High Tibial Osteotomy in Combination With Chondrogenesis After Stem Cell Therapy: A Histologic Report of 8 Cases

Saw, Khay-Yong; Anz, Adam W.; Jee, Caroline Siew-Yoke; Ng, Reza Ching-Soong; Mohtarrudin, Norhafizah; Ragavanaidu, Kunaseegaran

doi:10.1016/j.arthro.2015.03.038

Cited by 52 publications

(55 citation statements)

References 58 publications

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“…The only clinical comparative study between stem cell types in cartilage regeneration is the study of Skowroński and Rutka [36] showing superior results for PBSC versus BM. The possibility of using autologous PBSCs obtained by leukapheresis after hG-CSF stimulation was first introduced by Saw et al [13,14,16] who treated chondral knee lesions with subchondral drilling and five postoperative IA injections of PBSCs and HA, reporting no adverse reactions and positive histological findings. In a pilot study, Turajane et al [18] demonstrated that a similar combination of IA AAPBSC with or without GFA along with HA in conjunction with arthroscopic MCS resulted in quality-of-life improvements measured by WOMAC and KOO scores and succeeded in regenerating articular cartilage in early osteoarthritic knee disease that failed conservative treatment versus noncellular interventions without adverse reactions.…”

Section: Discussionmentioning

confidence: 99%

“…Cellular therapy for human adult use usually means that autologous nucleated cells are harvested via either bone marrow (BM) aspiration or peripheral blood (PB) stem cell collection through leukapheresis or via liposuction [11]. Cellular therapies for treating various stages of human OA have recently provided successful and encouraging clinical and laboratory results using the combination of intra-articular (IA) autologous activated peripheral blood stem cells (AAPBSCs) [12][13][14][15][16] with or without growth factor addition (GFA) [17,18] along with hyaluronic acid (HA) in conjunction with arthroscopic microdrilling mesenchymal cell stimulation (MCS) in regenerating articular cartilage. In this randomized controlled trial, in early OA that failed conservative intervention, the clinical outcomes [primary endpoint: the need for total knee arthroplasty (TKA); secondary endpoint: WOMAC scores] following a combination of arthroscopic microdrilling mesenchymal cell stimulation (MCS) and repeated intraarticular (IA) autologous activated peripheral blood stem cells (AAPBSCs) with and without growth factor addition (GFA) along with hyaluronic acid (HA) versus IA-HA alone were evaluated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Avoidance of total knee arthroplasty in early osteoarthritis of the knee with intra-articular implantation of autologous activated peripheral blood stem cells versus hyaluronic acid: A randomized controlled trial with differential effects of growth factor addition

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Avoidance of total knee arthroplasty in early osteoarthritis of the knee with intra-articular implantation of autologous activated peripheral blood stem cells versus hyaluronic acid: A randomized controlled trial with differential effects of growth factor addition

et al. 2017

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“…Both of the studies demonstrated successful results in the treatment of regenerated cartilage. In the histological evaluation, proteoglycan and type II collagen proportion was substantially increased and achieved 95% of the normal articular cartilage score (31). …”

Section: Resultsmentioning

confidence: 99%

The Current Perspectives of Stem Cell Therapy in Orthopedic Surgery

Akpancar¹,

Tatar

Turğut

et al. 2016

Arch Trauma Res

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ContextMusculoskeletal injuries may be painful, troublesome, life limiting and also one of the global health problems. There has been considerable amount of interest during the past two decades to stem cells and tissue engineering techniques in orthopedic surgery, especially to manage special and compulsive injuries within the musculoskeletal system.Evidence AcquisitionThe aim of this study was to present a literature review regarding the most recent progress in stem cell procedures and current indications in orthopedics clinical care practice. The Medline and PubMed library databases were searched for the articles related with stem cell procedures in the field of orthopedic surgery and additionally the reference list of each article was also included to provide a comprehensive evaluation.ResultsVarious sources of stem cells have been studied for orthopedics clinical care practice. Stem cell therapy has successfully used for major orthopedic procedures in terms of bone-joint injuries (fractures-bone defects, nonunion, and spinal injuries), osteoarthritis-cartilage defects, ligament-tendon injuries, femoral head osteonecrosis and osteogenesis imperfecta. Stem cells have also used in bone tissue engineering in combining with the scaffolds and provided faster and better healing of tissues.ConclusionsLarge amounts of preclinical studies have been made of stem cells and there is an increasing interest to perform these studies within the human population but preclinical studies are insufficient; therefore, much more and efficient studies should be conducted to evaluate the efficacy and safety of stem cells.

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“…12 Correction of mechanical malalignment, such as varus, with high tibial osteotomy has shown to be instrumental in combination with stem cell augmentation. 49,50 Table 3 outlines all the studies discussed above, and a few additional studies that have used stem cell related products without tissue engineering with at least 10 patients in the investigation. 16 …”

Section: Cartilage Repair In Regenerative Medicinementioning

confidence: 98%

Concepts in regenerative medicine: Past, present, and future in articular cartilage treatment

Anz

Bapat²,

Murrell

2016

Journal of Clinical Orthopaedics and Trauma

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Regenerative medicine is emerging with great interest and hope from patients, industry, academia, and medical professionals. Cartilage regeneration, restoration, or repair is one of the prime targets that remains largely unsolved, and many believe that regenerative medicine can possibly deliver solutions that can be widely used to address the current gap(s) in treatment. In the United States, Europe, Australia, and India the regulation of regenerative based treatments has become a big debate. Although the rules and regulations remain unclear, clinicians that are interested should carry-on with the best available guidelines to ensure safety and compliance during delivery in clinical practice to avoid regulatory infraction. Many have made significant investment of time, resources, and facilities in recent years to provide new regenerative treatment options and advance medical care for patients. Instead of reinventing the wheel, it would be more efficient to adopt currently accepted standards and nomenclature borrowed from transplantation science, and cord blood storage industries. The purposes of this article are to provide some historical background to the field of regenerative medicine as it applies to cartilage, and how this field has developed. This will be followed by a separate discussion on regulatory oversight and input and how it has influenced access to care. Furthermore, we discuss current clinical techniques and progress, and ways to deliver these treatments to patients safely, effectively, and in a cost sensitive manner, concluding with an overview of some of the promising regenerative techniques specific to cartilage.

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High Tibial Osteotomy in Combination With Chondrogenesis After Stem Cell Therapy: A Histologic Report of 8 Cases

Cited by 52 publications

References 58 publications

Avoidance of total knee arthroplasty in early osteoarthritis of the knee with intra-articular implantation of autologous activated peripheral blood stem cells versus hyaluronic acid: A randomized controlled trial with differential effects of growth factor addition

Avoidance of total knee arthroplasty in early osteoarthritis of the knee with intra-articular implantation of autologous activated peripheral blood stem cells versus hyaluronic acid: A randomized controlled trial with differential effects of growth factor addition

The Current Perspectives of Stem Cell Therapy in Orthopedic Surgery

Concepts in regenerative medicine: Past, present, and future in articular cartilage treatment

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