Repairing Holes in the Head: A History of Cranioplasty

Sanan, Abhay; Haines, Stephen J.

doi:10.1227/00006123-199703000-00033

Cited by 77 publications

(68 citation statements)

References 46 publications

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“…However, the limited donor supply and potential risks of infection from HBV and HIV are still the main reasons for limiting the use of allogeneic bones in bone grafting. Although the earliest records of bone graft were those of bone xenografts (Galvan et al 2006;Sanan and Haines 1997), the xenografts could not be used clinically due to the risk for extensive immunological rejection. Professor Hu Yunyu, the creator of the multi-variety bone bank, developed a biological composite termed the reconstituted bone xenograft (RBX) by chemically treating fresh calf cancellous bones to make them antigen-free and combining them with an extract of calf cortical bones that is from derived bovine bone morphogenetic protein (bBMP), a strong osteoinductive growth factor.…”

Section: The Application Of Xenograftsmentioning

confidence: 99%

Multi-variety bone bank in China

Meng

et al. 2009

Cell Tissue Bank

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This is a descriptive report of the establishment and operation of a Chinese bone bank, though not a typical one. While being engaged in collection, processing and storage of allogeneic tissues, the bone bank to which the author belongs concurrently develops and produces new, non-human derived, graft materials. Among others is reconstituted bone xenograft (RBX) which possesses strong osteoinductive capability without evoking immune rejection. Hence, its appellation "multi-variety bone bank," which was established by Dr. Hu Yunyu in 1990, the first of its kind in China. There are several salient features discriminating this bone bank from others. At this hospital-based non-profit institution, allograft hemi-joints are freshly prepared and distributed deep-frozen, instead of being freeze-dried on an industrialized basis for convenient transportation. The former has much more superior biological and mechanical properties as compared with the latter. However, allogeneic tissues are sometimes in short supply due to limited number of donors and the risk of some potential donors carrying viruses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV). New graft materials, including reconstituted bone xenograft (RBX), were developed that serve as a supplement to allografts. RBX has been successfully used in clinical practice for the management of old fractures, nonunions and bone defects, most notably of contaminated, infected open fractures and osteomyelitis with the use of anti-infective reconstituted bone xenograft (ARBX). Additionally the multi-variety bone bank serves as a training base for educating professional personnel and researchers (postgraduates) in theories and technologies of tissue banking. Up to now, eighteen special technical staff members and approximately sixty senior researchers have been trained at this institution.

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Section: The Application Of Xenograftsmentioning

confidence: 99%

Multi-variety bone bank in China

Meng

et al. 2009

Cell Tissue Bank

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“…Für den Verschluss von knöchernen Schädeldefekten sind vielfältige Materialien und Methoden beschrieben worden [19]. Die Anforderungen an den idealen Knochenersatz sind jedoch so umfassend (s. Tabelle [21,31].…”

Section: Diskussionunclassified

Rekonstruktion des Os frontale mit individuellen Titanimplantaten nach chirurgischer Therapie der Stirnbeinosteomyelitis

Bücheler

Weihe

Eufinger

et al. 2002

HNO

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Individually prefabricated titanium implants enable the reconstruction of the frontal bone after surgical therapy of osteomyelitis without compromising mechanical stability or aesthetic results. Primarily the infected bone tissue is removed. Helical computed tomographic systems are used for the aquisition of patient data. After being transmitted to a computer aided design system (CAD-system) this data is used for construction of the implant geometry using freeform-surfaces. The outer surface contour is derived from the contours of the bone defect. The completed computer-based implant design is finally transformed into control data to run the milling machine which produces the implant from a block of titanium. Modern industrial CAD/CAM-technology allows standardized prefabrication using data from CT-scans. The precision of all implants was predictable and duration of the reconstructive procedure could be reduced. During postoperative follow-up (5-24 months) no loss of implant or recurrence of the osteomyelitis could be observed.

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“…1,2 More recently, Kocher and Cushing popularized decompressive craniectomy; indications include stroke, intracranial hemorrhage, and trauma. 2e5 With the upswing of craniectomies came a modernization of a secondary necessary intervention: cranioplasty.…”

Section: Introductionmentioning

confidence: 99%