Repeated Oral Administration of a Squeezed Ginger (<i>Zingiber officinale</i>) Extract Augmented the Serum Corticosterone Level and Had Anti-Inflammatory Properties

Ueda, Hiroshi; Ippoushi, Katsunari; Takeuchi, Atsuko

doi:10.1271/bbb.100456

Cited by 33 publications

(15 citation statements)

References 31 publications

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“…It was reported in a previous study that the oral administration of squeezed ginger augmented the production of IL-6 in mouse leukemic monocytes (Ueda et al, 2010). In another study, it was reported that IL-6 expression increased by a dosedependent manner due to silymarin administration (Johnson et al, 2003).…”

Section: Discussionmentioning

confidence: 95%

Effect of methotrexate combined with ginger, silymarin or propolis on the mRNA expression levels of cytochrome P450 oxidoreductase (POR), caspase 3 (CASP-3) and interlukin 6 (IL-6)

Hassan¹,

Ismail²,

Mohamed³

2015

Afr. J. Biotechnol.

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The present study was performed to evaluate the effect of three natural antioxidants on the adverse effect of methotrexate (MTX) in normal liver cells. TaqMan RT-PCR technology was used to estimate the mRNA expression levels for three genes after rats injection with a single dose of 20 mg/kg b.w MTX or the same MTX dose combined with ginger, silymarin or propolis oral administration. The doses of ginger, silymarin or propolis were similar (200 mg/kg b.w) and were daily administrated to rats for 21 days before MTX injection and four days after MTX injection. The three genes were: cytochrome P450 oxidoreductase (POR) that encodes POR enzyme, caspase 3 (CASP-3) that encodes CASP-3 enzyme and interlukin 6 (IL-6) that encodes IL-6 pro-inflammatory cytokine. Results indicate that the used MTX single dose of 20 mg/kg b.w did not significantly affect POR mRNA expression level in rat liver. Moreover the administration of ginger, silymarin or propolis with MTX did not significantly increase or decrease POR mRNA expression level. Results also reveal insignificant increase in CASP-3 mRNA expression level after MTX injection and also after administration of ginger or propolis with MTX. The administration of silymarin with MTX significantly increased the CASP-3 mRNA expression level. IL-6 mRNA expression level was insignificantly upregulated after injection with MTX and also after administration of silymarin with MTX whereas a significantly upregulation in the IL-6 mRNA expression level was reported after administration of ginger or propolis with MTX.

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Section: Discussionmentioning

confidence: 95%

Effect of methotrexate combined with ginger, silymarin or propolis on the mRNA expression levels of cytochrome P450 oxidoreductase (POR), caspase 3 (CASP-3) and interlukin 6 (IL-6)

Hassan¹,

Ismail²,

Mohamed³

2015

Afr. J. Biotechnol.

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“…Naderi et al conducted a 12-week clinical trial to investigate the effects of ginger supplementation on nitric oxide and CRP in elderly knee osteoarthritis patients and reported that ginger powder supplementation at a dose of 1 g/d can reduce inflammatory markers in patients with knee osteoarthritis (5), which is in line with the findings of a study by Rahimlou et al (35). However, one study reported that after oral administration of 100–1,000 mg/ml squeezed ginger extract in mice, the production of inflammatory markers increased (16). …”

Section: Discussionmentioning

confidence: 99%

“…Imani et al indicated that daily administration of 1,000 mg ginger reduces serum fasting glucose (15). However, a few studies have reported an increase (16) or a non-significant (15) effect of ginger supplementation on inflammatory markers. Thus, inconsistent findings have been reported in this field.…”

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confidence: 99%

The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis

Mazidi

Gao

Rezaie

et al. 2016

Food & Nutrition Research

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AimTo undertake a systematic review and meta-analysis of prospective studies to determine the effect of ginger supplementation on serum C-reactive protein (CRP), lipid profile, and glycaemia.MethodPubMed-MEDLINE, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until July 2016) to identify prospective studies evaluating the impact of ginger supplementation on serum CRP. Random-effects model meta-analysis was used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. Heterogeneity was quantitatively assessed using the I2 index. Systematic review registration: CRD42016035973.ResultsFrom a total of 265 entries identified via searches, 9 studies were included in the final selection. The meta-analysis indicated a significant reduction in serum CRP concentrations following ginger supplementation [weighted mean difference (WMD)−0.84 mg/L (95% CI −1.38 to −0.31, I2 56.3%)]. The WMD for fasting blood glucose and HbA1c was −1.35 mg/dl (95% CI −2.04 to −0.58, I2 12.1%) and −1.01 (95% CI −1.28 to −0.72, I2 9.4%), respectively. Moreover, high-density lipoprotein and triglyceride significantly improved after ginger administration [1.16 mg/dl (95% CI 0.52 to 1.08, I2 12.3%) and −1.63 mg/dl (95% CI −3.10 to −0.17, I2 8.1%), respectively]. These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in serum CRP levels were independent of the dosage of ginger supplementation (slope −0.20; 95% CI −0.95 to 0.55; p=0.60).ConclusionsThis meta-analysis suggests that ginger supplementation significantly reduces serum CRP and improves glycaemia indexes and lipid profile. Randomized control trials with larger sample size and with a longer-term follow-up period should be considered for future investigations.

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“…The oral administration of the squeezed ginger extract had a dual effect on TNF-α synthesis in mice, in peritoneal cells: ZO extract initially augmented it, but after repeated admnistrations decreased it [95]. Also it augmented the serum corticosterone level, and this may contribute to the anti-inflammatory effect of ZO.…”

Section: Zingiber Officinalis Fam Zingiberaceaementioning

confidence: 93%

“…ZO is thought to have anti-inflammatory effects, possibly by inhibiting COX-1, COX-2 and LOX [92][93][94]. Nevertheless, the squeezed ginger extract paradoxically increased the synthesis of proinflammatory cytokines (TNF-α, IL-6, and monocyte chemotactic protein-1) in RAW 264 cell culture [95].…”

Section: Zingiber Officinalis Fam Zingiberaceaementioning

confidence: 99%

Phytomedicine in Joint Disorders

Dragoș

Gîlcă

Găman

et al. 2017

Preprint

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Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from painkillers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. Used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower rate of adverse events and an efficiency frequently comparable with that of conventional drugs. Nevertheless, their mechanism of action is in many cases elusive and/or uncertain. Even many of them have been proved effective in studies done in vitro or on animal models, there is a scarcity of human clinical evidence. The purpose of this review is to summarise the available scientific information on these joint-friendly medicinal plants, which have been already tested in human studies: Arnica montana, Boswellia spp., Curcuma spp., Equisetum arvense, Harpagophytum procumbens, Salix spp., Sesamum indicum, Symphytum officinalis, Zingiber officinalis, Panax notoginseng, Whitania somnifera.

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Repeated Oral Administration of a Squeezed Ginger (Zingiber officinale) Extract Augmented the Serum Corticosterone Level and Had Anti-Inflammatory Properties

Cited by 33 publications

References 31 publications

Effect of methotrexate combined with ginger, silymarin or propolis on the mRNA expression levels of cytochrome P450 oxidoreductase (POR), caspase 3 (CASP-3) and interlukin 6 (IL-6)

Effect of methotrexate combined with ginger, silymarin or propolis on the mRNA expression levels of cytochrome P450 oxidoreductase (POR), caspase 3 (CASP-3) and interlukin 6 (IL-6)

The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis

Phytomedicine in Joint Disorders

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