Repeated short-term daily exercise ameliorates oxidative cerebral damage and the resultant motor dysfunction after transient ischemia in rats

Hamakawa, Michiru; Ishida, Atsushi; Tamakoshi, Keigo; Shimada, Haruka; Nakashima, Hiroyuki; Noguchi, Taiji; Toyokuni, Shinya; Ishida, Kenji

doi:10.3164/jcbn.12-72

Cited by 16 publications

(12 citation statements)

References 30 publications

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“…Regarding RT, the studies have shown that low to moderate RT intensity improves the activity of antioxidant enzymes (increase in SOD, GSH, GPX, and CAT levels, while a reduction in MDA levels) in the skeletal muscle, which is consistent with the results of the present study (24). The findings of the present study are consistent with the study of Hamakawa et al (25). It seems that adjusting the levels of antioxidant enzymes due to exercise depends on the high amount of oxidative stress in the skeletal muscle (25).…”

Section: Discussionsupporting

confidence: 93%

“…The findings of the present study are consistent with the study of Hamakawa et al (25). It seems that adjusting the levels of antioxidant enzymes due to exercise depends on the high amount of oxidative stress in the skeletal muscle (25). Possibly, the increase in these enzymes following exercise will result in a further increase in lipid peroxidation and free radical production.…”

Section: Discussionsupporting

confidence: 93%

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The Effects of Resistance Training and Berberine Chloride Supplementation on Oxidative Stress Markers in the Cerebellum Tissue of Diazinon-Poisoned Rats

Ezabadi

Peeri

Azarbayjani

et al. 2019

Middle East J Rehabil Health Stud

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Background: Diazinon is an insecticide from the organophosphorus group, which can increase the oxidative stress in the body. It has been established that training and antioxidant supplementation can improve oxidative stress system by decreasing malondialdehyde (MDA); meanwhile, increasing the activities of antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT). Objectives: The aim of this study was to investigate the effect of resistance training (RT) and berberine chloride (BC) supplementation on oxidative stress indices in the cerebellum tissue of diazinon-poisoned rats. Methods: Fifty-six Wistar rats were divided into seven groups (n = 8), including resistance training (RT) (each session 2 sets of 6 repetitions, each one required 8 to 12 active movements with intensity of 10%-50% of body weight, 3 sessions per week), BC2 (BC: 2 mg/kg), BC15 (BC: 15 mg/kg), RT + BC2, RT + BC15, diazinon, and control. MDA, SOD, and CAT were measured in the cerebellum tissue. Results: RT and BC significantly reduced MDA protein levels (P < 0.01), while increased SOD protein levels (P < 0.01) and CAT protein levels (P < 0.01) in the cerebellum tissue of diazinon-poisoned rats; RT with BC had interactive effects on decreasing MDA (P < 0.01), while increasing SOD (P < 0.01) and CAT protein levels (P < 0.01). Also, the consumption of 15 mg/kg BC rather than 2 mg/kg BC significantly increased SOD protein levels (P = 0.02). Conclusions: It seems that RT combination with BC has Interactive effects on the improvement of oxidative stress markers in the cerebellum tissue of diazinon-poisoned rats.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

The Effects of Resistance Training and Berberine Chloride Supplementation on Oxidative Stress Markers in the Cerebellum Tissue of Diazinon-Poisoned Rats

Ezabadi

Peeri

Azarbayjani

et al. 2019

Middle East J Rehabil Health Stud

View full text Add to dashboard Cite

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“…In line with this, preclinical studies have demonstrated that prestroke preconditioning with PA in patients with cerebral ischemia reduces neuronal apoptosis, oxidative damage, inflammatory response, blood-brain-barrier dysfunction, and capillary dysfunction [14,15,24,25,26]. Our main hypothesis was that recent prestroke PA alone could protect the ischemic brain and reduce acute cerebral infarct growth, final infarct size and thus improve functional outcomes.…”

Section: Discussionsupporting

confidence: 57%

High Prestroke Physical Activity Is Associated with Reduced Infarct Growth in Acute Ischemic Stroke Patients Treated with Intravenous tPA and Randomized to Remote Ischemic Perconditioning

et al. 2017

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Background: A high prestroke physical activity (PA) level is associated with reduced stroke rate, stroke mortality, better functional outcome, and possible neuroprotective abilities. The aim of the present study was to examine the possible neuroprotective effect of prestroke PA on 24-h cerebral infarct growth in a cohort of acute ischemic stroke patients treated with intravenous tPA and randomized to remote ischemic perconditioning. Methods: In this predefined subanalysis, data from a randomized clinical trial investigating the effect of remote ischemic perconditioning (RIPerC) on AIS was used. Prestroke (7 days before admission) PA was quantified using the PA Scale for the Elderly (PASE) questionnaire at baseline. Infarct growth was evaluated using MRI (acute, 24-h, and 1-month). Results: PASE scores were obtained from 102 of 153 (67%) patients with a median (interquartile range) age of 66 (58-73) years. A high prestroke PA level correlated significantly with reduced acute infarct growth (24 h) in the linear regression model (4th quartile prestroke PA level compared with the 1st quartile), β_{4th quartile} = -0.82 (95% CI -1.54 to -0.10). However, the effect of prestroke PA was present mainly in patients randomized to RIPerC, β_{4th quartile} = -1.14 (95% CI -2.04 to -0.25). In patients randomized to RIPerC, prestroke PA was a predictor of final infarct size (1-month infarct volume), β_{4th quartile} = -1.78 (95% CI -3.15 to -0.41). Conclusion: In AIS patients treated with RIPerC, as add-on to intravenous thrombolysis, the level of PA the week before the stroke was associated with decreased 24-h infarct growth and final infarct size. These results are highly encouraging and stress the need for further exploration of the potentially protective effects of both PA and remote ischemic conditioning.

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“…The results showed that exercise reduced apoptosis and cerebral infarction (21). Hamakawa et al showed that three weeks of pre-training along with exercise reduced oxidative stress markers and increased the activity of antioxidant enzymes, which was associated with reduced infarct volume and improved neurological functional outcomes after ischemic damage (22). Finally, it can be concluded that exercise activity in the present study was able to exert its protective effects by altering the expression of the target genes.…”

Section: Discussionsupporting

confidence: 56%

The Effect of Two Types of Training Programs on the Expression of TrkB, Bax and Bcl-2 Genes in Male Rats After Induction of Cerebral Ischemia

2020

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Background: Physical activity and dynamic lifestyle play an important role in the prevention and treatment of some common neurological diseases. One valuable approach to increasing health and reducing brain damage is to perform an exercise and physical activity. Objectives: The aim of the present study was to investigate the effect of exercise pre-training on the intervening factors and complications of cerebral ischemia. Methods: In this study, forty Wistar rats were randomly divided into four groups, including (1) endurance training, (2) endurancecognitive training, (3) ischemia, and (4) control. The training was performed for 3 weeks. After the last training session, the rats had to undergo cerebral ischemia. The ischemia was induced by occlusion of both common carotid arteries for 30 min. Real-time PCR method was used to measure the expression level of TrkB, Bax, and Bcl-2 genes. Results: The levels of TrkB gene expression were significantly increased in the endurance training and endurance-cognitive training groups compared to the ischemia and control groups (P < 0.05). There was a significant increase in the levels of Bcl-2 gene expression in the endurance training group compared to the ischemia group as well as the endurance-cognitive group compared to the ischemia and control groups (P < 0.05). Also, the levels of Bax gene expression in the endurance training and endurance-cognitive groups were significantly lower than the control group (P < 0.05). Conclusions: This study showed that exercise as a preconditioning stimulus has neuroprotective effects against cerebral ischemia.

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Repeated short-term daily exercise ameliorates oxidative cerebral damage and the resultant motor dysfunction after transient ischemia in rats

Cited by 16 publications

References 30 publications

The Effects of Resistance Training and Berberine Chloride Supplementation on Oxidative Stress Markers in the Cerebellum Tissue of Diazinon-Poisoned Rats

The Effects of Resistance Training and Berberine Chloride Supplementation on Oxidative Stress Markers in the Cerebellum Tissue of Diazinon-Poisoned Rats

High Prestroke Physical Activity Is Associated with Reduced Infarct Growth in Acute Ischemic Stroke Patients Treated with Intravenous tPA and Randomized to Remote Ischemic Perconditioning

The Effect of Two Types of Training Programs on the Expression of TrkB, Bax and Bcl-2 Genes in Male Rats After Induction of Cerebral Ischemia

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