Repeatability in column preparation of a reversed-phase C18 monolith and its application to separation of tocopherol homologues

Polymer monolith microextraction using poly(butyl methacrylate-co-1,6-hexanediol ethoxylate diacrylate) monolithic sorbent for determination of phenylurea herbicides in water samples

“…2. As described in the previous study [26], the two ether-linkages in the alkyl bridge of HEDA offered additional hydrophilic interactions between analytes and monolithic materials compared to other polymeric monolith-based stationary phases used in reversed-phase LC [27][28][29][30]. The additional hydrophilic interactions allow retention of relatively polar analytes, such as PUHs, in water samples onto the HEDA-based monolithic sorbent for extraction.…”

Preparation and evaluation of poly(alkyl methacrylate-co-methacrylic acid-co-ethylene dimethacrylate) monolithic columns for separating polar small molecules by capillary liquid chromatography

“…Since the introduction of polymer-based monoliths in early 1990s [1,2], the polymer-based monoliths have served as stationary phases in different types of chromatographic separation modes such as reversed-phase capillary liquid chromatography (LC) [3][4][5][6][7][8], ion-exchange chromatography [9][10][11][12], and capillary electrochromatography (CEC) [13][14][15]. A number of review articles have been published to discuss the chemistry of monolith polymerization [16,17] as well as the development and applications [18][19][20][21] of polymer-based monoliths.…”

Repeatability of Octadecyl Methacrylate-Based Monolithic Columns for Capillary Electrochromatography

“…Monoliths can be inorganic, often based on silica, [4][5][6] or organic, based on methacrylates, styrenes or acrylamides. [7][8][9][10][11] Methacrylatebased monoliths can be prepared having different surface hydrophobicities, depending on the monomer used. The most used methacrylate monomers for synthesis of monolithic stationary phases for use in CEC use C4 (butyl methacrylate), [12,13] C12 (lauryl methacrylate) [7] and C18 (octadecyl methacrylate) [8] substituents.…”

“…[7][8][9][10][11] Methacrylatebased monoliths can be prepared having different surface hydrophobicities, depending on the monomer used. The most used methacrylate monomers for synthesis of monolithic stationary phases for use in CEC use C4 (butyl methacrylate), [12,13] C12 (lauryl methacrylate) [7] and C18 (octadecyl methacrylate) [8] substituents. Organic monoliths are chemically stable over a wide range of pH (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12), a stability that is not possible with the types of silica presently on the market, which dissolves in highly basic media.…”

“…The most used methacrylate monomers for synthesis of monolithic stationary phases for use in CEC use C4 (butyl methacrylate), [12,13] C12 (lauryl methacrylate) [7] and C18 (octadecyl methacrylate) [8] substituents. Organic monoliths are chemically stable over a wide range of pH (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12), a stability that is not possible with the types of silica presently on the market, which dissolves in highly basic media. Careful control of the polymerization process (through variation in the type and proportion of porogenic solvents or variation in the proportion of these with respect to monomers) enables optimization of the porous properties and, consequently, of the efficiency and selectivity of the separation.…”