Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

Pauli, Natalia; Puchałowicz, Kamila; Kuligowska, Agnieszka; Krzystolik, Andrzej; Dziedziejko, Violetta; Safranow, Krzysztof; Chlubek, Dariusz; Rać, Monika

doi:10.3390/diagnostics9040189

Cited by 12 publications

(13 citation statements)

References 58 publications

(87 reference statements)

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“…Disturbances in IL-6 secretion resulting in high serum plasma levels and persistence of its proinflammatory activity leads to the conversion of acute inflammatory response to chronic inflammatory process ( 33 ). High serum levels of IL-6 have been recorded in rheumatoid arthritis, systemic juvenile idiopathic arthritis, systemic lupus erythematosus, psoriasis, Crohn disease and ankylosing spondylitis ( 22 , 34 ). Tocilizumab, a monoclonal humanized IgG1 class antibody which inhibits IL-6 binding to its soluble and transmembrane receptors was approved in over 100 countries for rheumatoid arthritis treatment ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

High serum level of interleukin‑6 is linked with dyslipidemia in oral lichen planus

et al. 2021

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Oral lichen planus (OLP) is a complex chronic inflammatory disorder in which autocytotoxic CD8 + T cells, locally present in the affected tissue, induce basal keratinocyte apoptosis, through the release of several cytokines, such as interleukin-6 (IL-6). IL-6 is a proinflammatory cytokine that is related to alterations in lipid metabolism in psoriasis patients. Impaired lipid metabolism together with high serum levels of triglycerides have been found in association with OLP. However, the correlation between serum levels of IL-6 and dyslipidemia has not yet been studied in this disorder. The present study aimed to demonstrate the association between OLP, systemic inflammation through increased release of inflammation mediators such as IL-6 and alteration of lipid metabolism, in order to support the concept of OLP as a marker of systemic inflammation and a potential risk factor of cardiovascular morbidities. For this purpose, we designed a case-control study using a cohort of 18 patients with different clinical forms of OLP compared with 18 control group patients with other oral conditions, to identify a potential correlation between serum levels of IL-6 and serum lipid levels. High plasma serum levels of IL-6 were found to be correlated with cholesterol, high density lipoprotein cholesterol and triglyceride serum levels in the patients with OLP. There was a significant association between erosive and atrophic clinical forms of OLP and the pathological serum values of IL-6 and triglycerides, respectively, making these two parameters good predictive factors of the clinical form of OLP. Further studies of other biomarkers of systemic inflammation using larger cohorts of OLP patients are necessary in order to consider LP as a marker of systemic inflammation and to support the screening of these patients for lipid metabolism changes and treatment with specific antagonists in order to prevent cardiovascular events.

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Section: Discussionmentioning

confidence: 99%

High serum level of interleukin‑6 is linked with dyslipidemia in oral lichen planus

et al. 2021

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“…Выявленные нами ассоциации толщины КИМ сонных артерий с уровнями скорости оседания эритроцитов и ИЛ-6 соответствуют результатам других работ [39][40][41]. Хорошо изучено влияние воспалительных маркеров на активацию иммунных клеток и развитие эндотелиального повреждения, лежащего в основе атеросклеротического процесса [42,43], выявлена экспрессия ИЛ-6 и его рецепторов в зонах сосудистого русла, наиболее подверженных атеросклеротическому поражению [44].…”

Section: Discussionunclassified

Application of cardiovascular risk scales to identify carotid atherosclerosis in patients with rheumatoid arthritis

Gerasimova

Владимировна²,

Попкова

et al. 2021

Terapevticheskii arkhiv

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Aim. To evaluate the cardiovascular risk (CVR) and analyze its relationship with detection of early carotid artery atherosclerotic lesion in patients with rheumatoid arthritis (RA). Materials and methods. One hundred and nine RA patients aged 45 to 60 without established cardiovascular diseases (CVD) were included in the study. The median age was 52 [48; 54] years, duration of RA was 120 [36; 204] months, DAS28 was 4.7 [3.5; 5.6] points. CVD risk was calculated with mSCORE, Reynolds Risk Score (RRS), ASSIGN, QRISK3, ERS-RA scales and Carotid Artery Doppler Ultrasound Exam was performed for all patients. Results. High risk was found in 5, 5, 14, 6, and 38% of patients according to mSCORE, RRS, ASSIGN, QRISK3, ERS-RA scales, respectively. Atherosclerotic plaques of carotid arteries were found in 30% of patients. It was found that carotid intima-media thickness is correlated to all CVR calculators, age, systolic and diastolic blood pressure, cholesterol, erythrocyte sedimentation rate, interleukin-6 levels. The sensitivity and specificity of the CVR algorithms in prognostication of atherosclerotic carotid artery lesions were 73 and 67% for mSCORE, 64 and 63% for RRS, 64 and 56% for ASSIGN, 73 and 49% for QRISK3, respectively, p0.05 in all cases, 67 and 50% for ERS-RA, p=0.06. Conclusion. RRS, mSCORE, ASSIGN, QRISK3 calculators equally predict atherosclerotic carotid artery damage in RA patients. The optimal ratio of specificity and sensitivity is shown for the mSCORE scale. Stratification of CVR in RA patients should include assessment of the carotid intima-media thickness. To identify CVR in RA patients, the most informative methods are mSCORE calculation and carotid intima-media thickness determination.

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“…Данные различных исследований указывают на экспрессию ИЛ-6 и его рецепторов в зонах сосудистого русла, наиболее подверженных атеросклеротическому поражению (коронарные артерии, сосуды головного мозга, периферические артерии) [60], а также на активацию иммунных клеток, участвующих в образовании и разрыве бляшек, в повреждении кардиомиоцитов [61][62][63] и в развитии эндотелиального повреждения, лежащего в основе атеросклероза [64,65].…”

Section: Discussionunclassified

Dynamics of traditional modifiable risk factors, total cardiovascular risk, and structural changes of carotid arteries in patients with rheumatoid arthritis on long-term interleukin-6 receptor antagonist treatment

Gerasimova¹,

Попкова²,

Martynova³

et al. 2021

Naučno-praktičeskaâ revmatologiâ

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The effect of an inhibitor of interleukin-6 (IL-6) receptors on the state of the cardiovascular system in patients with rheumatoid arthritis remains poorly understood.Objective: to study the effect of therapy with an inhibitor of IL-6 receptors, tocilizumab (TCZ), on the dynamics of modifiable risk factors, total cardiovascular risk, and structural changes in the carotid arteries in patients with rheumatoid arthritis during a 12-month follow-up period.Material and methods. The study included 40 patients with active rheumatoid arthritis (33 women and 7 men) with ineffectiveness and/or intolerance to basic anti-inflammatory drugs (DMARDs); the median age was 55 (49; 64) years, the duration of the disease – 102 (48; 162) months; DAS28 – 6.2 (5.5; 6.7) points; all patients were seropositive for rheumatoid factor, 80% – for antibodies to cyclic citrullinated peptide. Patients received TCZ 8 mg/kg therapy every 4 weeks: 52% received TCZ monotherapy, 48% received combined TCZ therapy with DMARDs. All patients underwent an assessment of traditional risk factors, the total cardiovascular risk was calculated using the mSCORE, and atherosclerotic vascular damage was assessed by the detection of atherosclerotic plaques.Results. After 12 months of TCZ therapy, a decrease in disease activity was noted: remission was observed in 25 patients (64%) with rheumatoid arthritis, low disease activity – in 12 (31%); DAS28, HAQ, CRP and ESR concentrations decreased significantly. А high frequency of traditional risk factors was found in rheumatoid arthritis patients: dyslipidemia – 67%, arterial hypertension – 65%, overweight – 55%, burdened heredity for cardiovascular diseases (CVD) – 35%, smoking – 15%. Every third patient had a combination of three or more traditional risk factors. After 12 months of TCZ therapy, the frequency of traditional risk factors did not significantly change, there was an increase in BMI by 2%, an increase in the concentration of HDL-C in serum by 27%, a decrease in the atherogenic index by 28% (p<0.01). Moreover, an increase in the level of HDL-C by the finish was found in patients regardless of statin therapy. Changes in the concentration of other lipids during the observation, including during therapy with statins, were not observed. A negative correlation the dynamics of the levels of ∆HS and ∆CRP (R=−0.37; p<0.05), ∆HS of LDL and ∆CRP (R=−0.42; p<0.01) was found. A very high cardiovascular risk according to the SCORE scale was determined in 78% of patients, moderate – in 2%, and low – in 20% of patients. The distribution of patients by mSCORE value and level of cardiovascular risk were not documented after 12 months of TCZ therapy. No significant structural changes in carotid arteries in rheumatoid arthritis patients were revealed by the end of 12 months of TCZ therapy.Conclusion. After 12 months of TCZ therapy resulted in decreased rheumatoid arthritis activity, increased the level of HDL-C, atherogenic index, BMI; the frequency of traditional risk factors and the total cardiovascular risk did not change. Despite the very high risk of developing CVD associated with the inflammatory activity of rheumatoid arthritis, the accumulation of traditional risk factors and their combination, subclinical atherosclerotic vascular lesions, no significant structural changes in the carotid arteries were found in rheumatoid arthritis patients on TCZ therapy. Insufficient effectiveness of statin therapy was revealed.

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Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

Cited by 12 publications

References 58 publications

High serum level of interleukin‑6 is linked with dyslipidemia in oral lichen planus

High serum level of interleukin‑6 is linked with dyslipidemia in oral lichen planus

Application of cardiovascular risk scales to identify carotid atherosclerosis in patients with rheumatoid arthritis

Dynamics of traditional modifiable risk factors, total cardiovascular risk, and structural changes of carotid arteries in patients with rheumatoid arthritis on long-term interleukin-6 receptor antagonist treatment

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