“…In their review, less favorable results in patients with Down syndrome were reported by Studer et al [5], Pozzi et al [6], and Morris et al [7], while Rizzoli et al [8] reported that Down syndrome was not an independent risk factor for operative mortality, and that patients with Down syndrome underwent fewer re-operations. Although Reller and Morris [10] reported higher perioperative mortality in complete AVSD with Down syndrome compared with that of without Down syndrome in 1998, many recent papers using multivariate analysis failed to indicate a presence of Down syndrome as a predictor for operative death [11,13,17,[20][21][22]24]. Tweddel et al [13] concluded that routine repair of complete AVSD during infancy in recent era resulted better clinical outcomes.…”