Repair of large full-thickness cartilage defect by activating endogenous peripheral blood stem cells and autologous periosteum flap transplantation combined with patellofemoral realignment

Fu, Weili; Ao, Yingfang; Ke, Xiaoyan; Zheng, Zhuozhao; Gong, Xiaofeng; Jiang, Dong; Yu, Jia-Kuo

doi:10.1016/j.knee.2013.10.010

Cited by 36 publications

(40 citation statements)

References 19 publications

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“…74–76 A randomized trial investigated articular cartilage regeneration in patients aged 18–50 years with knee chondral lesions (ICRS grade 3 and grade 4 lesions) treated with arthroscopic subchondral drilling followed by postoperative intra-articular injections of hyaluronic acid, with or without PBSCs. The study found the PBSC group had improved quality of cartilage as shown in the ICRS visual assessment scale histology score and an MRI-based morphological score over those of the control group 18 months after injection.…”

Section: Future Regenerative Approachesmentioning

confidence: 99%

Repair and tissue engineering techniques for articular cartilage

et al. 2014

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Chondral and osteochondral lesions due to injury or other pathology commonly result in the development of osteoarthritis, eventually leading to progressive total joint destruction. Although current progress suggests that biologic agents can delay the advancement of deterioration, such drugs are incapable of promoting tissue restoration. The limited ability of articular cartilage to regenerate renders joint arthroplasty an unavoidable surgical intervention. This Review describes current, widely used clinical repair techniques for resurfacing articular cartilage defects; short-term and long-term clinical outcomes of these techniques are discussed. Also reviewed is a developmental pipeline of regenerative biological products that over the next decade could revolutionize joint care by functionally healing articular cartilage. These products include cell-based and cell-free materials such as autologous and allogeneic cell-based approaches and multipotent and pluripotent stem-cell-based techniques. Central to these efforts is the prominent role that tissue engineering has in translating biological technology into clinical products; therefore, concomitant regulatory processes are also discussed.

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Section: Future Regenerative Approachesmentioning

confidence: 99%

Repair and tissue engineering techniques for articular cartilage

et al. 2014

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“…32,33 PBSCs are able to differentiate into the mesenchymal lineage including cartilage, bone, and adipose tissue in vitro, 34,35 with clinical studies showing PBSCs' potential for cartilage repair. 14,15,20,21 The chondrocyte differentiation potential of stem cells derived from both peripheral blood and bone marrow has been shown to be similar in both in vitro and in vivo studies. 36,37 HSCs, MSCs, and growth factors in PBSCs play an important role in differentiating cells to initiate chondrogenesis, as well as providing paracrine effects to maturing repair tissue.…”

Section: High Tibial Osteotomy and Chondrogenesismentioning

confidence: 99%

“…[11][12][13][14][15][16][17][18][19] Studies have shown success with combining arthroscopic marrow stimulation and postoperative intra-articular injections of stem cells in combination with hyaluronic acid (HA). 14,[19][20][21][22][23][24][25] We have previously published our clinical results involving a case series and a randomized controlled trial after arthroscopic subchondral drilling in combination with postoperative intra-articular injections of peripheral blood stem cells (PBSCs) and HA.…”

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confidence: 99%

High Tibial Osteotomy in Combination With Chondrogenesis After Stem Cell Therapy: A Histologic Report of 8 Cases

Saw

Anz

Jee

et al. 2015

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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“…There were two studies that examined cartilage regeneration following the realignment procedures combined with cell therapy. Fu et al reported the case of a 19-year-old patient who underwent patellofemoral realignment procedure combined with two-stage peripheral blood-derived cells and periosteal flap transplantations [70]. Second-look arthroscopy showed a smooth surface at the repair site, and the patient resumed sports activities at 7.5 years after surgery.…”

Section: Peripheral Blood-derived Progenitor Cellsmentioning

confidence: 99%

Cartilage repair techniques in the knee: stem cell therapies

Yoshiya

Dhawan

2015

Curr Rev Musculoskelet Med

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Among the surgical options for large full-thickness chondral injuries, cell-based therapy has been practiced and its satisfactory outcomes have been reported. One area that appears promising is cell-based therapies utilizing stem cells. Various tissues within the human body contain mesenchymal stem cells (MSCs) from where these can be harvested. These include bone marrow, adipose, synovium, peripheral blood, and umbilical cord. In this article, both preclinical animal studies and clinical studies dealing with the use of MSCs for cartilage repair of the knee are reviewed. Majority of the clinical papers have shown promising results; however, there are a limited number of studies of high evidence level. Clinical significance of the stem cell therapy as compared to other surgical options as well as optimization of the procedure in terms of cell type and delivery method is still to be determined.

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Repair of large full-thickness cartilage defect by activating endogenous peripheral blood stem cells and autologous periosteum flap transplantation combined with patellofemoral realignment

Cited by 36 publications

References 19 publications

Repair and tissue engineering techniques for articular cartilage

Repair and tissue engineering techniques for articular cartilage

High Tibial Osteotomy in Combination With Chondrogenesis After Stem Cell Therapy: A Histologic Report of 8 Cases

Cartilage repair techniques in the knee: stem cell therapies

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