Repeated measurements of serum concentrations of TNF-alpha, interleukin-6 and interleukin-10 in the evaluation of internal carotid artery stenosis progression

Puz, Przemysław; Lasek–Bal, Anetta

doi:10.1016/j.atherosclerosis.2017.06.008

Cited by 23 publications

(11 citation statements)

References 23 publications

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“…In our study patients who underwent surgical repair of carotid artery had significantly higher serum levels of IL-10 when compared to control subjects. Our findings are in line with recent evidence of higher levels of IL-6 and IL-10 in patients with progressive carotid sclerosis (33). Moreover, in this study IL-6 and IL-10 were found to be independent variables for the unfavorable dynamics of changes in the morphology of atherosclerotic carotid plaques.…”

Section: Discussionsupporting

confidence: 93%

Circulating IL-10 Levels in Carotid Artery Disease

Stanković

Ljujić

Radak³

et al. 2019

Serbian Journal of Experimental and Clinical Research

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Carotid atherosclerosis may be associated with neurosymptoms including cerebral infarction. IL-10 exerts atheroprotective eff ects, but its role in carotid disease is not fully defi ned. We aimed to investigate serum IL-10 levels in patients undergoing endarterectomy and their relation to the degree of carotid stenosis, plaque types and neurosymptoms.Two hundred consecutive patients with atherosclerotic carotid stenosis and 29 healthy controls were enrolled in this study. Plaque types were classifi ed according to AHA criteria. Serum IL-10 levels were determined by ELISA.Patients undergoing endarterectomy had signifi cantly higher circulating IL-10 levels (18.7 ± 3.2 pg/ml) in comparison with healthy controls (7.2 ± 1.8pg/ml; P =0.0001) and IL-10 has good discriminatory effi cacy between these two groups (ROC curve, AUC = 0.723, P=0.0001). Patients with < 70% and those with > 70% of carotid stenosis did not diff er in terms of age, sex, cardiovascular risk factors except hypertension, neurosymptoms and AHA plaque types. Circulating IL-10 levels diff ered signifi cantly among patients with diff erent carotid plaque types (P = 0.002). Patients with uncomplicated plaques had signifi cantly higher serum levels of IL-10 (23.0 ± 6.1 pg/ml) compared to those with complicated plaques (13.0 ±1.4 pg/ml, P=0.035) and IL-10 can diff erentiate patients between these two groups (ROC curve, AUC = 0.413, P= 0.035).Our fi ndings reveal an important role for IL-10 in carotid atherosclerosis. IL-10 might be a potential biomarker in discriminating patients with carotid disease from healthy controls. Decreased serum levels of IL-10 are related to complicated carotid plaques.

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Section: Discussionsupporting

confidence: 93%

Circulating IL-10 Levels in Carotid Artery Disease

Stanković

Ljujić

Radak³

et al. 2019

Serbian Journal of Experimental and Clinical Research

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“…The population-based study conducted by Eltoft et al [40] demonstrated IL-6 as a predictor of progressive atherosclerotic disease. The IL-6 level positively correlated with the presence of unstable plaque, dynamics of changes in atherosclerotic plaque morphology in the internal carotid artery [41], and the degree of carotid stenosis [41,42]. Nonetheless, current studies differ as to whether there is an association between IL-6 and carotid IMC thickness, which is the parameter used to detect and monitor early atherosclerotic lesions [43].…”

Section: Discussionmentioning

confidence: 92%

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

et al. 2019

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Background: Over the last two decades, many studies have investigated the association between interleukin 6 (IL-6) and pathogenesis and progression of coronary artery disease (CAD). Patients with CAD manifested at a young age are a particularly interesting group. They differ from older patients, not only in terms of the severity of coronary artery atherosclerosis, but also risk factor profiles, short- and long-term prognosis after myocardial infarction (MI). The role of IL-6 in younger patients with CAD is less well-known. Therefore, our study aimed to analyze the relationship between IL-6 level and other inflammations, atherosclerosis, and cardiac function parameters in early onset CAD patients. Methods: The study covered 100 patients with early onset CAD and a group of 50 healthy participants. Plasma levels of IL-6 and basic biochemical parameters, anthropometric, echocardiographic, and arteries Doppler ultrasound measurements were performed. Results: We did not observe a significant difference in IL-6 concentration in plasma between patients with early onset CAD and a control group, but IL-6 level was negatively correlated with echocardiographic measurements of ascending aorta diameter, left ventricular shortening fraction, and right ventricular end-diastolic diameter in our patients. Conclusions: In patients with early onset CAD, plasma IL-6 level is associated with other inflammation parameters and with cardiac function, potentially contributing to right ventricular remodeling and left ventricular systolic dysfunction. This suggests possible prognostic benefits of long-time observation of IL-6 level after the acute coronary syndrome.

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“…MS, the most common cause of neurological disability among young adults, is generally believed to be a chronic inflammatory demyelinating disease, which has a median prevalence of 80/100,000 people in Europe. Inflammation in autoimmune diseases can damage the normal physiological function of the endothelium, accelerate the process of atherosclerosis, and increase the risks of cerebrovascular diseases, particularly ischemic stroke [21–23]. Furthermore, the fatty myelin sheaths around the axons are damaged in the CNS, leading to demyelination, remyelination, axonal loss, gliosis and neurodegeneration [3].…”

Section: Discussionmentioning

confidence: 99%

Multiple sclerosis and stroke: a systematic review and meta-analysis

Hong

Tang

et al. 2019

BMC Neurol

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Background Multiple sclerosis (MS) and stroke are two common causes of death and disability worldwide. The relationship between these two diseases remains unclear. Effective early preventative measures and treatments are available to reduce the morbidity and mortality of acute stroke. The objectives of our systematic review are to estimate the risk of stroke in patients with MS and to collate related studies to draw preliminary conclusions that may improve clinical practice. Method Relevant studies were systematically searched in MEDLINE, Embase, the Chinese Biomedical Literature Database (CBM), the China National Knowledge Infrastructure and the VIP database of Chinese periodicals from January 1983 to May 2017, with no restrictions on language. Patients included in this review were adults who suffered from MS. Review Manager 5.3 software program was used to pool data and calculate the risk ratio (RR) and its 95% confidence interval (CI). We also performed heterogeneity and sensitivity analyses and evaluated bias in the meta-analysis. Results Nine studies including more than 380,000 participants that met our inclusion criteria were incorporated into the meta-analysis. During different follow-up periods, patients with MS had an increased risk of any type of stroke [RR = 3.48, 95% CI (1.59, 7.64), P = 0.002 for 1 year; RR = 2.45, 95% CI (1.90, 3.16), P < 0.00001 for 10–13 years]. The total prevalence of stroke (any type) in patients with MS exceeded expectations compared to different groups [Comparing with general veteran: RR = 2, 95% CI (1.19, 3.38), P = 0.009. Comparing with general population: RR = 2.93, 95% CI (1.13, 7.62), P = 0.03]. Furthermore, ischemic stroke was particularly more common in the MS population than in people without MS [RR = 6.09, 95% CI (3.44, 10.77), P < 0.00001]. Conclusion Compared with the general population, people with MS have an increased risk of developing any type of stroke and ischemic stroke in particular. Consistent results were obtained from patients of different sexes and age groups. Preventative measures and treatments should be administered at earlier time points to improve patient outcomes. Electronic supplementary material The online version of this article (10.1186/s12883-019-1366-7) contains supplementary material, which is available to authorized users.

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Repeated measurements of serum concentrations of TNF-alpha, interleukin-6 and interleukin-10 in the evaluation of internal carotid artery stenosis progression

Cited by 23 publications

References 23 publications

Circulating IL-10 Levels in Carotid Artery Disease

Circulating IL-10 Levels in Carotid Artery Disease

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

Multiple sclerosis and stroke: a systematic review and meta-analysis

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