Repeated application of incremental landing impact loads to intact knee joints induces anterior cruciate ligament failure and tibiofemoral cartilage deformation and damage: A preliminary cadaveric investigation

Yeow, Chen-Hua; Ng, Kian Siang; Cheong, C.H.; Lee, Peter Vee Sin; Goh, James Cho Hong

doi:10.1016/j.jbiomech.2009.03.026

Cited by 13 publications

(10 citation statements)

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“…Current work builds upon previous cadaveric studies (Wall et al, 2012, DeMorat et al, 2004, Hashemi et al, 2010, Meyer and Haut, 2008, Oh et al, 2012, Yeow et al, 2009) by generating ACL loading via axial compression and muscle loading in an unconstrained manner. This setup was designed to replicate the range of loading observed in vivo .…”

Section: Discussionmentioning

confidence: 99%

“…Over the past three decades, extensive efforts have been undertaken to study ACL biomechanics utilizing ex vivo approaches (Bach and Hull, 1998, Berns et al, 1992, Butler et al, 1980, DeMorat et al, 2004, Durselen et al, 1995, Gabriel et al, 2004, Hashemi et al, 2010, Markolf et al, 2004, Wu, 2010, Csintalan et al, 2006, Draganich and Vahey, 1990, Fukubayashi et al, 1982, Mazzocca et al, 2003, Meyer and Haut, 2008, Oh et al, 2012, Renstrom et al, 1986, Romero et al, 2002, Wall et al, 2012, Yeow et al, 2009, Zantop et al, 2007, Kiapour et al, 2012a). The majority of these studies simulate low-rate, sub-injurious tasks through the application of static and/or quasi-static loading conditions(Bach and Hull, 1998, Berns et al, 1992, Butler et al, 1980, Csintalan et al, 2006, Draganich and Vahey, 1990, Durselen et al, 1995, Fukubayashi et al, 1982, Gabriel et al, 2004, Markolf et al, 2004, Mazzocca et al, 2003, Renstrom et al, 1986, Romero et al, 2002, Wu, 2010, Zantop et al, 2007, Kiapour et al, 2012a).…”

Section: Introductionmentioning

confidence: 99%

“…Experimental strategies have been developed to replicate high-risk, potentially injurious conditions and reproduce ACL injury (Wall et al, 2012, DeMorat et al, 2004, Hashemi et al, 2010, Meyer and Haut, 2008, Oh et al, 2012, Withrow et al, 2006, Yeow et al, 2009). Such experiments have focused on a variety of causative factors including muscle loading (DeMorat et al, 2004, Hashemi et al, 2010, Wall et al, 2012, Withrow et al, 2008), axial compression (Yeow et al, 2009, Wall et al, 2012, Meyer and Haut, 2008), and off-axis external loads (Withrow et al, 2006, Oh et al, 2012, Meyer and Haut, 2008) to simulate landing.…”

Section: Introductionmentioning

confidence: 99%

“…Such experiments have focused on a variety of causative factors including muscle loading (DeMorat et al, 2004, Hashemi et al, 2010, Wall et al, 2012, Withrow et al, 2008), axial compression (Yeow et al, 2009, Wall et al, 2012, Meyer and Haut, 2008), and off-axis external loads (Withrow et al, 2006, Oh et al, 2012, Meyer and Haut, 2008) to simulate landing. Yet, such models are primarily limited by non-physiologic simulation of dynamic loading conditions (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Timing sequence of multi-planar knee kinematics revealed by physiologic cadaveric simulation of landing: Implications for ACL injury mechanism

Kiapour

Quatman

Goel

et al. 2014

Clinical Biomechanics

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Background Challenges in accurate, in vivo quantification of multi-planar knee kinematics and relevant timing sequence during high-risk injurious tasks pose challenges in understanding the relative contributions of joint loads in non-contact injury mechanisms. Biomechanical testing on human cadaveric tissue, if properly designed, offers a practical means to evaluate joint biomechanics and injury mechanisms. This study seeks to investigate detailed interactions between tibiofemoral joint multi-planar kinematics and anterior cruciate ligament strain in a cadaveric model of landing using a validated physiologic drop-stand apparatus. Methods Sixteen instrumented cadaveric legs, 45(SD 7) years (8 female and 8 male) were tested. Event timing sequence, change in tibiofemoral kinematics (position, angular velocity and linear acceleration) and change in anterior cruciate ligament strain were quantified. Findings The proposed cadaveric model demonstrated similar tibiofemoral kinematics/kinetics as reported measurements obtained from in vivo studies. While knee flexion, anterior tibial translation, knee abduction and increased anterior cruciate ligament strain initiated and reached maximum values almost simultaneously, internal tibial rotation initiated and peaked (p<0.015 for all comparisons) significantly later. Further, internal tibial rotation reached 1.8(SD 2.5)°, almost 63% of its maximum value, at the time that peak anterior cruciate ligament strain occurred, while both anterior tibial translation and knee abduction had already reached their peaks. Interpretation Together, these findings indicate that although internal tibial rotation contributes to increased anterior cruciate ligament strain, it is secondary to knee abduction and anterior tibial translation in its effect on anterior cruciate ligament strain and potential risk of injury.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Timing sequence of multi-planar knee kinematics revealed by physiologic cadaveric simulation of landing: Implications for ACL injury mechanism

Kiapour

Quatman

Goel

et al. 2014

Clinical Biomechanics

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“…ACLT models have been shown to induce osteoarthritic type changes that appear to differ when compared to OA-type changes induced by traumatic loading (Killian et al, 2010). A traumatic loading model may more directly recapitulate the common jump landing injury (Levine et al, 2013; Meyer and Haut, 2005; Yeow et al, 2009), and joint injury has been shown to increase the risk of OA development (Blagojevic et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

An optimized transversely isotropic, hyper-poro-viscoelastic finite element model of the meniscus to evaluate mechanical degradation following traumatic loading

Wheatley¹,

Fischenich²,

Button³

et al. 2015

Journal of Biomechanics

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Inverse finite element (FE) analysis is an effective method to predict material behavior, evaluate mechanical properties, and study differences in biological tissue function. The meniscus plays a key role in load distribution within the knee joint and meniscal degradation is commonly associated with the onset of osteoarthritis. In the current study, a novel transversely isotropic hyper-poro-viscoelastic constitutive formulation was incorporated in a FE model to evaluate changes in meniscal material properties following tibiofemoral joint impact. A non-linear optimization scheme was used to fit the model output to indentation relaxation experimental data. This study is the first to investigate rate of relaxation in healthy versus impacted menisci. Stiffness was found to be decreased (p=0.003), while the rate of tissue relaxation increased (p=0.010) at twelve weeks post impact. Total amount of relaxation, however, did not change in the impacted tissue (p=0.513).

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Joint loads resulting in ACL rupture: Effects of age, sex, and body mass on injury load and mode of failure in a mouse model

2016

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Anterior cruciate ligament (ACL) tears are a common knee injury with a known but poorly understood association with secondary joint injuries and post-traumatic osteoarthritis (OA). Female sex and age are known risk factors for ACL injury but these variables are rarely explored in mouse models of injury. This study aimed to further characterize a non-surgical ACL injury model to determine its clinical relevance across a wider range of mouse specifications. Cadaveric and anesthetized C57BL/6 mice (9-52 weeks of age) underwent joint loading to investigate the effects of age, sex, and body mass on ACL injury mechanisms. The ACL injury load (whole joint load required to rupture the ACL) was measured from force-displacement data, and mode of failure was assessed using micro-dissection and histology. ACL injury load was found to increase with body mass and age (p < 0.001) but age was not significant when controlling for mass. Sex had no effect. In contrast, the mode of ACL failure varied with both age and sex groups. Avulsion fractures (complete or mixed with mid-substance tears) were common in all age groups but the proportion of mixed and mid-substance failures increased with age. Females were more likely than males to have a major avulsion relative to a mid-substance tear (p < 0.01). This data compliments studies in human cadaveric knees, and provides a basis for determining the severity of joint injury relative to a major ACL tear in mice, and for selecting joint loading conditions in future experiments using this model. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1754-1763, 2017.

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Repeated application of incremental landing impact loads to intact knee joints induces anterior cruciate ligament failure and tibiofemoral cartilage deformation and damage: A preliminary cadaveric investigation

Cited by 13 publications

References 43 publications

Timing sequence of multi-planar knee kinematics revealed by physiologic cadaveric simulation of landing: Implications for ACL injury mechanism

Timing sequence of multi-planar knee kinematics revealed by physiologic cadaveric simulation of landing: Implications for ACL injury mechanism

An optimized transversely isotropic, hyper-poro-viscoelastic finite element model of the meniscus to evaluate mechanical degradation following traumatic loading

Joint loads resulting in ACL rupture: Effects of age, sex, and body mass on injury load and mode of failure in a mouse model

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