Abstract:The gut microbiome-brain axis is increasingly recognized as an important pathway in regulation of cocaine addiction. Microbial products produced in the murine gut have been shown to affect striatal gene expression, and depletion of the microbiome by antibiotic treatment alters cocaine-induced behavioral sensitization in C57BL/6J male mice. Cocaine-induced behavioral sensitization is correlated with drug self-administration behavior, therefore, is a predictor of addiction vulnerability. Here we profile the comp… Show more
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