria.

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Section: Methodsmentioning

confidence: 99%

Chemical Composition and In Vitro Evaluation of the Mosquito (Anopheles) Repellent Property of Neem (Azadirachta indica) Seed Oil

Aidoo

Kuntworbe

Owusu

et al. 2021

Journal of Tropical Medicine

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“…Neem seed oil cream has proven to be very valuable as insect repellent particularly at higher concentrations of 7.5% and 10.0% w/w. This can be considered as an alternative to conventional pesticides that have been associated with certain adverse effects as earlier mentioned [10]. Again, Azadirachta indica, Schinnus molle, and Phytolacca odecandra extracts were found to produce high percentage larval mortality (>95%) against Fall Armyworm (FAW) after 72 h application [11].…”

Section: Introductionmentioning

confidence: 90%

The bioactivities of the neem (seeds and leaves) against Callosobruchus maculatus on a Vigna Subterranean L.

2019

Prog. Chem. Biochem. Res.

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This research reports the novel bioactivities of neem leaves powder, neem leaves concentrate, neem seeds powder and neem seeds oil against the weevil (Callosobruchus maculatus) on bambara groundnut. The leaves were ground, crushed and subjected to ethanol to get the concentrate. While the seeds were dried under shade for one week, ground into fine particles. Cold bulk extraction was then used to obtain the neem seeds oil. The mortality count of Callosobruchus maculatus (C. maculatus) was studied by exposing the weevil to neem treated bambara groundnut at different days under laboratory condition. The neem dosage were 0.0, 0.1, 0.5 1.0 g/10 g of bambara groundnut. The percentage weight loss and seed damage were also determined at the end. The results indicated that neem seeds oil and neem leaves concentrate provided effective and comparable mortality counts against the C. maculatus. Again the neem powder (seeds and leaves) mortality counts were also comparable, but were less effective against the weevils as compared to the neem oil and concentrate at least for the first two days. Therefore, these neem materials could be used as biopesticides at the dose of 0.1 per 10 g to prevent C. maculatus attack on bambara groundnut during storage. This will reduce the usage of synthetic pesticides, thereby preventing their adverse residual effects on human and the environment.

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“…In the study areas, Azadirachta indica Leaves and crushed seeds are used to chase mosquito away. In different studies [32,33] the fruit and bark extract of A. indica exhibited repellent activity at p<0.05 and the seed kernel extract at p<0.01 significance levels for two different mosquito Culex and female Anopheles respectively. The most prominent constituent of Neem is azadirachtin, which has been established as a pivotal insecticidal ingredient acting as an anti feedant, repellent, and repugnant agent and induces sterility in insects by preventing oviposition and interrupting sperm production in males [34].…”

Section: Scent or Fumes From The Fresh Twigsmentioning

confidence: 99%

Integrating land use plans in malaria control with mosquito repellent plants in homesteads in Tanzania

Otieno¹,

kweyunga²

2022

Int. J. Front. Biol. Pharm. Res.

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Apart from the conventional malaria control schemes over the decades, there is gradual growing interest in multipurpose plant species with repellence activity against mosquitoes and other nuisance organisms in the homesteads. Ethnobotanical study in selected districts in Tanzania employed statistical Use Value (UV) model to rank and recommend priority repellent plants used by local communities. The five top ranking repellent plant species according to UV analysis were Ocimum basilicum, Hyptis suaveolense, Azadirachta indica, Cocos nucifera and and Schinus mole. Qualitative assessment of repellence activity for selected plants was performed in different forms such as smoking, infusion and natural scent to validate repellence activity. Basic soil parameters viz. Ca, Mg, Na, P, N, organic matter, cation exchange capacity and pH from the plants habitats were determined to facilitate transplanting of recommended plants in new environments. Community perception on planting non-traditional crops on the home yards was assessed to aid in developing plans for integrating repellent plants among other land use priorities on the homesteads. The envisaged long term impact is creation of microclimate complex at rural homesteads simultaneously capable of providing diverse domestic needed plant products while controlling mosquitoes and other non-friendly organisms from the homesteads.

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Repellent Action of Neem (<i>Azadirachta indica</i>) Seed Oil Cream against <i>Anopheles</i> Gambiae Mosquitoes

Cited by 8 publications

References 3 publications

Chemical Composition and In Vitro Evaluation of the Mosquito (Anopheles) Repellent Property of Neem (Azadirachta indica) Seed Oil

Chemical Composition and In Vitro Evaluation of the Mosquito (Anopheles) Repellent Property of Neem (Azadirachta indica) Seed Oil

The bioactivities of the neem (seeds and leaves) against Callosobruchus maculatus on a Vigna Subterranean L.

Integrating land use plans in malaria control with mosquito repellent plants in homesteads in Tanzania

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