Repeated dosing with cocaine produces strain-dependent effects on responding for conditioned reinforcement in Collaborative Cross mice

Bailey, Lauren S.; Bagley, Jared R.; Wherry, James D.; Chesler, Elissa J.; Karkhanis, Anushree N.; Jentsch, J. David; Tarantino, Lisa M.

doi:10.1007/s00213-022-06256-9

Cited by 2 publications

(4 citation statements)

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“…CC strains have been observed to express a great deal of variation in drug-related traits. 18,[33][34][35] Phenotyping this reference panel of RI lines has revealed phenotypic variation much more extreme than originally observed in the eight inbred founder strains. The microbial differences include numerous taxa such as Acetatifactor, Amerpfustis, Anaeroplasma, Butyrivibrio, Catabacter, Christensenella, Eisenbergiella, Enterococcus, Klebsiella, Lactobacillus, Parvibacter, Robinsoniella, Roseburia, Ruminococcus, Syntrophococcus and several unclassified microbes among the 82 most abundant genera.…”

Section: Discussionmentioning

confidence: 90%

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The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

Tran,

Monroy Hernandez,

Nguyen

et al. 2023

Genes Brain and Behavior

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The gut-brain axis is increasingly recognized as an important pathway involved in cocaine use disorder. Microbial products of the murine gut have been shown to affect striatal gene expression, and depletion of the microbiome by antibiotic treatment alters cocaine-induced behavioral sensitization in C57BL/6J male mice. Some reports suggest that cocaine-induced behavioral sensitization is correlated with drug selfadministration behavior in mice. Here, we profile the composition of the naïve micro-

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Section: Discussionmentioning

confidence: 90%

“…CC strains have been observed to express a great deal of variation in drug‐related traits 18,33–35 . Phenotyping this reference panel of RI lines has revealed phenotypic variation much more extreme than originally observed in the eight inbred founder strains.…”

Section: Discussionmentioning

confidence: 98%

The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

Tran,

Monroy Hernandez,

Nguyen

et al. 2023

Genes Brain and Behavior

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“…These findings are consistent with host genetics controlling both the differential behavior observed in these two strains, their innate microbiome composition, and the microbiome's response to repeated drug exposure. CC strains have been observed to express a great deal of variation in addiction and addiction-related traits [18,[32][33][34]. Phenotyping this reference panel of RI lines has revealed phenotypic variation much more extreme than originally observed in the eight inbred founder strains.…”

Section: Discussion±mentioning

confidence: 98%

“…CC strains have been observed to express a great deal of variation in addiction and addiction-related traits[18, 32-34]. Phenotyping this reference panel of RI lines has revealed phenotypic variation much more extreme than originally observed in the eight inbred founder strains.…”

Section: Discussion±mentioning

confidence: 99%

The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

Tran

Hernandez

Nguyen

et al. 2022

Preprint

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The gut microbiome-brain axis is increasingly recognized as an important pathway in regulation of cocaine addiction. Microbial products produced in the murine gut have been shown to affect striatal gene expression, and depletion of the microbiome by antibiotic treatment alters cocaine-induced behavioral sensitization in C57BL/6J male mice. Cocaine-induced behavioral sensitization is correlated with drug self-administration behavior, therefore, is a predictor of addiction vulnerability. Here we profile the composition of the naïve microbiome and its response to cocaine sensitization in two Collaborative Cross (CC) strains. These strains display extremely divergent behavioral responses to cocaine sensitization. A high-responding strain, CC004/TauUncJ (CC04), has a gut microbiome that contains a greater amount ofLactobacillusthan the cocaine-nonresponsive strain CC041/TauUncJ (CC41). The gut microbiome of CC41 is characterized by an abundance ofEisenbergella, RobinsonellaandRuminococcus. In response to cocaine, CC04 has an increasedBarnsiellapopulation, while the gut microbiome of CC41 displays no significant changes. PICRUSt functional analysis of the functional potential of the gut microbiome in CC04 shows a significant number of Gut-Brain Modules altered after exposure to cocaine, specifically those encoding for tryptophan synthesis, glutamine metabolism, and menaquinone synthesis (vitamin K2). Depletion of the microbiome by antibiotic treatment revealed a sex-specific altered cocaine-sensitization response to antibiotics in female mice from CC04 that was not observed in male CC04 or either sex of CC41. Together these data suggest a complex relationship between host genetics, microbiome composition and cocaine sensitization behavior.FUNDINGU01DA043809 to JAB, GMW P50DA039841 to EJC

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Repeated dosing with cocaine produces strain-dependent effects on responding for conditioned reinforcement in Collaborative Cross mice

Cited by 2 publications

References 70 publications

The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

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