Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus

Li, Ye; Gokul, Akilesh; McGhee, Charles N J; Ziaei, Mohammed

doi:10.1371/journal.pone.0248350

Cited by 7 publications

(9 citation statements)

References 35 publications

(61 reference statements)

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“…Repeatability of the thinnest corneal thickness and central corneal thickness was the lowest compared with other parameters with the Pentacam-AXL. We found that the repeatability of the Revo-NX–derived central corneal thickness and thinnest corneal thickness measurements were comparable with previous studies of keratoconic eyes, although our study showed higher precision 7,16 …”

Section: Discussionsupporting

confidence: 88%

“…We found that the repeatability of the Revo-NX-derived central corneal thickness and thinnest corneal thickness measurements were comparable with previous studies of keratoconic eyes, although our study showed higher precision. 7,16 However, in our study, the Revo-NX was more precise than the Pentacam-AXL in thinnest corneal thickness parameters. In contrast, in other studies, the Pentacam-AXL was superior in both central corneal thickness and thinnest corneal thickness measurements.…”

Section: Discussioncontrasting

confidence: 69%

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Comparing Repeatability and Agreement between Commonly Used Corneal Imaging Devices in Keratoconus

Angelo,

Gokul,

McGhee

et al. 2023

Optom Vis Sci

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Significance Keratometry and pachymetry are important for diagnosis and monitoring of keratoconus. Many corneal imaging units exist but comparison to determine repeatability and agreement are paramount for adequate keratoconus management in primary and secondary care. Purpose To evaluate the repeatability and agreement of a Placido disc-based videokeratoscope (Medmont-E300 topographer) used in primary care with spectral-domain optical coherence tomography (Revo-NX) and Scheimpflug corneal tomography (Pentacam-AXL) in secondary-care. Methods This was a prospective, single-center study where one eye was randomized to have central and thinnest corneal thickness (CCT, TCT) and maximum, mean, steep and flat keratometry (Kmax, Kmean, Ksteep and Kflat), measured with all three devices. Three measurements were completed per device to assess intra-observer repeatability. Results 110 eyes from 110 patients with keratoconus were analyzed. Repeatability was best with the Pentacam for CCT, Kmax, Kmean, Ksteep and Kflat parameters (precision = 9.21,0.8,0.38,0.52,0.58). The Medmont had better repeatability than the Revo with Kmax, Kmean, Ksteep and Kflat (precision = 1.41,1.35,1.43,1.59). Revo had the best repeatability with TCT (precision = 3.81). The intraclass correlation coefficient was ˃0.94 for all parameters in all devices. Agreement was generally poor between devices. However, there was good agreement between Pentacam and Medmont Kflat measurements (P˃.05). Conclusions Repeatability of keratometry parameters with the Pentacam and Medmont were greater than the Revo, suggesting a lower threshold for change for anterior corneal changes. The Revo had the greatest repeatability for TCT, suggesting a lower threshold for assessing thinning in disease progression and corneal-crosslinking safety. There was poor agreement between devices so devices cannot be used interchangeably.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 69%

Comparing Repeatability and Agreement between Commonly Used Corneal Imaging Devices in Keratoconus

Angelo,

Gokul,

McGhee

et al. 2023

Optom Vis Sci

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“…However, the CoV was slightly higher than the one reported for the RTVue device, for which a CoV in the central zone of 1.07% has been reported in unoperated eyes [ 4 ]. The repeatability of the REVO NX ETMs found in this study cannot be directly compared to the values reported in the literature by other authors using REVO NX because they made maps based on a 5-mm averaged radial scan without an anterior adapter [ 17 ]. Like in other studies, the superior quadrants were found to be the thinnest while the inferior was the thickest [ 18 ].…”

Section: Discussionmentioning

confidence: 66%

Simultaneous Corneal Topography and Epithelial Thickness Mapping from a Single Measurement Using Optical Coherence Tomography

Sikorski

2022

Journal of Ophthalmology

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Purpose. To evaluate the performance of corneal epithelial thickness mapping (ETM) and demonstrate simultaneous measurement of ETMs and corneal topography using REVO NX (Optopol Technology, Zawiercie, Poland)—an OCT device for anterior and posterior segment imaging. Methods. One hundred thirty-seven eyes of 137 normal subjects and patients with corneal diseases were recruited to the study. Each subject was scanned with REVO NX. ETMs and corneal topography maps were reconstructed from a single measurement. Corneal topography was also carried out using Pentacam (Oculus, Wetzlar, Germany). One hundred twenty-eight eyes were qualified for the final analysis. Forty healthy eyes were used to evaluate the performance of ETM, and 88 eyes were used to compare ETMs and corneal topography. The repeatability and reproducibility of ETMs in healthy subjects were assessed on the basis of 17 spatial zones derived from an 8-mm diameter corneal scan using within-subject standard deviation, test-retest repeatability, within-subject coefficient of variation (CoV), and intraclass correlation coefficient (ICC). Results. The ICC for both repeatability and reproducibility of ETMs for the central sector was 0.95. The ICC value for the other sectors was only moderately lower. However, the CoV for repeatability (≤1.55%) was slightly higher than the value reported for the RTVue device (Optovue, Inc, Fremont, California, USA), for which a CoV in the central zone of 1.07% was reported in unoperated eyes. The superior quadrants were found to be the thinnest while the inferior ones were the thickest. ETMs and topography maps created from a single OCT measurement present a complementary image of the cornea. Conclusions. ETMs obtained using REVO NX show high levels of repeatability and reproducibility in normal eyes. Because the topographic and epithelial thickness analyses are performed using the same data, which means they are based on the exact same 3D corneal model, they do not require reciprocal centration and map matching. This ensures a complete point-to-point correlation between ETMs and corneal topography maps, which paints a fuller picture of a given pathology.

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“…The corneal epithelium is a strati ed, nonkeratinized layer with a thickness of 48-53µm in healthy eyes, which has previously been shown to be moldable. It has an asymmetrical thickness pro le, being slightly thicker inferiorly and nasally [32,33].…”

Section: Discussionmentioning

confidence: 99%

Relationship of Central Corneal Thickness and Central Corneal Epithelial Thickness with Anthropoemetric and Biochemical Data in Individuals with Impaired Glucose Metabolism

Boyacı

Demirci

2023

Preprint

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Background Measure central corneal thickness (CCT) and central corneal epithelial thickness (CCET) with anterior segment-optical coherence tomography (AS-OCT) in individuals with impaired glucose metabolism and to analyze, the effect of impaired glucose metabolism on the cornea.Methods 140 eyes of 70 participants, including 20 healthy controls, 17 insulin resistant, and 33 prediabetic, were evaluated by AS-OCT. Glucose metabolism was examined using a 2-hour 75 g oral glucose tolerance test and glycated haemoglobin A1c (HbA1c). Anthropoemetric measurements, physical examinations, and blood pressure were recorded of all participants. The biochemical parameters were studied.Results The mean age of the participants was 37.93 ± 12.30 years, and the mean HbA1c was 5.50 ± 0.38%. CCET measurements were significantly different and higher in the prediabetic group (p < 0.01). A significant positive correlation was found between both CCETR and CCETL and age, HbA1c, and fasting plasma glucose (p < 0.05). There was found a significant positive correlation was found between CCETR and total cholesterol, triglyceride, and low-density lipoprotein (p < 0.05). Anthropoemetric parameters were significantly different in prediabetics (p˂0.001 and p˂0.05). There was a significant negative correlation between body fat percentage and CCT (p˂0.05). CCET showed a significant positive correlation with neck circumference (p < 0.05).Conclusions It may be suggested that impaired metabolic processes during prediabetes may affect CCET. We believe that prediabetes detection should not be limited to HbA1c and OGTT; A multifactorial algorithm could be developed. AS-OCT may be an easily accessible and useful tool for the early diagnosis of prediabetes.

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Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus

Cited by 7 publications

References 35 publications

Comparing Repeatability and Agreement between Commonly Used Corneal Imaging Devices in Keratoconus

Comparing Repeatability and Agreement between Commonly Used Corneal Imaging Devices in Keratoconus

Simultaneous Corneal Topography and Epithelial Thickness Mapping from a Single Measurement Using Optical Coherence Tomography

Relationship of Central Corneal Thickness and Central Corneal Epithelial Thickness with Anthropoemetric and Biochemical Data in Individuals with Impaired Glucose Metabolism

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