Abstract:In selected patients, repeat hepatectomy for recurrent gastric cancer liver metastasis may offer the same chance of cure as the primary hepatectomy. Disease-free intervals exceeding 12 months predict good patient survival after repeat hepatectomy.
“…Repeat hepatectomy was performed in only 14·4 per cent of patients. Compared with liver metastases from colorectal cancer, there is less opportunity for repeat hepatectomy for GCLMs because the recurrence pattern is more complex; however, repeat hepatectomy can be considered if the hepatic recurrence is solitary.…”
“…Repeat hepatectomy was performed in only 14·4 per cent of patients. Compared with liver metastases from colorectal cancer, there is less opportunity for repeat hepatectomy for GCLMs because the recurrence pattern is more complex; however, repeat hepatectomy can be considered if the hepatic recurrence is solitary.…”
“…Takemura et al [26] reported a 5-year survival rate and MST of 47 % and 31 months, respectively, in 14 patients who underwent repeat hepatectomy for recurrence in the liver remnant. Two of the three patients who underwent repeat hepatectomy in our study also achieved long-term survival, suggesting that resection may be considered if the aforementioned indications are met.…”
Background Chemotherapy is the standard treatment for liver metastases of gastric cancer (LMGC). Hepatectomy for LMGC reportedly has a 5-year survival rate of 13-37 %; however, its significance has not been established. At our hospital, hepatectomy is performed for patients with three or fewer metastases diagnosed using contrast-enhanced magnetic resonance imaging (MRI). To identify the ideal patient subpopulation for resection, we retrospectively analyzed treatment outcomes in patients with LMGC who underwent hepatectomy. Methods Clinicopathological factors affecting survival were explored using univariate and multivariate analyses in 28 patients who underwent hepatectomy for LMGC diagnosed using contrast-enhanced MRI between December 2004 and October 2014. Results The study included 23 men and 5 women with a median age of 72 years. Metastases were synchronous in 15 patients and metachronous in 13 patients. The median overall survival time was 49 months, with a 5-year survival rate of 32 %. Univariate analysis revealed that overall survival time was shorter in the presence of the following factors: age C70 years (p = 0.030), synchronous liver metastases (p = 0.017), and presence of postoperative complications (p = 0.042). In patients with metachronous liver metastases, the post-resection 5-year survival rate was 59 %. Conclusions The 5-year survival rate was 32 % in patients who underwent hepatectomy for LMGC according to our criteria, suggesting that hepatectomy is an important treatment if indications are on the basis of contrast-enhanced MRI. Therefore, active resection should be considered, particularly for patients with metachronous liver metastases.
“…In particular, overall 5-year survival rate of gastric cancer metastatic to the liver ranges between 0 and 10% [58,59,92], whereas it rises up to 20% after curative hepatectomy in the literature [64-68, 73, 93]. Furthermore, taking into consideration the only article about hepatic metastasis local re-treatment after recurrence, the authors found a survival advantage in local treatment repetition [94].…”
Section: Liver Metastases From Gastric Cancermentioning
Taking into consideration all primary solid tumors, the liver represents the most common site involved in distant metastasization, also due to its important blood reception from the majority of digestive organs. Despite the abundant literature and guidelines about colorectal liver metastases, there is still great debate about the treatment strategy in the case of non-colorectal ones. Therefore, in this chapter, we reviewed the treatment strategy and surgical indications for the most frequent non-colorectal liver metastases. In the case of neuroendocrine hepatic secondaries, the literature suggests that surgery should be always considered for patients with resectable hepatic disease, as this treatment results more likely to offer the best long-term outcome. For what concerns liver metastases from gastric cancer, surgical approach should always be undertaken if indications are appropriate, after a multidisciplinary discussion to plan an adequate multidisciplinary adjuvant treatment, a proper patient selection, and the exclusion of additional secondary tumors or extrahepatic metastases. Taking into consideration liver secondaries from breast cancer and their chemosensitivity, in the absence of brain and lung lesions, it can be considered a space for liver surgery, especially in the case of single lesions or a maximum of two lesions with dimensions within 3 cm. However, as the number of cancer survivors is progressively increasing and, with it, the number of patients affected by non-colorectal liver metastases, further randomized controlled trials are required in order to better define the benefit of hepatic surgery in these kinds of patients.
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